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. 1993 Nov;59(11):3661–3665. doi: 10.1128/aem.59.11.3661-3665.1993

Dose response of Cryptosporidium parvum in outbred neonatal CD-1 mice.

G R Finch 1, C W Daniels 1, E K Black 1, F W Schaefer 3rd 1, M Belosevic 1
PMCID: PMC182513  PMID: 8285673

Abstract

Cryptosporidium parvum infectivity in a neonatal CD-1 mouse model was used to determine the dose needed to infect 50% of the population. The 50% infective dose was estimated to be 79 oocysts. It was observed that a mean oral inoculum of 23 oocysts produced infection in 2 of 25 neonatal mice 7 days postinoculation. All animals became infected when the mean oral dose exceeded 310 oocysts per animal. The dose response of C. parvum was modeled with a logit dose-response model suitable for use in water disinfection studies.

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Selected References

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