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. 1982 Sep;22(3):515–517. doi: 10.1128/aac.22.3.515

Gonococcal opacity variants: susceptibility to antimicrobial agents.

I E Salit, M Bond
PMCID: PMC183775  PMID: 6814357

Abstract

We tested the susceptibility of 34 pairs of isogenic opaque and transparent colony variants of gonococci to nine antimicrobial agents. Only 20% of the opaque and transparent minimal inhibitory concentrations were discordant, and the mean minimal inhibitory concentrations were not significantly different. Selection of opacity variants is, therefore, not necessary for routine susceptibility testing.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bumgarner L. R., Finkelstein R. A. Pathogenesis and immunology of experimental gonococcal infection: virulence of colony types of Neisseria gonorrhoeae for chicken embryos. Infect Immun. 1973 Dec;8(6):919–924. doi: 10.1128/iai.8.6.919-924.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Finland M., Garner C., Wilcox C., Sabath L. D. Susceptibility of Neisseria gonorrhoeae to 66 antibacterial agents in vitro. J Am Vener Dis Assoc. 1976 Mar;2(3):33–40. [PubMed] [Google Scholar]
  3. Hall W. H., Schierl E. A., Maccani J. E. Comparative susceptibility of penicillinase-positive and -negative Neisseria gonorrhoeae to 30 antibiotics. Antimicrob Agents Chemother. 1979 Apr;15(4):562–567. doi: 10.1128/aac.15.4.562. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. James J. F., Swanson J. Studies on gonococcus infection. XIII. Occurrence of color/opacity colonial variants in clinical cultures. Infect Immun. 1978 Jan;19(1):332–340. doi: 10.1128/iai.19.1.332-340.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Jephcott A. E., Reyn A. Neisseria gonorrhoeae. Colony variation I. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;79(5):609–614. doi: 10.1111/j.1699-0463.1971.tb00088.x. [DOI] [PubMed] [Google Scholar]
  6. KELLOGG D. S., Jr, PEACOCK W. L., Jr, DEACON W. E., BROWN L., PIRKLE D. I. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION. J Bacteriol. 1963 Jun;85:1274–1279. doi: 10.1128/jb.85.6.1274-1279.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kellogg D. S., Jr, Cohen I. R., Norins L. C., Schroeter A. L., Reising G. Neisseria gonorrhoeae. II. Colonial variation and pathogenicity during 35 months in vitro. J Bacteriol. 1968 Sep;96(3):596–605. doi: 10.1128/jb.96.3.596-605.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kraus S. J., Brown W. J., Arko R. J. Acquired and natural immunity to gonococcal infection in chimpanzees. J Clin Invest. 1975 Jun;55(6):1349–1356. doi: 10.1172/JCI108054. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lim D. V. Differences in susceptibilities of virulent strains and avirulent strains of Neisseria gonorrhoeae to antimicrobial agents. Antimicrob Agents Chemother. 1978 Jul;14(1):45–50. doi: 10.1128/aac.14.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Meheus A., Piot P., Pattyn S., van Dyck E., van den Berghe D. Activity in vitro of ten antimicrobial agents against Neisseria gonorrhoeae. A study of the correlation between the sensitivities. Br J Vener Dis. 1976 Oct;52(5):329–332. doi: 10.1136/sti.52.5.329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ng W. S., Anton P., Arnold K. Neisseria gonorrhoeae strains isolated in Hong Kong: in vitro susceptibility to 13 antibiotics. Antimicrob Agents Chemother. 1981 Jan;19(1):12–17. doi: 10.1128/aac.19.1.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Robson H. G., Salit I. E. Susceptibility of Neisseria gonorrhoeae to seven antibiotics in vitro. Can Med Assoc J. 1972 Nov 18;107(10):959–962. [PMC free article] [PubMed] [Google Scholar]
  13. Salit I. E., Blake M., Gotschlich E. C. Intra-strain heterogeneity of gonococcal pili is related to opacity colony variance. J Exp Med. 1980 Mar 1;151(3):716–725. doi: 10.1084/jem.151.3.716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Salit I. E., Gotschlich E. C. Gonococcal color and opacity variants: virulence for chicken embryos. Infect Immun. 1978 Nov;22(2):359–364. doi: 10.1128/iai.22.2.359-364.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Salit I. E. The differential susceptibility of gonococcal opacity variants to sex hormones. Can J Microbiol. 1982 Mar;28(3):301–306. doi: 10.1139/m82-044. [DOI] [PubMed] [Google Scholar]
  16. Swanson J. Studies on gonococcus infection. XII. Colony color and opacity varienats of gonococci. Infect Immun. 1978 Jan;19(1):320–331. doi: 10.1128/iai.19.1.320-331.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Swanson J. Studies on gonococcus infection. XIV. Cell wall protein differences among color/opacity colony variants of Neisseria gonorrhoeae. Infect Immun. 1978 Jul;21(1):292–302. doi: 10.1128/iai.21.1.292-302.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]

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