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. 1983 Dec;24(6):947–949. doi: 10.1128/aac.24.6.947

Establishment of a murine cell line resistant to arabinosyladenine and devoid of adenosine deaminase activity.

C Shipman Jr, S L Tong, S H Smith, N B Katlama, J C Drach
PMCID: PMC185413  PMID: 6660862

Abstract

A population of cells stably resistant to a concentration of arabinosyladenine 100-fold greater than that tolerated by wild-type cells was selected over a period of 15 months. The cells are not cross resistant to arabinosylcytosine and may have at least one kinase with altered substrate specificity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ayusawa D., Iwata K., Seno T. Alteration of ribonucleotide reductase in aphidicolin-resistant mutants of mouse FM3A cells with associated resistance to arabinosyladenine and arabinosylcytosine. Somatic Cell Genet. 1981 Jan;7(1):27–42. doi: 10.1007/BF01544746. [DOI] [PubMed] [Google Scholar]
  2. Chan V. L., Juranka P. Isolation and preliminary characterization of 9-beta-d-arabinofuranosyladenine-resistant mutants of baby hamster cells. Somatic Cell Genet. 1981 Mar;7(2):147–160. doi: 10.1007/BF01567654. [DOI] [PubMed] [Google Scholar]
  3. Drach J. C., Sandberg J. N., Shipman C., Jr Antiproliferative effects of 9-beta-d-arabinofuranosyladenine in a mammalian cell line devoid of adenosine deaminase activity. J Dent Res. 1977 Mar;56(3):275–288. doi: 10.1177/00220345770560031301. [DOI] [PubMed] [Google Scholar]
  4. Hunt S. W., 3rd, Hoffee P. A. Increased adenosine deaminase synthesis and messenger RNA activity in deoxycoformycin-resistant cells. J Biol Chem. 1983 Jan 10;258(1):41–44. [PubMed] [Google Scholar]
  5. LePage G. A. Resistance to 9-beta-D-arabinofuranosyladenine in murine tumor cells. Cancer Res. 1978 Aug;38(8):2314–2316. [PubMed] [Google Scholar]
  6. Pfefferkorn E. R., Pfefferkorn L. C. The biochemical basis for resistance to adenine arabinoside in a mutant of Toxoplasma gondii. J Parasitol. 1978 Jun;64(3):486–492. [PubMed] [Google Scholar]
  7. Rossana C., Gollakota Rao L., Johnson L. F. Thymidylate synthetase overproduction in 5-fluorodeoxyuridine-resistant mouse fibroblasts. Mol Cell Biol. 1982 Sep;2(9):1118–1125. doi: 10.1128/mcb.2.9.1118. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Shipman C., Jr, Drach J. C. Absence of adenosine deaminase activity in a mammalian cell line transformed by Rous sarcoma virus. Science. 1978 Jun 9;200(4346):1163–1165. doi: 10.1126/science.206965. [DOI] [PubMed] [Google Scholar]
  9. Shipman C., Jr Evaluation of 4-(2-hydroxyethyl)-1-piperazineëthanesulfonic acid (HEPES) as a tissue culture buffer. Proc Soc Exp Biol Med. 1969 Jan;130(1):305–310. doi: 10.3181/00379727-130-33543. [DOI] [PubMed] [Google Scholar]
  10. Shipman C., Jr, Smith S. H., Carlson R. H., Drach J. C. Antiviral activity of arabinosyladenine and arabinosylhypoxanthine in herpes simplex virus-infected KB cells: selective inhibition of viral deoxyribonucleic acid synthesis in synchronized suspension cultures. Antimicrob Agents Chemother. 1976 Jan;9(1):120–127. doi: 10.1128/aac.9.1.120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Shipman C., Jr, Smith S. H., Drach J. C. Selective inhibition of nuclear DNA synthesis by 9- -D-arabinofuranosyl adenine in rat cells transformed by Rous sarcoma virus. Proc Natl Acad Sci U S A. 1972 Jul;69(7):1753–1757. doi: 10.1073/pnas.69.7.1753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sudo T., Onodera K. Isolation and characterization of tunicamycin resistant mutants from Chinese hamster ovary cells. J Cell Physiol. 1979 Oct;101(1):149–156. doi: 10.1002/jcp.1041010117. [DOI] [PubMed] [Google Scholar]
  13. Verhoef V., Sarup J., Fridland A. Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases. Cancer Res. 1981 Nov;41(11 Pt 1):4478–4483. [PubMed] [Google Scholar]
  14. Whitley R., Alford C., Hess F., Buchanan R. Vidarabine: a preliminary review of its pharmacological properties and therapeutic use. Drugs. 1980 Oct;20(4):267–282. doi: 10.2165/00003495-198020040-00002. [DOI] [PubMed] [Google Scholar]

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