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. 1986 Aug;30(2):245–247. doi: 10.1128/aac.30.2.245

Plasmid penicillin resistance in Vibrio cholerae: identification of new beta-lactamase SAR-1.

A J Reid, S G Amyes
PMCID: PMC180527  PMID: 3490216

Abstract

Two strains of Vibrio cholerae biotype El Tor, isolated in Tanzania, possessed a single IncC resistance plasmid of 113 kilobases. Both plasmids encoded the production of a novel beta-lactamase, SAR-1, which was 33,700 daltons in size and was able to hydrolyze carbenicillin as well as penicillin G. The SAR-1 beta-lactamase was quite distinct from all other plasmid beta-lactamases by virtue of its unusually low isoelectric point and a combination of its size, substrate profile, and inhibition properties. This enzyme is only the second beta-lactamase identified in V. cholerae species and the first to be reported in V. cholerae strains isolated in Southern Africa.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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