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. 1988 Sep;95(1):268–274. doi: 10.1111/j.1476-5381.1988.tb16573.x

Pre- and post-junctional actions of procaterol, a beta 2-adrenoceptor stimulant, on dog tracheal tissue.

Y Ito 1
PMCID: PMC1854133  PMID: 2905905

Abstract

1. The effects of procaterol, a beta 2-adrenoceptor agonist, on excitatory neuro-effector transmission in the dog trachea were investigated and the findings were compared to those seen with isoprenaline, with microelectrode, double sucrose gap and tension recording methods. 2. Procaterol (10(-10)-10(-9) M) and isoprenaline (10(-9) M) had no effect on the resting membrane potential or on the input resistance of the smooth muscle cells of dog trachea. However with increased concentrations (greater than 10(-8) M), these agents hyperpolarized the membrane and decreased the input resistance of the membrane. 3. Procaterol (10(-10)-10(-7) M) and isoprenaline (10(-9)-10(-7) M) dose-dependently reduced the amplitude of the twitch contractions evoked by field stimulation in the combined presence of indomethacin (10(-5) M) and guanethidine (10(-6) M). In parallel with actions on twitch contractions, procaterol (10(-10)-10(-7) M) and isoprenaline (10(-9)-10(-7) M) reduced the amplitude of the excitatory junction potentials (e.j.ps), evoked by single pulse field stimulation in the dog trachea. 4. Procaterol (10(-8) M) had no effect on the post-junctional response of smooth muscle cells to exogenous acetylcholine (ACh) (10(-7)-10(-6) M). 5. Pretreatment with ICI-118551, a beta 2-adrenoceptor blocking agent, reduced the inhibitory action of procaterol on the amplitude of twitch contractions evoked by field stimulations in the dog trachea.(ABSTRACT TRUNCATED AT 250 WORDS)

