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. 1984 Feb;25(2):292–295. doi: 10.1128/aac.25.2.292

Biological action of inosine analogs in Leishmania and Trypanosoma spp.

J J Marr, R L Berens, N K Cohn, D J Nelson, R S Klein
PMCID: PMC185495  PMID: 6712205

Abstract

Previous investigations have suggested that inosine analogs would be good models for the development of chemotherapeutic agents active against pathogenic hemoflagellates. We have systematically modified the five-membered heterocyclic ring of six inosine analogs and tested them for their antiprotozoal activities and toxicity to a mammalian cell line. All six analogs were very active against the three protozoan pathogens Leishmania donovani, Trypanosoma cruzi, and Trypanosoma gambiense. Two of the six, 9-deazainosine and allopurinol ribonucleoside, had very little toxicity for mouse L cells and offer promise as potential chemotherapeutic agents.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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