Abstract
Topical treatment of herpes genitalis in female guinea pigs with 2-deoxy-D-glucose in either agarose gels or miconazole nitrate ointments failed to prevent the development of genital lesions or to reduce the mean titers of recoverable virus in vaginal swabs from infected animals. In contrast, phosphonoacetic acid was therapeutically effective.
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- Blough H. A., Giuntoli R. L. Successful treatment of human genital herpes infections with 2-deoxy-D-glucose. JAMA. 1979 Jun 29;241(26):2798–2801. [PubMed] [Google Scholar]
- Blough H. A., Ray E. K. Glucose analogues in the chemotherapy of herpesvirus infections. Pharmacol Ther. 1980;10(3):669–681. doi: 10.1016/0163-7258(80)90033-9. [DOI] [PubMed] [Google Scholar]
- Corey L., Holmes K. K. The use of 2-deoxy-D-glucose for genital herpes. JAMA. 1980 Jan 4;243(1):29–30. [PubMed] [Google Scholar]
- Courtney R. J. Herpes simplex virus protein synthesis in the presence of 2-deoxy-D-glucose. Virology. 1976 Aug;73(1):286–294. doi: 10.1016/0042-6822(76)90081-7. [DOI] [PubMed] [Google Scholar]
- Courtney R. J., Steiner S. M., Benyesh-Melnick M. Effects of 2-deoxy-D-glucose on herpes simplex virus replication. Virology. 1973 Apr;52(2):447–455. doi: 10.1016/0042-6822(73)90340-1. [DOI] [PubMed] [Google Scholar]
- Gallaher W. R., Levitan D. B., Blough H. A. Effect of 2-deoxy-D-glucose on cell fusion induced by Newcastle disease and herpes simplex viruses. Virology. 1973 Sep;55(1):193–201. doi: 10.1016/s0042-6822(73)81021-9. [DOI] [PubMed] [Google Scholar]
- Gauri K. K. Anti-herpesvirus polychemotherapy. Adv Ophthalmol. 1979;38:151–163. [PubMed] [Google Scholar]
- Kern E. R., Glasgow L. A., Overall J. C., Jr, Reno J. M., Boezi J. A. Treatment of experimental herpesvirus infections with phosphonoformate and some comparisons with phosphonoacetate. Antimicrob Agents Chemother. 1978 Dec;14(6):817–823. doi: 10.1128/aac.14.6.817. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Knowles R. W., Person S. Effects of 2-deoxyglucose, glucosamine, and mannose on cell fusion and the glycoproteins of herpes simplex virus. J Virol. 1976 May;18(2):644–651. doi: 10.1128/jvi.18.2.644-651.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kousoulas K. G., Person S., Holland T. C. Timing of some of the molecular events required for cell fusion induced by herpes simplex virus type 1. J Virol. 1978 Sep;27(3):505–512. doi: 10.1128/jvi.27.3.505-512.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ludwig H., Becht H., Rott R. Inhibition of herpes virus-induced cell fusion by concanavalin A, antisera, and 2-deoxy-D-glucose. J Virol. 1974 Aug;14(2):307–314. doi: 10.1128/jvi.14.2.307-314.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ray E. K., Blough H. A. The effect of herpesvirus infection and 2-deoxy-D-glucose on glycosphingolipids in BHK-21 cells. Virology. 1978 Jul 1;88(1):118–127. doi: 10.1016/0042-6822(78)90115-0. [DOI] [PubMed] [Google Scholar]
- Ray E. K., Levitan D. B., Halpern B. L., Blough H. A. A new approach to viral chemotherapy. Inhibitors of glycoprotein synthesis. Lancet. 1974 Sep 21;2(7882):680–683. doi: 10.1016/s0140-6736(74)93261-9. [DOI] [PubMed] [Google Scholar]
- Shannon W. M., Schabel F. M., Jr Antiviral agents as adjuncts in cancer chemotherapy. Pharmacol Ther. 1980;11(2):263–390. doi: 10.1016/0163-7258(80)90034-0. [DOI] [PubMed] [Google Scholar]