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. 1989 Sep 2;299(6699):587–591. doi: 10.1136/bmj.299.6699.587

Early influences on blood pressure: a study of children aged 5-7 years.

P H Whincup 1, D G Cook 1, A G Shaper 1
PMCID: PMC1837466  PMID: 2508814

Abstract

OBJECTIVE--To examine factors that influence blood pressure in children. DESIGN--Cross sectional study of children aged 5.0-7.0 years who had blood pressure measurements and for whom parental questionnaires were completed. SETTING--School based survey. SUBJECTS--3591 Children aged 5.0-7.5 years selected by stratified random sampling of primary schools in nine British towns (response rate 72%); 3591 were examined and their parental questionnaires were completed. Data were complete for birth rank in 3559, maternal age in 3542, maternal history of hypertension in 3524, and paternal history in 2633. RESULTS--Birth weight was inversely related to mean systolic blood pressure but only when standardised for current weight (weight standardised regression coefficient -1.83 mm Hg/kg (95% confidence interval -1.31 to -2.35). Mean diastolic pressure was similarly related to birth weight. Maternal age, birth rank, and a parental history of hypertension were all related to blood pressure. After standardisation for current weight a 10 year increase in maternal age was associated with a 1.0 mm Hg (0.4 to 1.6) rise in systolic pressure; first born children had systolic blood pressure on average 2.53 mm Hg (0.81 to 4.25) higher than those whose birth rank was greater than or equal to 4; and a maternal history of hypertension was associated with a systolic pressure on average 0.96 mm Hg (0.41 to 1.51) higher than in those with no such history. The effects described were largely independent of one another and of age and social class. The relation for birth rank was, however, closely related to that for family size. CONCLUSIONS--Influences acting in early life may be important determinants of blood pressure in the first decade. The relation between birth weight and blood pressure may reflect the rate of weight gain in infancy. The reasons for the relation with birth rank and maternal age are unknown; if confirmed they imply that delayed motherhood and smaller family size may be associated with higher blood pressure in offspring.

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Selected References

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  1. Barker D. J., Osmond C., Golding J., Kuh D., Wadsworth M. E. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ. 1989 Mar 4;298(6673):564–567. doi: 10.1136/bmj.298.6673.564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bucci G., Scalamandrè A., Savignoni P. G., Mendicini M., Picece-Bucci S. The systemic systolic blood pressure of newborns with low weight. A multiple regression analysis. Acta Paediatr Scand Suppl. 1972;229:1–26. [PubMed] [Google Scholar]
  3. Cruise M. O. A longitudinal study of the growth of low birth weight infants. I. Velocity and distance growth, birth to 3 years. Pediatrics. 1973 Apr;51(4):620–628. [PubMed] [Google Scholar]
  4. Eaton-Evans J., Dugdale A. E. Recall by mothers of the birth weights and feeding of their children. Hum Nutr Appl Nutr. 1986 Jun;40(3):171–175. [PubMed] [Google Scholar]
  5. Gennser G., Rymark P., Isberg P. E. Low birth weight and risk of high blood pressure in adulthood. Br Med J (Clin Res Ed) 1988 May 28;296(6635):1498–1500. doi: 10.1136/bmj.296.6635.1498. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HOLLAND W. W., YOUNG I. M. Neonatal blood pressure in relation to maturity, mode of delivery, and condition at birth. Br Med J. 1956 Dec 8;2(5005):1331–1333. doi: 10.1136/bmj.2.5005.1331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hofman A., Hazebroek A., Valkenburg H. A. A randomized trial of sodium intake and blood pressure in newborn infants. JAMA. 1983 Jul 15;250(3):370–373. [PubMed] [Google Scholar]
  8. Kitterman J. A., Phibbs R. H., Tooley W. H. Aortic blood pressure in normal newborn infants during the first 12 hours of life. Pediatrics. 1969 Dec;44(6):959–968. [PubMed] [Google Scholar]
  9. Lee Y. H., Rosner B., Gould J. B., Lowe E. W., Kass E. H. Familial aggregation of blood pressures of newborn infants and their mother. Pediatrics. 1976 Nov;58(5):722–729. [PubMed] [Google Scholar]
  10. Levine R. S., Hennekens C. H., Klein B., Gourley J., Briese F. W., Hokanson J., Gelband H., Jesse M. J. Tracking correlations of blood pressure levels in infancy. Pediatrics. 1978 Jan;61(1):121–125. [PubMed] [Google Scholar]
  11. Lucas A., Morley R., Hudson G. J., Bamford M. F., Boon A., Crowle P., Dossetor J. F., Pearse R. Early sodium intake and later blood pressure in preterm infants. Arch Dis Child. 1988 Jun;63(6):656–657. doi: 10.1136/adc.63.6.656. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Marmot M. G., Page C. M., Atkins E., Douglas J. W. Effect of breast-feeding on plasma cholesterol and weight in young adults. J Epidemiol Community Health. 1980 Sep;34(3):164–167. doi: 10.1136/jech.34.3.164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ounsted M. K., Cockburn J. M., Moar V. A., Redman C. W. Factors associated with the blood pressures of children born to women who were hypertensive during pregnancy. Arch Dis Child. 1985 Jul;60(7):631–635. doi: 10.1136/adc.60.7.631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Schachter J., Kuller L. H., Perkins J. M., Radin M. E. Infant blood pressure and heart rate: relation to ethnic group (black or white), nutrition and electrolyte intake. Am J Epidemiol. 1979 Aug;110(2):205–218. doi: 10.1093/oxfordjournals.aje.a112805. [DOI] [PubMed] [Google Scholar]
  15. Shaper A. G., Ashby D., Pocock S. J. Blood pressure and hypertension in middle-aged British men. J Hypertens. 1988 May;6(5):367–374. [PubMed] [Google Scholar]
  16. THOMSON J. Observations on weight gain in infants. Arch Dis Child. 1955 Aug;30(152):322–327. doi: 10.1136/adc.30.152.322. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Versmold H. T., Kitterman J. A., Phibbs R. H., Gregory G. A., Tooley W. H. Aortic blood pressure during the first 12 hours of life in infants with birth weight 610 to 4,220 grams. Pediatrics. 1981 May;67(5):607–613. [PubMed] [Google Scholar]
  18. Wadsworth M. E., Cripps H. A., Midwinter R. E., Colley J. R. Blood pressure in a national birth cohort at the age of 36 related to social and familial factors, smoking, and body mass. Br Med J (Clin Res Ed) 1985 Nov 30;291(6508):1534–1538. doi: 10.1136/bmj.291.6508.1534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Whincup P. H., Cook D. G., Shaper A. G., Macfarlane D. J., Walker M. Blood pressure in British children: associations with adult blood pressure and cardiovascular mortality. Lancet. 1988 Oct 15;2(8616):890–893. doi: 10.1016/s0140-6736(88)92481-6. [DOI] [PubMed] [Google Scholar]
  20. Zinner S. H., Levy P. S., Kass E. H. Familial aggregation of blood pressure in childhood. N Engl J Med. 1971 Feb 25;284(8):401–404. doi: 10.1056/NEJM197102252840801. [DOI] [PubMed] [Google Scholar]
  21. de Swiet M., Fayers P., Shinebourne E. A. Blood pressure survey in a population of newborn infants. Br Med J. 1976 Jul 3;2(6026):9–11. doi: 10.1136/bmj.2.6026.9. [DOI] [PMC free article] [PubMed] [Google Scholar]

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