Abstract
1 The effect of in vivo oestrogen treatment on both 45Ca influx in myometrial strips and the kinetics of [3H)-nitrendipine binding in the isolated plasma membrane (PM) was studied. 2 After four days of continuous oestrogen treatment of ovariectomized rats, 45Ca influx in both resting (unstimulated) and K-stimulated myometrium was substantially increased. 3 Oestrogen treatment significantly increased the density in PM of nitrendipine binding sites and also caused a slight and insignificant increase in the affinity for nitrendipine. 4 The data suggest that the increase in Ca entry following oestrogen treatment probably results from an increase in calcium channel density.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Batra S., Bengtsson B. Effects of diethylstilboestrol and ovarian steroids on the contractile responses and calcium movements in rat uterine smooth muscle. J Physiol. 1978 Mar;276:329–342. doi: 10.1113/jphysiol.1978.sp012237. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Batra S. Characterization of [3H]-nitrendipine binding to uterine smooth muscle plasma membrane and its relevance to inhibition of calcium entry. Br J Pharmacol. 1985 Aug;85(4):767–774. doi: 10.1111/j.1476-5381.1985.tb11074.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Batra S. Effect of estrogen and progesterone treatment on calcium uptake by the myometrium and smooth muscle of the lower urinary tract. Eur J Pharmacol. 1986 Aug 7;127(1-2):37–42. doi: 10.1016/0014-2999(86)90203-7. [DOI] [PubMed] [Google Scholar]
- Batra S., Sjöberg N. O., Thorbert G. Estrogen and progesterone interactions in the rabbit uterus in vivo after steroid administration. Endocrinology. 1978 Jan;102(1):268–272. doi: 10.1210/endo-102-1-268. [DOI] [PubMed] [Google Scholar]
- Batra S., Sjögren C. Effect of estrogen treatment on calcium uptake by the rat uterine smooth muscle. Life Sci. 1983 Jan 24;32(4):315–319. doi: 10.1016/0024-3205(83)90076-0. [DOI] [PubMed] [Google Scholar]
- Fuchs A. R., Periyasamy S., Alexandrova M., Soloff M. S. Correlation between oxytocin receptor concentration and responsiveness to oxytocin in pregnant rat myometrium: effects of ovarian steroids. Endocrinology. 1983 Aug;113(2):742–749. doi: 10.1210/endo-113-2-742. [DOI] [PubMed] [Google Scholar]
- Godfraind T. Calcium exchange in vascular smooth muscle, action of noradrenaline and lanthanum. J Physiol. 1976 Aug;260(1):21–35. doi: 10.1113/jphysiol.1976.sp011501. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jaqua-Stewart M. J., Read W. O., Steffen R. P. Isolation of pure myocardial subcellular organelles. Anal Biochem. 1979 Jul 15;96(2):293–297. doi: 10.1016/0003-2697(79)90584-0. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Larsson B., Andersson K. E., Batra S., Mattiasson A., Sjögren C. Effects of estradiol on norepinephrine-induced contraction, alpha adrenoceptor number and norepinephrine content in the female rabbit urethra. J Pharmacol Exp Ther. 1984 May;229(2):557–563. [PubMed] [Google Scholar]
- Levin R. M., Shofer F. S., Wein A. J. Estrogen-induced alterations in the autonomic responses of the rabbit urinary bladder. J Pharmacol Exp Ther. 1980 Dec;215(3):614–618. [PubMed] [Google Scholar]
- Van Breemen C., Farinas B. R., Gerba P., McNaughton E. D. Excitation-contraction coupling in rabbit aorta studied by the lanthanum method for measuring cellular calcium influx. Circ Res. 1972 Jan;30(1):44–54. doi: 10.1161/01.res.30.1.44. [DOI] [PubMed] [Google Scholar]
- Williams L. T., Lefkowitz R. J. Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone. J Clin Invest. 1977 Oct;60(4):815–818. doi: 10.1172/JCI108835. [DOI] [PMC free article] [PubMed] [Google Scholar]