Abstract
The penetration of ceftriaxone into the fetus at parturition was studied in 17 subjects. Despite its high protein binding, ceftriaxone quickly reached the umbilical cord blood, amniotic fluid, and placenta, achieving substantial concentrations, which then disappeared, with elimination half-lives of approximately 6 h, identical to that of the mother. The elimination half-life of ceftriaxone of 5 to 6 h in these mothers was somewhat shorter than that reported for normal subjects. The concentrations of ceftriaxone achieved in fetal tissues were sufficient for therapeutic effects. The penetration of ceftriaxone into milk was studied 3 days postpartum in 20 other patients. This antimicrobial agent entered breast milk rapidly and disappeared with a half-life of 12 to 17 h. The concentrations achieved were only 3 to 4% of those in maternal serum and were most likely of little clinical relevance.
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Selected References
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- Arthur L. J., Burland W. L. Transfer of cephaloridine from mother to fetus. Arch Dis Child. 1969 Feb;44(233):82–83. doi: 10.1136/adc.44.233.82. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bernard B., Barton L., Abate M., Ballard C. A. Maternal-fetal transfer of cefazolin in the first twenty weeks of pregnancy. J Infect Dis. 1977 Sep;136(3):377–382. doi: 10.1093/infdis/136.3.377. [DOI] [PubMed] [Google Scholar]
- Bernard B., Garcia-Cazares S. J., Ballard C. A., Thrupp L. D., Mathies A. W., Wehrle P. F. Tobramycin: maternal-fetal pharmacology. Antimicrob Agents Chemother. 1977 Apr;11(4):688–694. doi: 10.1128/aac.11.4.688. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bernard B., Thielen P., Garcia-Cázares J., Ballard C. A. Maternal-fetal pharmacology of cefatrizine in the first 20 weeks of pregnancy. Antimicrob Agents Chemother. 1977 Aug;12(2):231–236. doi: 10.1128/aac.12.2.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Craft I., Forster T. C. Materno-fetal cephradine transfer in pregnancy. Antimicrob Agents Chemother. 1978 Dec;14(6):924–926. doi: 10.1128/aac.14.6.924. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kafetzis D. A., Lazarides C. V., Siafas C. A., Georgakopoulos P. A., Papadatos C. J. Transfer of cefotaxime in human milk and from mother to foetus. J Antimicrob Chemother. 1980 Sep;6 (Suppl A):135–141. doi: 10.1093/jac/6.suppl_a.135. [DOI] [PubMed] [Google Scholar]
- MacAulay M. A., Molloy W. B., Charles D. Placental transfer of methicillin. Am J Obstet Gynecol. 1973 Jan 1;115(1):58–65. doi: 10.1016/0002-9378(73)90089-6. [DOI] [PubMed] [Google Scholar]
- Neu H. C. The new beta-lactamase-stable cephalosporins. Ann Intern Med. 1982 Sep;97(3):408–419. doi: 10.7326/0003-4819-97-3-408. [DOI] [PubMed] [Google Scholar]
- Patel I. H., Miller K., Weinfeld R., Spicehandler J. Multiple intravenous dose pharmacokinetics of ceftriaxone in man. Chemotherapy. 1981;27 (Suppl 1):47–56. doi: 10.1159/000238029. [DOI] [PubMed] [Google Scholar]
- Philipson A. Pharmacokinetics of antibiotics in pregnancy and labour. Clin Pharmacokinet. 1979 Jul-Aug;4(4):297–309. doi: 10.2165/00003088-197904040-00003. [DOI] [PubMed] [Google Scholar]
- Sedman A. J., Wagner J. G. CSTRIP, a fortran IV computer program for obtaining initial polyexponential parameter estimates. J Pharm Sci. 1976 Jul;65(7):1006–1010. doi: 10.1002/jps.2600650713. [DOI] [PubMed] [Google Scholar]
- Weinstein A. J., Gibbs R. S., Gallagher M. Placental transfer of clindamycin and gentamicin in term pregnancy. Am J Obstet Gynecol. 1976 Apr 1;124(7):688–691. doi: 10.1016/s0002-9378(16)33336-1. [DOI] [PubMed] [Google Scholar]