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. 1981 Feb;19(2):213–217. doi: 10.1128/aac.19.2.213

Inhibition of vaccinia virus maturation by zinc chloride.

E Katz, E Margalith
PMCID: PMC181396  PMID: 7347557

Abstract

Zinc chloride (0.1 mM) inhibited by 96.4% the growth of vaccinia virus in HeLa cells. Approximately 50% inhibition in formation of particles that sedimented in sucrose gradients similarly to vaccinia virions occurred in the presence of zinc ions. Whereas the synthesis of the viral deoxyribonucleic acid was not affected by zinc chloride, a decrease in the overall synthesis of viral polypeptides and inhibition of the cleavage of precursors to the core polypeptides were observed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bracha M., Schlesinger M. J. Inhibition of Sindbis virus replication by zinc ions. Virology. 1976 Jul 1;72(1):272–277. doi: 10.1016/0042-6822(76)90330-5. [DOI] [PubMed] [Google Scholar]
  2. Fridlender B., Chejanovsky N., Becker Y. Selective inhibition of herpes simplex virus type 1 DNA polymerase by zinc ions. Virology. 1978 Feb;84(2):551–554. doi: 10.1016/0042-6822(78)90274-x. [DOI] [PubMed] [Google Scholar]
  3. Gupta P., Rapp F. Effect of zinc ions on synthesis of herpes simplex virus type 2-induced polypeptides. Proc Soc Exp Biol Med. 1976 Jul;152(3):455–458. doi: 10.3181/00379727-152-39417. [DOI] [PubMed] [Google Scholar]
  4. Heller E., Argaman M., Levy H., Goldblum N. Selective inhibition of vaccinia virus by the antibiotic rifampicin. Nature. 1969 Apr 19;222(5190):273–274. doi: 10.1038/222273a0. [DOI] [PubMed] [Google Scholar]
  5. JOKLIK W. K., BECKER Y. THE REPLICATION AND COATING OF VACCINIA DNA. J Mol Biol. 1964 Dec;10:452–474. doi: 10.1016/s0022-2836(64)80066-8. [DOI] [PubMed] [Google Scholar]
  6. Katz E., Margalith E., Winer B., Goldblum N. Synthesis of vaccinia virus polypeptides in the presence of isatin-beta-thiosemicarbazone. Antimicrob Agents Chemother. 1973 Jul;4(1):44–48. doi: 10.1128/aac.4.1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Katz E., Moss B. Formation of a vaccinia virus structural polypeptide from a higher molecular weight precursor: inhibition by rifampicin. Proc Natl Acad Sci U S A. 1970 Jul;66(3):677–684. doi: 10.1073/pnas.66.3.677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Katz E., Moss B. Vaccinia virus structural polypeptide derived from a high-molecular-weight precursor: formation and integration into virus particles. J Virol. 1970 Dec;6(6):717–726. doi: 10.1128/jvi.6.6.717-726.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Katz E., Winer B., Margalith E., Goldblum N. Isolation and characterization of an IBT-dependent mutant of vaccinia virus. J Gen Virol. 1973 Apr;19(1):161–164. doi: 10.1099/0022-1317-19-1-161. [DOI] [PubMed] [Google Scholar]
  10. Korant B. D., Butterworth B. E. Inhibition by zinc of rhinovirus protein cleavage: interaction of zinc with capsid polypeptides. J Virol. 1976 Apr;18(1):298–306. doi: 10.1128/jvi.18.1.298-306.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Korant B. D., Kauer J. C., Butterworth B. E. Zinc ions inhibit replication of rhinoviruses. Nature. 1974 Apr 12;248(449):588–590. doi: 10.1038/248588a0. [DOI] [PubMed] [Google Scholar]
  12. Moss B., Rosenblum E. N., Katz E., Grimley P. M. Rifampicin: a specific inhibitor of vaccinia virus assembly. Nature. 1969 Dec 27;224(5226):1280–1284. doi: 10.1038/2241280a0. [DOI] [PubMed] [Google Scholar]
  13. Moss B., Rosenblum E. N. Letter: Protein cleavage and poxvirus morphogenesis: tryptic peptide analysis of core precursors accumulated by blocking assembly with rifampicin. J Mol Biol. 1973 Dec 5;81(2):267–269. doi: 10.1016/0022-2836(73)90195-2. [DOI] [PubMed] [Google Scholar]
  14. Moss B., Salzman N. P. Sequential protein synthesis following vaccinia virus infection. J Virol. 1968 Oct;2(10):1016–1027. doi: 10.1128/jvi.2.10.1016-1027.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SALZMAN N. P. The rate of formation of vaccinia deoxyribonucleic acid and vaccinia virus. Virology. 1960 Jan;10:150–152. doi: 10.1016/0042-6822(60)90015-5. [DOI] [PubMed] [Google Scholar]
  16. Shlomai J., Asher Y., Gordon Y. J., Olshevsky U., Becker Y. Effect of zinc ions on the synthesis of herpes simplex virus DNA in infected BSC-1 cells. Virology. 1975 Jul;66(1):330–335. doi: 10.1016/0042-6822(75)90204-4. [DOI] [PubMed] [Google Scholar]
  17. Subak-Sharpe J. H., Timbury M. C., Williams J. F. Rifampicin inhibits the growth of some mammalian viruses. Nature. 1969 Apr 26;222(5191):341–345. doi: 10.1038/222341a0. [DOI] [PubMed] [Google Scholar]
  18. Vogt V. M., Eisenman R., Diggelmann H. Generation of avian myeloblastosis virus structural proteins by proteolytic cleavage of a precursor polypeptide. J Mol Biol. 1975 Aug 15;96(3):471–493. doi: 10.1016/0022-2836(75)90174-6. [DOI] [PubMed] [Google Scholar]
  19. Zaslavsky V. Inhibition of vaccinia virus growth by zinc ions: effects on early RNA and thymidine kinase synthesis. J Virol. 1979 Jan;29(1):405–408. doi: 10.1128/jvi.29.1.405-408.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]

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