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. 1986 Mar;29(3):515–518. doi: 10.1128/aac.29.3.515

Plasmid-mediated high-level resistance to erythromycin in Escherichia coli.

A Andremont, G Gerbaud, P Courvalin
PMCID: PMC180425  PMID: 3521489

Abstract

Escherichia coli BM2195 was found to be resistant to high levels of erythromycin. This new resistance phenotype was due to the constitutive synthesis of an erythromycin esterase which inactivates the antibiotic. The gene conferring resistance to erythromycin in this strain is carried on a 61-kilobase self-transferable plasmid, pIP1100, belonging to incompatibility group X.

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Selected References

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  1. Andremont A., Raibaud P., Tancrède C. Effect of erythromycin on microbial antagonisms: a study in gnotobiotic mice associated with a human fecal flora. J Infect Dis. 1983 Sep;148(3):579–587. doi: 10.1093/infdis/148.3.579. [DOI] [PubMed] [Google Scholar]
  2. Andremont A., Tancrede C. Reduction of the aerobic Gram negative bacterial flora of the gastro-intestinal tract and prevention of traveller's diarrhea using oral erythromycin. Ann Microbiol (Paris) 1981 Nov-Dec;132 B(3):419–427. [PubMed] [Google Scholar]
  3. Bachmann B. J. Linkage map of Escherichia coli K-12, edition 7. Microbiol Rev. 1983 Jun;47(2):180–230. doi: 10.1128/mr.47.2.180-230.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Barthélémy P., Autissier D., Gerbaud G., Courvalin P. Enzymic hydrolysis of erythromycin by a strain of Escherichia coli. A new mechanism of resistance. J Antibiot (Tokyo) 1984 Dec;37(12):1692–1696. doi: 10.7164/antibiotics.37.1692. [DOI] [PubMed] [Google Scholar]
  5. Bouanchaud D. H., Scavizzi M. R., Chabbert Y. A. Elimination by ethidium bromide of antibiotic resistance in enterobacteria and staphylococci. J Gen Microbiol. 1968 Dec;54(3):417–425. doi: 10.1099/00221287-54-3-417. [DOI] [PubMed] [Google Scholar]
  6. CHABBERT Y. Antagonisme in vitro entre l'érythromycine et la spiramycine. Ann Inst Pasteur (Paris) 1956 Jun;90(6):787–790. [PubMed] [Google Scholar]
  7. CHABBERT Y., BOULINGRE H. Modifications pratiques concernant le dosage des antibiotiques en clinique. Rev Fr Etud Clin Biol. 1957 Jun;2(6):636–640. [PubMed] [Google Scholar]
  8. Chabbert Y. A., Scavizzi M. R., Witchitz J. L., Gerbaud G. R., Bouanchaud D. H. Incompatibility groups and the classification of fi - resistance factors. J Bacteriol. 1972 Nov;112(2):666–675. doi: 10.1128/jb.112.2.666-675.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Courvalin P., Ounissi H., Arthur M. Multiplicity of macrolide-lincosamide-streptogramin antibiotic resistance determinants. J Antimicrob Chemother. 1985 Jul;16 (Suppl A):91–100. doi: 10.1093/jac/16.suppl_a.91. [DOI] [PubMed] [Google Scholar]
  10. Datta N., Hedges R. W., Becker D., Davies J. Plasmid-determined fusidic acid resistance in the Enterobacteriaceae. J Gen Microbiol. 1974 Jul;83(0):191–196. doi: 10.1099/00221287-83-1-191. [DOI] [PubMed] [Google Scholar]
  11. Davies J., Smith D. I. Plasmid-determined resistance to antimicrobial agents. Annu Rev Microbiol. 1978;32:469–518. doi: 10.1146/annurev.mi.32.100178.002345. [DOI] [PubMed] [Google Scholar]
  12. Dutta G. N., Devriese L. A. Macrolide-lincosamide-streptogramin resistance patterns in Clostridium perfringens from animals. Antimicrob Agents Chemother. 1981 Feb;19(2):274–278. doi: 10.1128/aac.19.2.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Flickinger M. C., Perlman D. Microbial degradation of erythromycins A and B. J Antibiot (Tokyo) 1975 Apr;28(4):307–311. doi: 10.7164/antibiotics.28.307. [DOI] [PubMed] [Google Scholar]
  14. Goldstein F. W., Boisivon A., Leclerc P., Acar J. F. Sensibilité d'Hemophilus sp. aux antibiotiques. transfert de résistance à Escherichia coli. Pathol Biol (Paris) 1977 May;25(5):323–332. [PubMed] [Google Scholar]
  15. Haas M. J., Dowding J. E. Aminoglycoside-modifying enzymes. Methods Enzymol. 1975;43:611–628. doi: 10.1016/0076-6879(75)43124-x. [DOI] [PubMed] [Google Scholar]
  16. Labigne-Roussel A., Gerbaud G., Courvalin P. Translocation of sequences encoding antibiotic resistance from the chromosome to a receptor plasmid in Salmonella ordonez. Mol Gen Genet. 1981;182(3):390–408. doi: 10.1007/BF00293927. [DOI] [PubMed] [Google Scholar]
  17. Labigne-Roussel A., Witchitz J., Courvalin P. Modular evolution of disseminated Inc 7-M plasmids encoding gentamicin resistance. Plasmid. 1982 Nov;8(3):215–231. doi: 10.1016/0147-619x(82)90060-9. [DOI] [PubMed] [Google Scholar]
  18. Mathew A., Harris A. M., Marshall M. J., Ross G. W. The use of analytical isoelectric focusing for detection and identification of beta-lactamases. J Gen Microbiol. 1975 May;88(1):169–178. doi: 10.1099/00221287-88-1-169. [DOI] [PubMed] [Google Scholar]
  19. Novick R. P., Clowes R. C., Cohen S. N., Curtiss R., 3rd, Datta N., Falkow S. Uniform nomenclature for bacterial plasmids: a proposal. Bacteriol Rev. 1976 Mar;40(1):168–189. doi: 10.1128/br.40.1.168-189.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Shinnick T. M., Lund E., Smithies O., Blattner F. R. Hybridization of labeled RNA to DNA in agarose gels. Nucleic Acids Res. 1975 Oct;2(10):1911–1929. doi: 10.1093/nar/2.10.1911. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. TAUBENECK U. Susceptibility of Proteus mirabilis and its stable L-forms to erythromycin and other macrolides. Nature. 1962 Oct 13;196:195–196. doi: 10.1038/196195b0. [DOI] [PubMed] [Google Scholar]
  22. Weisblum B. Inducible erythromycin resistance in bacteria. Br Med Bull. 1984 Jan;40(1):47–53. doi: 10.1093/oxfordjournals.bmb.a071947. [DOI] [PubMed] [Google Scholar]
  23. Wittmann H. G., Stöffler G., Apirion D., Rosen L., Tanaka K., Tamaki M., Takata R., Dekio S., Otaka E. Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins. Mol Gen Genet. 1973 Dec 20;127(2):175–189. doi: 10.1007/BF00333665. [DOI] [PubMed] [Google Scholar]

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