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. 1991 Oct;57(10):2995–2999. doi: 10.1128/aem.57.10.2995-2999.1991

Deletion of pgi alters tryptophan biosynthesis in a genetically engineered strain of Escherichia coli.

D Mascarenhas 1, D J Ashworth 1, C S Chen 1
PMCID: PMC183910  PMID: 1746959

Abstract

Deletion of the structural gene for phosphoglucose isomerase (pgi) of Escherichia coli dramatically alters the path of glucose catabolism by diverting carbon into the hexose monophosphate shunt. The effect of this genetic alteration on the conversion of glucose to tryptophan by strains optimized for the biosynthesis of this amino acid was determined by using 13C-nuclear magnetic resonance spectroscopy in vivo. Pgi- strains converted glucose to tryptophan almost twice as efficiently as did their Pgi+ counterparts.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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