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Selected References

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  1. Bilski A. J., Halliday S. E., Fitzgerald J. D., Wale J. L. The pharmacology of a beta 2-selective adrenoceptor antagonist (ICI 118,551). J Cardiovasc Pharmacol. 1983 May-Jun;5(3):430–437. doi: 10.1097/00005344-198305000-00013. [DOI] [PubMed] [Google Scholar]
  2. Carswell H., Nahorski S. R. Beta-adrenoceptor heterogeneity in guinea-pig airways: comparison of functional and receptor labelling studies. Br J Pharmacol. 1983 Aug;79(4):965–971. doi: 10.1111/j.1476-5381.1983.tb10542.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Danser A. H., van den Ende R., Lorenz R. R., Flavahan N. A., Vanhoutte P. M. Prejunctional beta 1-adrenoceptors inhibit cholinergic transmission in canine bronchi. J Appl Physiol (1985) 1987 Feb;62(2):785–790. doi: 10.1152/jappl.1987.62.2.785. [DOI] [PubMed] [Google Scholar]
  4. Delhaye M., Taton G., Camus J. C., Chatelain P., Robberecht P., Waelbroeck M., Christophe J. Effects of full and partial beta-adrenergic agonists and antagonists on human lung adenylate cyclase. Biochem Pharmacol. 1983 Jun 15;32(12):1831–1835. doi: 10.1016/0006-2952(83)90046-1. [DOI] [PubMed] [Google Scholar]
  5. Fujiwara T., Sumimoto K., Itoh T., Suzuki H., Kuriyama H. Relaxing actions of procaterol, a beta 2-adrenoceptor stimulant, on smooth muscle cells of the dog trachea. Br J Pharmacol. 1988 Jan;93(1):199–209. doi: 10.1111/j.1476-5381.1988.tb11422.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Himori N., Taira N. Assessment of the selectivity of OPC-2009, a new beta2-adrenoceptor stimulatn, by the use of the blood-perfused trachea in situ and of the isolated blood-perfused papillary muscle of the dog. Br J Pharmacol. 1977 Sep;61(1):9–17. doi: 10.1111/j.1476-5381.1977.tb09734.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Inoue T., Ito Y. Characteristics of neuro-effector transmission in the smooth muscle layer of dog bronchiole and modifications by autacoids. J Physiol. 1986 Jan;370:551–565. doi: 10.1113/jphysiol.1986.sp015950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Inoue T., Ito Y., Takeda K. Prostaglandin-induced inhibition of acetylcholine release from neuronal elements of dog tracheal tissue. J Physiol. 1984 Apr;349:553–570. doi: 10.1113/jphysiol.1984.sp015173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ito Y., Tajima K. Actions of indomethacin and prostaglandins on neuro-effector transmission in the dog trachea. J Physiol. 1981;319:379–392. doi: 10.1113/jphysiol.1981.sp013915. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ito Y., Tajima K. Dual effects of catecholamines on pre- and post-junctional membranes in the dog trachea. Br J Pharmacol. 1982 Mar;75(3):433–440. doi: 10.1111/j.1476-5381.1982.tb09158.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ito Y., Tajima K. Spontaneous activity in the trachea of dogs treated with indomethacin: an experimental model for aspirin-related asthma. Br J Pharmacol. 1981 Jun;73(2):563–571. doi: 10.1111/j.1476-5381.1981.tb10456.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Russell J. A. Noradrenergic inhibitory innervation of canine airways. J Appl Physiol Respir Environ Exerc Physiol. 1980 Jan;48(1):16–22. doi: 10.1152/jappl.1980.48.1.16. [DOI] [PubMed] [Google Scholar]
  13. Shore S., Collier B., Martin J. G. Effect of endogenous prostaglandins on acetylcholine release from dog trachealis muscle. J Appl Physiol (1985) 1987 May;62(5):1837–1844. doi: 10.1152/jappl.1987.62.5.1837. [DOI] [PubMed] [Google Scholar]
  14. Takayanagi I., Kondo N., Yamashita H., Hongo T., Takagi K. New selective beta2-adrenoreceptor stimulants 5(1-hydroxy-2-isopropylaminobutyl)- and 5-(1-hydroxy-2-ethylaminobutyl)-8-hydroxycarbostyril hydrochlorides (OPC-2009 and OPC-2030) and cyclic AMP concentration. J Pharm Pharmacol. 1977 Mar;29(3):187–189. doi: 10.1111/j.2042-7158.1977.tb11284.x. [DOI] [PubMed] [Google Scholar]
  15. Walters E. H., O'Byrne P. M., Fabbri L. M., Graf P. D., Holtzman M. J., Nadel J. A. Control of neurotransmission by prostaglandins in canine trachealis smooth muscle. J Appl Physiol Respir Environ Exerc Physiol. 1984 Jul;57(1):129–134. doi: 10.1152/jappl.1984.57.1.129. [DOI] [PubMed] [Google Scholar]
  16. Yabuuchi Y. The beta-adrenoceptor stimulant properties of OPC-2009 on guinea-pig isolated tracheal, right atrial and left atrial preparations. Br J Pharmacol. 1977 Dec;61(4):513–521. doi: 10.1111/j.1476-5381.1977.tb07543.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Yabuuchi Y., Yamashita S., Tei S. S. Pharmacological studies of OPC-2009, a newly synthesized selective beta adrenoceptor stimulant, in the broncho-motor and cardiovascular system of the anesthetized dog. J Pharmacol Exp Ther. 1977 Aug;202(2):326–336. [PubMed] [Google Scholar]
  18. Yamashita S., Takai M., Yabuuchi Y. Actions of procaterol (OPC-2009), a new beta2-adrenoceptor stimulant, on pulmonary resistance, contractions of the soleus muscle, and cardiovascular system of the anaesthetized cat. J Pharm Pharmacol. 1978 May;30(5):273–279. doi: 10.1111/j.2042-7158.1978.tb13228.x. [DOI] [PubMed] [Google Scholar]
  19. Yoshizaki S., Tanimura K., Tamada S., Yabuuchi Y., Nakagawa K. Sympathomimetic amines having a carbostyril nucleus. J Med Chem. 1976 Sep;19(9):1138–1142. doi: 10.1021/jm00231a011. [DOI] [PubMed] [Google Scholar]

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