Skip to main content
PMC home page
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1978 Mar 18;118(6):669–672.

Alpha1-antitrypsin phenotypes and lung function in a moderately polluted northern Ontario community.

D N Ostrow, J Manfreda, T Dorman, R M Cherniack
PMCID: PMC1818022  PMID: 306869

Abstract

To determine whether persons with intermediate value alpha1-antitrypsin phenotypes living in a polluted environment manifest significant abnormalities in lung function, a study was undertaken of an age-, sex- and smoking-stratified sample of 391 persons from the town of Fort Frances, Ont., which has elevated values of total dustfall, suspended particulates and hydrogen sulfide. Indices of pulmonary function were derived from the maximum expiratory flow and the single breath expiratory flow and the single breath expiratory nitrogen washout curves. The percentage frequency of the M, MS and MZ pheontypes was 91.7, 7.3 and 0.8, respectively. There was no significant difference between the M and MS groups as indicated by the nitrogen washout curve and maximum expiratory flow curve. There was no significant difference between the three MZ subjects and the M group. In both M and MS groups smokers displayed evidence of airflow obstruction when compared with nonsmokers. It would appear that, when compared with M subjects, persons with the MS phenotype living in a moderately polluted area show no changes in indicators of pulmonary function, including tests of early airway disease, that cannot be attributed to their smoking habit.

Full text

PDF
669

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buist A. S., Ross B. B. Predicted values for closing volumes using a modified single breath nitrogen test. Am Rev Respir Dis. 1973 May;107(5):744–752. doi: 10.1164/arrd.1973.107.5.744. [DOI] [PubMed] [Google Scholar]
  2. Cole R. B., Nevin N. C., Blundell G., Merrett J. D., McDonald J. R., Johnston W. P. Relation of alpha-1-antitrypsin phenotype to the performance of pulmonary function tests and to the prevalence of respiratory illness in a working population. Thorax. 1976 Apr;31(2):149–157. doi: 10.1136/thx.31.2.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cooper D. M., Hoeppner V., Cox D., Zamel N., Bryan A. C., Levison H. Lung function in alpha1-antitrypsin heterozygotes (Pi type MZ). Am Rev Respir Dis. 1974 Dec;110(6):708–715. doi: 10.1164/arrd.1974.110.6P1.708. [DOI] [PubMed] [Google Scholar]
  4. Cox D. W., Hoeppner V. H., Levison H. Protease inhibitors in patients with chronic obstructive pulmonary disease: the alpha-antitrypsin heterozygote controversy. Am Rev Respir Dis. 1976 May;113(5):601–606. doi: 10.1164/arrd.1976.113.5.601. [DOI] [PubMed] [Google Scholar]
  5. Craven N., Sidwall G., West P., McCarthy D. S., Cherniack R. M. Computer analysis of the single-breath nitrogen washout curve. Am Rev Respir Dis. 1976 Apr;113(4):445–449. doi: 10.1164/arrd.1976.113.4.445. [DOI] [PubMed] [Google Scholar]
  6. Fagerhol M. K., Johnson A. M., Talamo R. C. Letter: First International Alpha-Antitrypsin Pi System Workshop. Am Rev Respir Dis. 1975 Jul;112(1):148–148. doi: 10.1164/arrd.1975.112.1.148b. [DOI] [PubMed] [Google Scholar]
  7. Fagerhol M. K. Serum Pi types in Norwegians. Acta Pathol Microbiol Scand. 1967;70(3):421–428. doi: 10.1111/j.1699-0463.1967.tb01310.x. [DOI] [PubMed] [Google Scholar]
  8. Morse J. O., Lebowitz M. D., Knudson R. J., Burrows B. A community study of the relation of alpha1-antitrypsin levels to obstructive lung diseases. N Engl J Med. 1975 Feb 6;292(6):278–281. doi: 10.1056/NEJM197502062920602. [DOI] [PubMed] [Google Scholar]
  9. Ostrow D. N., Cherniack R. M. The mechanical properties of the lungs in intermediate deficiency of 1 -antitrypsin. Am Rev Respir Dis. 1972 Sep;106(3):377–383. doi: 10.1164/arrd.1972.106.3.377. [DOI] [PubMed] [Google Scholar]
  10. Szczeklik A., Stankowska K., Frydecka I. Cardiopulmonary function in 1 -antitrypsin heterozygotes exposed to severe air pollution. Am Rev Respir Dis. 1973 Feb;107(2):289–291. doi: 10.1164/arrd.1973.107.2.289. [DOI] [PubMed] [Google Scholar]
  11. Webb D. R., Hyde R. W., Schwartz R. H., Hall W. J., Condemi J. J., Townes P. L. Serum alpha 1-antitrypsin variants. Prevalence and clinical spirometry. Am Rev Respir Dis. 1973 Oct;108(4):918–925. doi: 10.1164/arrd.1973.108.4.918. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES