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. 1983 Jul;24(1):61–69. doi: 10.1128/aac.24.1.61

Occurrence and expression of imipemide (N-formimidoyl thienamycin) resistance in clinical isolates of coagulase-negative staphylococci.

R M Blumenthal, R Raeder, C D Takemoto, E H Freimer
PMCID: PMC185105  PMID: 6578701

Abstract

More than 500 clinical isolates were screened for resistance to a number of antibiotics, including imipemide (N-formimidoyl thienamycin [MK0787]). Of the 25 coagulase-negative staphylococcal isolates present in the screening sample, almost one-third showed one of two patterns of imipemide resistance. One pattern apparently involves constitutive expression of drug resistance, whereas the other pattern seems to result from an inducible resistance having an apparent induction threshold higher than the minimal inhibitory concentration of imipemide. The mechanism(s) responsible for this imipemide resistance is unclear, but may be distinct from the more common staphylococcal mechanisms of resistance to beta-lactam antibiotics. Only two of the patients from whom imipemide-resistant staphylococci were cultured had actually been treated with the antibiotic.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barany F., Boeke J. D., Tomasz A. Staphylococcal plasmids that replicate and express erythromycin resistance in both Streptococcus pneumoniae and Escherichia coli. Proc Natl Acad Sci U S A. 1982 May;79(9):2991–2995. doi: 10.1073/pnas.79.9.2991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
  3. Benveniste R., Davies J. Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc Natl Acad Sci U S A. 1973 Aug;70(8):2276–2280. doi: 10.1073/pnas.70.8.2276. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cohen M. L., Wong E. S., Falkow S. Common R-plasmids in Staphylococcus aureus and Staphylococcus epidermidis during a nosocomial Staphylococcus aureus outbreak. Antimicrob Agents Chemother. 1982 Feb;21(2):210–215. doi: 10.1128/aac.21.2.210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cohen S., Sweeney H. M. Transduction of Methicillin Resistance in Staphylococcus aureus Dependent on an Unusual Specificity of the Recipient Strain. J Bacteriol. 1970 Dec;104(3):1158–1167. doi: 10.1128/jb.104.3.1158-1167.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Courvalin P., Weisblum B., Davies J. Aminoglycoside-modifying enzyme of an antibiotic-producing bacterium acts as a determinant of antibiotic resistance in Escherichia coli. Proc Natl Acad Sci U S A. 1977 Mar;74(3):999–1003. doi: 10.1073/pnas.74.3.999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Demain A. L. How do antibiotic-producing microorganisms avoid suicide? Ann N Y Acad Sci. 1974 May 10;235(0):601–612. doi: 10.1111/j.1749-6632.1974.tb43294.x. [DOI] [PubMed] [Google Scholar]
  8. EAGLE H. Further observations on the zone phenomenon in the bactericidal action of penicillin. J Bacteriol. 1951 Nov;62(5):663–668. doi: 10.1128/jb.62.5.663-668.1951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ehrlich S. D. Replication and expression of plasmids from Staphylococcus aureus in Bacillus subtilis. Proc Natl Acad Sci U S A. 1977 Apr;74(4):1680–1682. doi: 10.1073/pnas.74.4.1680. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Keys T. F., Hewitt W. L. Endocarditis due to Micrococci and Staphylococcus epidermidis. Arch Intern Med. 1973 Aug;132(2):216–220. [PubMed] [Google Scholar]
  11. Lai C. J., Weisblum B., Fahnestock S. R., Nomura M. Alteration of 23 S ribosomal RNA and erythromycin-induced resistance to lincomycin and spiramycin in Staphylococcus aureus. J Mol Biol. 1973 Feb 15;74(1):67–72. doi: 10.1016/0022-2836(73)90355-0. [DOI] [PubMed] [Google Scholar]
