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. 1988 Oct 22;297(6655):999–1000. doi: 10.1136/bmj.297.6655.999

Flumazenil: a benzodiazepine antagonist.

J G Whitwam 1
PMCID: PMC1834756  PMID: 2903780

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alon E., Baitella L., Hossli G. Double-blind study of the reversal of midazolam-supplemented general anaesthesia with Ro 15-1788. Br J Anaesth. 1987 Apr;59(4):455–458. doi: 10.1093/bja/59.4.455. [DOI] [PubMed] [Google Scholar]
  2. Ashton H. Benzodiazepine withdrawal: an unfinished story. Br Med J (Clin Res Ed) 1984 Apr 14;288(6424):1135–1140. doi: 10.1136/bmj.288.6424.1135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chiolero R. L., Ravussin P., Anderes J. P., Ledermann P., de Tribolet N. The effects of midazolam reversal by RO 15-1788 on cerebral perfusion pressure in patients with severe head injury. Intensive Care Med. 1988;14(3):196–200. doi: 10.1007/BF00717986. [DOI] [PubMed] [Google Scholar]
  4. Cumin R., Bonetti E. P., Scherschlicht R., Haefely W. E. Use of the specific benzodiazepine antagonist, Ro 15-1788, in studies of physiological dependence on benzodiazepines. Experientia. 1982 Jul 15;38(7):833–834. doi: 10.1007/BF01972300. [DOI] [PubMed] [Google Scholar]
  5. Darragh A., Lambe R., Kenny M., Brick I. Tolerance of healthy volunteers to intravenous administration of the benzodiazepine antagonist Ro 15-1788. Eur J Clin Pharmacol. 1983;24(4):569–570. doi: 10.1007/BF00609905. [DOI] [PubMed] [Google Scholar]
  6. Desenclos J. C. Relief food and vitamin C deficiency. Lancet. 1987 Aug 22;2(8556):462–463. doi: 10.1016/s0140-6736(87)91006-3. [DOI] [PubMed] [Google Scholar]
  7. File S. E., Baldwin H. A. Flumazenil: a possible treatment for benzodiazepine withdrawal anxiety. Lancet. 1987 Jul 11;2(8550):106–107. doi: 10.1016/s0140-6736(87)92779-6. [DOI] [PubMed] [Google Scholar]
  8. Flumazenil and benzodiazepine withdrawal. Lancet. 1987 Aug 22;2(8556):463–463. [PubMed] [Google Scholar]
  9. Kirkegaard L., Knudsen L., Jensen S., Kruse A. Benzodiazepine antagonist Ro 15-1788. Antagonism of diazepam sedation in outpatients undergoing gastroscopy. Anaesthesia. 1986 Dec;41(12):1184–1188. doi: 10.1111/j.1365-2044.1986.tb13001.x. [DOI] [PubMed] [Google Scholar]
  10. Kleinberger G., Grimm G., Laggner A., Drume W., Lenz K., Schneeweiss B. Weaning patients from mechanical ventilation by benzodiazepine antagonist Ro15-1788. Lancet. 1985 Aug 3;2(8449):268–269. doi: 10.1016/s0140-6736(85)90309-5. [DOI] [PubMed] [Google Scholar]
  11. Klotz U., Kanto J. Pharmacokinetics and clinical use of flumazenil (Ro 15-1788). Clin Pharmacokinet. 1988 Jan;14(1):1–12. doi: 10.2165/00003088-198814010-00001. [DOI] [PubMed] [Google Scholar]
  12. Klotz U., Ziegler G., Ludwig L., Reimann I. W. Pharmacodynamic interaction between midazolam and a specific benzodiazepine antagonist in humans. J Clin Pharmacol. 1985 Sep;25(6):400–406. doi: 10.1002/j.1552-4604.1985.tb02866.x. [DOI] [PubMed] [Google Scholar]
  13. Klotz U., Ziegler G., Reimann I. W. Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man. Eur J Clin Pharmacol. 1984;27(1):115–117. [PubMed] [Google Scholar]
  14. Lauven P. M., Schwilden H., Stoeckel H., Greenblatt D. J. The effects of a benzodiazepine antagonist Ro 15-1788 in the presence of stable concentrations of midazolam. Anesthesiology. 1985 Jul;63(1):61–64. doi: 10.1097/00000542-198507000-00009. [DOI] [PubMed] [Google Scholar]
  15. Lugaresi E., Medori R., Montagna P., Baruzzi A., Cortelli P., Lugaresi A., Tinuper P., Zucconi M., Gambetti P. Fatal familial insomnia and dysautonomia with selective degeneration of thalamic nuclei. N Engl J Med. 1986 Oct 16;315(16):997–1003. doi: 10.1056/NEJM198610163151605. [DOI] [PubMed] [Google Scholar]
  16. O'Boyle C., Lambe R., Darragh A., Taffe W., Brick I., Kenny M. Ro 15-1788 antagonizes the effects of diazepam in man without affecting its bioavailability. Br J Anaesth. 1983 Apr;55(4):349–356. doi: 10.1093/bja/55.4.349. [DOI] [PubMed] [Google Scholar]
  17. Ricou B., Forster A., Brückner A., Chastonay P., Gemperle M. Clinical evaluation of a specific benzodiazepine antagonist (RO 15-1788). Studies in elderly patients after regional anaesthesia under benzodiazepine sedation. Br J Anaesth. 1986 Sep;58(9):1005–1011. doi: 10.1093/bja/58.9.1005. [DOI] [PubMed] [Google Scholar]
  18. Sage D. J., Close A., Boas R. A. Reversal of midazolam sedation with anexate. Br J Anaesth. 1987 Apr;59(4):459–464. doi: 10.1093/bja/59.4.459. [DOI] [PubMed] [Google Scholar]
  19. Samson Y., Hantraye P., Baron J. C., Soussaline F., Comar D., Mazière M. Kinetics and displacement of [11C]RO 15-1788, a benzodiazepine antagonist, studied in human brain in vivo by positron tomography. Eur J Pharmacol. 1985 Apr 2;110(2):247–251. doi: 10.1016/0014-2999(85)90218-3. [DOI] [PubMed] [Google Scholar]
  20. Scollo-Lavizzari G. First clinical investigation of the benzodiazepine antagonist Ro 15-1788 in comatose patients. Eur Neurol. 1983;22(1):7–11. doi: 10.1159/000115529. [DOI] [PubMed] [Google Scholar]
  21. Scollo-Lavizzari G., Matthis H. Benzodiazepine antagonist (RO 15-1788) in ethanol intoxication: a pilot study. Eur Neurol. 1985;24(5):352–354. doi: 10.1159/000115824. [DOI] [PubMed] [Google Scholar]
  22. Shinotoh H., Yamasaki T., Inoue O., Itoh T., Suzuki K., Hashimoto K., Tateno Y., Ikehira H. Visualization of specific binding sites of benzodiazepine in human brain. J Nucl Med. 1986 Oct;27(10):1593–1599. [PubMed] [Google Scholar]

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