Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1982 Nov;22(5):923–925. doi: 10.1128/aac.22.5.923

Susceptibility of Haemophilus influenzae type b to cefaclor and influence of inoculum size.

R M Levin, P H Azimi, M G Dunphy
PMCID: PMC185688  PMID: 6983863

Abstract

Cefaclor appeared to be an effective antibiotic against both beta-lactamase-positive and beta-lactamase-negative strains of Haemophilus influenzae type b when tested with 10(5) colony-forming units per ml. With inocula in excess of 10(6) colony-forming units per ml, these organisms were neither inhibited nor killed at concentrations of 400 micrograms/ml. This inoculum effect was also demonstrated in time-kill curve studies.

Full text

PDF
924

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Azimi P. H., Chase P. A. The role of cefamandole in the treatment of Haemophilus influenzae infections in infants and children. J Pediatr. 1981 Jun;98(6):995–1000. doi: 10.1016/s0022-3476(81)80616-6. [DOI] [PubMed] [Google Scholar]
  2. Bill N. J., Washington J. A., 2nd Comparison of in vitro activity of cephalexin, cephradine, and cefaclor. Antimicrob Agents Chemother. 1977 Mar;11(3):470–474. doi: 10.1128/aac.11.3.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Halsted C., Lepow M. L., Balassanian N., Emmerich J., Wolinsky E. Otitis media. Clinical observations, microbiology, and evaluation of therapy. Am J Dis Child. 1968 May;115(5):542–551. doi: 10.1001/archpedi.1968.02100010544003. [DOI] [PubMed] [Google Scholar]
  4. Jones R. N., Gerlach E. H., Fuchs P. C. In vitro antimicrobial activity comparison of cefaclor (compound 99638), cephradine, and cephalothin. J Antibiot (Tokyo) 1977 Sep;30(9):753–755. doi: 10.7164/antibiotics.30.753. [DOI] [PubMed] [Google Scholar]
  5. LOW Möglichkeiten und Grenzen der antibiotischen Therapie in der Behandlung von Krankheiten des Respirationstraktes. Monatsschr Kinderheilkd. 1956 Mar;104(3):106–107. [PubMed] [Google Scholar]
  6. Nelson J. D., Ginsburg C. M., Clahsen J. C., Jackson L. H. Treatment of acute otitis media of infancy with cefaclor. Am J Dis Child. 1978 Oct;132(10):992–996. doi: 10.1001/archpedi.1978.02120350056011. [DOI] [PubMed] [Google Scholar]
  7. Neu H. C., Fu K. P. Cefaclor: in vitro spectrum of activity and beta-lactamase stability. Antimicrob Agents Chemother. 1978 Apr;13(4):584–588. doi: 10.1128/aac.13.4.584. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. RILEY H. D., Jr, KNIGHT V. Urinary tract infection in paralytic poliomyelitis. Medicine (Baltimore) 1958 Dec;37(4):281–297. doi: 10.1097/00005792-195812000-00001. [DOI] [PubMed] [Google Scholar]
  9. RILEY H. D., Jr PYELONEPHRITIS IN INFANCY AND CHILDHOOD. Pediatr Clin North Am. 1964 Aug;11:731–758. doi: 10.1016/s0031-3955(16)31592-9. [DOI] [PubMed] [Google Scholar]
  10. Sinai R., Hammerberg S., Marks M. I., Pai C. H. In vitro susceptibility of Haemophilus influenzae to sulfamethoxazole-trimethoprim and cefaclor, cephalexin, and cephradine. Antimicrob Agents Chemother. 1978 May;13(5):861–864. doi: 10.1128/aac.13.5.861. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES