Abstract
The susceptibility of 100 group B streptococci to 16 beta-lactam antibiotics was tested by agar dilution. Penicillin G and N-formimidoyl thienamycin were the most active agents tested, both having a 90% minimal inhibitory concentration (MIC90) of 0.06 microgram/ml. Ceftriaxone, cefotaxime, cefamandole, and SCH 29482 were almost as active, all having an MIC90 of 0.12 microgram/ml, and ampicillin, cephalothin, and mezlocillin all had an MIC90 of 0.25 microgram/ml. The MIC90 for piperacillin, cefoperazone, and ceftazidime was 0.5 microgram/ml. Least active were carbenicillin, ticarcillin, cefoxitin, and moxalactam, with MIC90s of 1, 2, 4, and 8 micrograms/ml, respectively. No penicillin-tolerant strains were detected.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baker C. N., Thornsberry C., Facklam R. R. Synergism, killing kinetics, and antimicrobial susceptibility of group A and B streptococci. Antimicrob Agents Chemother. 1981 May;19(5):716–725. doi: 10.1128/aac.19.5.716. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Christensen P., Kahlmeter G., Jonsson S., Kronvall G. New method for the serological grouping of Streptococci with specific antibodies adsorbed to protein A-containing staphylococci. Infect Immun. 1973 Jun;7(6):881–885. doi: 10.1128/iai.7.6.881-885.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Feldman W. E. Concentrations of bacteria in cerebrospinal fluid of patients with bacterial meningitis. J Pediatr. 1976 Apr;88(4 Pt 1):549–552. doi: 10.1016/s0022-3476(76)80003-0. [DOI] [PubMed] [Google Scholar]
- Horne D., Tomasz A. Hypersusceptibility of penicillin-treated group B streptococci to bactericidal activity of human polymorphonuclear leukocytes. Antimicrob Agents Chemother. 1981 May;19(5):745–753. doi: 10.1128/aac.19.5.745. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jokipii A. M., Jokipii L. Presumptive identification and antibiotic susceptibility of group B streptococci. J Clin Pathol. 1976 Aug;29(8):736–739. doi: 10.1136/jcp.29.8.736. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kaplan J. M., McCracken G. H., Jr, Horton L. J., Thomas M. L., Davis N. Pharmacologic studies in neonates given large dosages of ampicillin. J Pediatr. 1974 Apr;84(4):571–577. doi: 10.1016/s0022-3476(74)80684-0. [DOI] [PubMed] [Google Scholar]
- Kim K. S., Anthony B. F. Penicillin tolerance in group B streptococci isolated from infected neonates. J Infect Dis. 1981 Nov;144(5):411–419. doi: 10.1093/infdis/144.5.411. [DOI] [PubMed] [Google Scholar]
- Kim K. S., Yoshimori R. N., Imagawa D. T., Anthony B. F. Importance of medium in demonstrating penicillin tolerance by group B streptococci. Antimicrob Agents Chemother. 1979 Aug;16(2):214–216. doi: 10.1128/aac.16.2.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Landesman S. H., Corrado M. L., Shah P. M., Armengaud M., Barza M., Cherubin C. E. Past and current roles for cephalosporin antibiotics in treatment of meningitis. Emphasis on use in gram-negative bacillary meningitis. Am J Med. 1981 Oct;71(4):693–703. doi: 10.1016/0002-9343(81)90240-0. [DOI] [PubMed] [Google Scholar]
- McCracken G. H., Jr Neonatal septicemia and meningitis. Hosp Pract. 1976 Jan;11(1):89–97. doi: 10.1080/21548331.1976.11706483. [DOI] [PubMed] [Google Scholar]
- Weeks J. L., Mason E. O., Jr, Baker C. J. Antagonism of ampicillin and chloramphenicol for meningeal isolates of group B streptococci. Antimicrob Agents Chemother. 1981 Sep;20(3):281–285. doi: 10.1128/aac.20.3.281. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilkinson P. J. beta-Lactam antibiotics in the newborn. J Antimicrob Chemother. 1982 Feb;9 (Suppl B):21–29. doi: 10.1093/jac/9.suppl_b.21. [DOI] [PubMed] [Google Scholar]