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. 1987 Sep;92(1):5–11. doi: 10.1111/j.1476-5381.1987.tb11288.x

Inhibition of the rate of GABA synthesis in regions of rat brain following a convulsion.

A R Green 1, A Metz 1, M C Minchin 1, N D Vincent 1
PMCID: PMC1853628  PMID: 3664092

Abstract

1 The rate of synthesis of gamma-aminobutyric acid (GABA) in the cortex, hippocampus and striatum of rat brain was assessed by measuring the linear rate of accumulation of GABA following injection of amino-oxyacetic acid (AOAA). 2 Five min after a single electrically induced seizure there was a rise in GABA content in these brain regions and an almost total inhibition of the rate of synthesis. 3 Five min after seizure induced by the inhalant convulsant flurothyl there was no rise in GABA content in these brain regions but a similar marked degree of inhibition of GABA synthesis. 4 Two hours after the convulsion the rate of GABA synthesis had returned to control values in all three brain regions. 5 A single convulsion did not alter the glutamic acid decarboxylase activity in these brain regions either in the absence or presence of added co-factor (pyridoxal phosphate). 6 Evidence for an inhibition of GABA release following a convulsion which may be associated with the inhibition of GABA synthesis is presented in the following paper.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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