Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1984 Jan;25(1):149–151. doi: 10.1128/aac.25.1.149

Kinetic studies on the inhibition of Proteus vulgaris beta-lactamase by imipenem.

T Hashizume, A Yamaguchi, T Hirata, T Sawai
PMCID: PMC185458  PMID: 6367634

Abstract

Imipenem was found to inhibit Proteus vulgaris beta-lactamase in a progressive manner. Kinetic experiments confirmed that the inactivated enzyme was not completely recovered after intact imipenem had been exhausted.

Full text

PDF
150

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brenner D. G., Knowles J. R. Penicillanic acid sulfone: an unexpected isotope effect in the interaction of 6 alpha- and 6 beta-monodeuterio and of 6,6-dideuterio derivatives with RTEM beta-lactamase from Escherichia coli. Biochemistry. 1981 Jun 23;20(13):3680–3687. doi: 10.1021/bi00516a003. [DOI] [PubMed] [Google Scholar]
  2. Charnas R. L., Fisher J., Knowles J. R. Chemical studies on the inactivation of Escherichia coli RTEM beta-lactamase by clavulanic acid. Biochemistry. 1978 May 30;17(11):2185–2189. doi: 10.1021/bi00604a025. [DOI] [PubMed] [Google Scholar]
  3. Charnas R. L., Knowles J. R. Inhibition of the RTEM beta-lactamase from Escherichia coli. Interaction of enzyme with derivatives of olivanic acid. Biochemistry. 1981 May 12;20(10):2732–2737. doi: 10.1021/bi00513a005. [DOI] [PubMed] [Google Scholar]
  4. DAVIS B. J. DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS. Ann N Y Acad Sci. 1964 Dec 28;121:404–427. doi: 10.1111/j.1749-6632.1964.tb14213.x. [DOI] [PubMed] [Google Scholar]
  5. Easton C. J., Knowles J. R. Inhibition of the RTEM beta-lactamase from Escherichia coli. Interaction of the enzyme with derivatives of olivanic acid. Biochemistry. 1982 Jun 8;21(12):2857–2862. doi: 10.1021/bi00541a008. [DOI] [PubMed] [Google Scholar]
  6. Fisher J., Charnas R. L., Knowles J. R. Kinetic studies on the inactivation of Escherichia coli RTEM beta-lactamase by clavulanic acid. Biochemistry. 1978 May 30;17(11):2180–2184. doi: 10.1021/bi00604a024. [DOI] [PubMed] [Google Scholar]
  7. Kahan J. S., Kahan F. M., Goegelman R., Currie S. A., Jackson M., Stapley E. O., Miller T. W., Miller A. K., Hendlin D., Mochales S. Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties. J Antibiot (Tokyo) 1979 Jan;32(1):1–12. doi: 10.7164/antibiotics.32.1. [DOI] [PubMed] [Google Scholar]
  8. Labia R., Peduzzi J. Cinetique de l'inhibition de beta-lactamases par l'acide clavulanique. Biochim Biophys Acta. 1978 Oct 12;526(2):572–579. doi: 10.1016/0005-2744(78)90147-x. [DOI] [PubMed] [Google Scholar]
  9. Okamura K., Sakamoto M., Ishikura T. PS-5 inhibition of a beta-lactamase from Proteus vulgaris. J Antibiot (Tokyo) 1980 Mar;33(3):293–302. doi: 10.7164/antibiotics.33.293. [DOI] [PubMed] [Google Scholar]
  10. Okonogi K., Harada S., Shinagawa S., Imada A., Kuno M. Beta-lactamase inhibitory activities and synergistic effects of 5,6-cis-carbapenem antibiotics. J Antibiot (Tokyo) 1982 Aug;35(8):963–971. doi: 10.7164/antibiotics.35.963. [DOI] [PubMed] [Google Scholar]
  11. REISFELD R. A., LEWIS U. J., WILLIAMS D. E. Disk electrophoresis of basic proteins and peptides on polyacrylamide gels. Nature. 1962 Jul 21;195:281–283. doi: 10.1038/195281a0. [DOI] [PubMed] [Google Scholar]
  12. RIchmond M. H. The semi-synthetic thienamycin derivative MK0787 and its properties with respect to a range of beta-lactamases from clinically relevant bacterial species. J Antimicrob Chemother. 1981 Mar;7(3):279–285. doi: 10.1093/jac/7.3.279. [DOI] [PubMed] [Google Scholar]
  13. Sawai T., Kanno M., Tsukamoto K. Characterization of eight beta-lactamases of Gram-negative bacteria. J Bacteriol. 1982 Nov;152(2):567–571. doi: 10.1128/jb.152.2.567-571.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sawai T., Tsukamoto K. Cefoxitin, N-formimidoyl thienamycin, clavulanic acid, and penicillanic acid sulfone as suicide inhibitors for different types of beta-lactamases produced by gram-negative bacteria. J Antibiot (Tokyo) 1982 Nov;35(11):1594–1602. doi: 10.7164/antibiotics.35.1594. [DOI] [PubMed] [Google Scholar]
  15. Sawai T., Yoshida T., Tsukamoto K., Yamagishi S. A set of bacterial strains for evaluation of beta-lactamase-stability of beta-lactam antibiotics. J Antibiot (Tokyo) 1981 Oct;34(10):1318–1326. doi: 10.7164/antibiotics.34.1318. [DOI] [PubMed] [Google Scholar]
  16. Yamaguchi A., Hirata T., Sawai T. Kinetic studies on inactivation of Citrobacter freundii cephalosporinase by sulbactam. Antimicrob Agents Chemother. 1983 Jul;24(1):23–30. doi: 10.1128/aac.24.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES