Abstract
The in vitro interactions of four beta-lactam antibiotics and five antineoplastic agents were examined with 100 clinically isolated strains of four species of gram-negative bacilli. Generally, by the checkerboard dilution method, beta-lactam antibiotics, when tested in combination with mitomycin C, bleomycin, or 5-fluorouracil, showed synergistic action, whereas when tested in combination with carboquone, they showed antagonistic action. Almost no combinations of adriamycin showed the interactions. Among beta-lactam antibiotics, piperacillin was more frequently synergistic than cefoperazone, cefazolin, or carbenicillin when tested in combination with each antineoplastic agent against various species.
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Selected References
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- Berenbaum M. C. A method for testing for synergy with any number of agents. J Infect Dis. 1978 Feb;137(2):122–130. doi: 10.1093/infdis/137.2.122. [DOI] [PubMed] [Google Scholar]
- Coles N. W., Gross R. The effect of mitomycin C on the induced synthesis of penicillinase in Staphylococcus aureus. Biochem Biophys Res Commun. 1965 Jul 26;20(3):366–371. doi: 10.1016/0006-291x(65)90374-8. [DOI] [PubMed] [Google Scholar]
- ELION G. B., SINGER S., HITCHINGS G. H. Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites. J Biol Chem. 1954 Jun;208(2):477–488. [PubMed] [Google Scholar]
- Gudas L. J., Pardee A. B. DNA synthesis inhibition and the induction of protein X in Escherichia coli. J Mol Biol. 1976 Mar 15;101(4):459–477. doi: 10.1016/0022-2836(76)90240-0. [DOI] [PubMed] [Google Scholar]
- Jacobs J. Y., Michel J., Sacks T. Bactericidal effect of combinations of antimicrobial drugs and antineoplastic antibiotics against Staphylococcus aureus. Antimicrob Agents Chemother. 1979 Apr;15(4):580–586. doi: 10.1128/aac.15.4.580. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Manten A., Terra J. I. Some observations on antagonism between penicillin and antineoplastic antibiotics. Acta Physiol Pharmacol Neerl. 1967;14(3):250–258. [PubMed] [Google Scholar]
- Michel J., Jacobs J. Y., Sacks T. Bactericidal effect of combinations of antimicrobial drugs and antineoplastic antibiotics against gram-negative bacilli. Antimicrob Agents Chemother. 1979 Dec;16(6):761–766. doi: 10.1128/aac.16.6.761. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moody M. R., Morris M. J., Young V. M., Moyé L. A., 3rd, Schimpff S. C., Wiernik P. H. Effect of two cancer chemotherapeutic agents on the antibacterial activity of three antimicrobial agents. Antimicrob Agents Chemother. 1978 Nov;14(5):737–742. doi: 10.1128/aac.14.5.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wright D. N., Matsen J. M. Bioassay of antibiotics in body fluids from patients receiving cancer chemotherapeutic agents. Antimicrob Agents Chemother. 1980 Mar;17(3):417–422. doi: 10.1128/aac.17.3.417. [DOI] [PMC free article] [PubMed] [Google Scholar]