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. 1982 Jul;22(1):128–136. doi: 10.1128/aac.22.1.128

Penicillin-resistant and penicillin-tolerant mutants of group A Streptococci.

L Gutmann, A Tomasz
PMCID: PMC183685  PMID: 6181734

Abstract

Penicillin-resistant and penicillin-tolerant mutants have been isolated from group A streptococci mutagenized by ethyl methane sulfonate. The resistant mutants had an elevated minimal growth inhibitory concentration for benzylpenicillin (minimal inhibitory concentration, 0.2 microgram/ml, as compared with the minimal inhibitory concentration of 0.006 microgram/ml in the penicillin-susceptible parent strain); they also had an abnormal cellular morphology and showed altered penicillin-binding proteins. Penicillin-tolerant mutants were killed more slowly than were the parental cells during treatment with penicillin; they had virtually unchanged minimal inhibitory concentration values for penicillin and normal cellular morphology and penicillin-binding proteins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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