  12. Livingston W. K., Elliott A. M., Cobbs C. G. In vitro activity of N-formimidoyl thienamycin (MK0787) against resistant strains of Pseudomonas aeruginosa, Staphylococcus epidermidis, Serratia marcescens, and Enterococcus spp. Antimicrob Agents Chemother. 1981 Jan;19(1):114–116. doi: 10.1128/aac.19.1.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Meers P. D., Whyte W., Sandys G. Coagulase-negative staphylococci and micrococci in urinary tract infections. J Clin Pathol. 1975 Apr;28(4):270–273. doi: 10.1136/jcp.28.4.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Neu H. C., Labthavikul P. Comparative in vitro activity of N-formimidoyl thienamycin against gram-positive and gram-negative aerobic and anaerobic species and its beta-lactamase stability. Antimicrob Agents Chemother. 1982 Jan;21(1):180–187. doi: 10.1128/aac.21.1.180. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Ogawara H. Antibiotic resistance in pathogenic and producing bacteria, with special reference to beta-lactam antibiotics. Microbiol Rev. 1981 Dec;45(4):591–619. doi: 10.1128/mr.45.4.591-619.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Pead L., Crump J., Maskell R. Staphylococci as urinary pathogens. J Clin Pathol. 1977 May;30(5):427–431. doi: 10.1136/jcp.30.5.427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Polak J., Novick R. P. Closely related plasmids from Staphylococcus aureus and soil bacilli. Plasmid. 1982 Mar;7(2):152–162. doi: 10.1016/0147-619x(82)90074-9. [DOI] [PubMed] [Google Scholar]
  18. Pollock M. R. Origin and function of penicillinase: a problem in biochemical evolution. Br Med J. 1967 Oct 14;4(5571):71–77. doi: 10.1136/bmj.4.5571.71. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rosdahl V. T. Naturally occurring constitutive -lactamase of novel serotype in Staphylococcus aureus. J Gen Microbiol. 1973 Jul;77(1):229–231. doi: 10.1099/00221287-77-1-229. [DOI] [PubMed] [Google Scholar]
  20. Sabath L. D., Wheeler N., Laverdiere M., Blazevic D., Wilkinson B. J. A new type of penicillin resistance of Staphylococcus aureus. Lancet. 1977 Feb 26;1(8009):443–447. doi: 10.1016/s0140-6736(77)91941-9. [DOI] [PubMed] [Google Scholar]
  21. Saino Y., Kobayashi F., Inoue M., Mitsuhashi S. Purification and properties of inducible penicillin beta-lactamase isolated from Pseudomonas maltophilia. Antimicrob Agents Chemother. 1982 Oct;22(4):564–570. doi: 10.1128/aac.22.4.564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Sawada Y., Yaginuma S., Tai M., Iyobe S., Mitsuhashi S. Plasmid-mediated penicillin beta-lactamases in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1976 Jan;9(1):55–60. doi: 10.1128/aac.9.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Spratt B. G. Escherichia coli resistance to beta-lactam antibiotics through a decrease in the affinity of a target for lethality. Nature. 1978 Aug 17;274(5672):713–715. doi: 10.1038/274713a0. [DOI] [PubMed] [Google Scholar]
  24. Stewart G. C., Rosenblum E. D. Transduction of methicillin resistance in Staphylococcus aureus: recipient effectiveness and beta-lactamase production. Antimicrob Agents Chemother. 1980 Sep;18(3):424–432. doi: 10.1128/aac.18.3.424. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Tally F. P., Jacobus N. V., Gorbach S. L. In vitro activity of N-formimidoyl thienamycin (MK0787). Antimicrob Agents Chemother. 1980 Oct;18(4):642–644. doi: 10.1128/aac.18.4.642. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Then R. L., Angehrn P. Trapping of nonhydrolyzable cephalosporins by cephalosporinases in Enterobacter cloacae and Pseudomonas aeruginosa as a possible resistance mechanism. Antimicrob Agents Chemother. 1982 May;21(5):711–717. doi: 10.1128/aac.21.5.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Toda M., Sato K., Nakazawa H., Inoue M., Mitsuhashi S. Effect of N-formimidoyl thienamycin (MK0787) on beta-lactamases and activity against beta-lactamase-producing strains. Antimicrob Agents Chemother. 1980 Nov;18(5):837–838. doi: 10.1128/aac.18.5.837. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Tutlane V. A., McCloskey R. V., Trent J. A. In vitro comparison of N-formimidoyl thienamycin, piperacillin, cefotaxime, and cefoperazone. Antimicrob Agents Chemother. 1981 Jul;20(1):140–143. doi: 10.1128/aac.20.1.140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Vining L. C. Antibiotic tolerance in producer organisms. Adv Appl Microbiol. 1979;25:147–168. doi: 10.1016/s0065-2164(08)70149-7. [DOI] [PubMed] [Google Scholar]
  30. Wallmark G., Arremark I., Telander B. Staphylococcus saprophyticus: a frequent cause of acute urinary tract infection among female outpatients. J Infect Dis. 1978 Dec;138(6):791–797. doi: 10.1093/infdis/138.6.791. [DOI] [PubMed] [Google Scholar]

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