Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1982 Dec;22(6):1082–1083. doi: 10.1128/aac.22.6.1082

Synergism Between N-Formimidoyl Thienamycin and Gentamicin or Tobramycin Against Enterococci

Chatrchai Watanakunakorn 1,2, Joann C Tisone 1
PMCID: PMC185728  PMID: 6818900

Abstract

By the time-kill curve method, the combination of N-formimidoyl thienamycin and gentamicin showed synergism against 47 of 48 strains of enterococci, whereas the combination of N-formimidoyl thienamycin and tobramycin was synergistic against 46 strains.

Full text

PDF
1082

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Hanslo D., King A., Shannon K., Warren C., Phillips I. N-Formimidoyl thienamycin (MK0787): in-vitro antibacterial activity and susceptibility to beta-lactamases compared with that of cefotaxime, moxalactam and other beta-lactam antibiotics. J Antimicrob Chemother. 1981 Jun;7(6):607–617. doi: 10.1093/jac/7.6.607. [DOI] [PubMed] [Google Scholar]
  2. Livingston W. K., Elliott A. M., Cobbs C. G. In vitro activity of N-formimidoyl thienamycin (MK0787) against resistant strains of Pseudomonas aeruginosa, Staphylococcus epidermidis, Serratia marcescens, and Enterococcus spp. Antimicrob Agents Chemother. 1981 Jan;19(1):114–116. doi: 10.1128/aac.19.1.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Moellering R. C., Jr, Wennersten C., Weinstein A. J. Penicillin-tobramycin synergism against enterococci: a comparison with penicillin and gentamicin. Antimicrob Agents Chemother. 1973 Apr;3(4):526–529. doi: 10.1128/aac.3.4.526. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Watanakunakorn C., Bakie C. Synergism of vancomycin-gentamicin and vancomycin-streptomycin against enterococci. Antimicrob Agents Chemother. 1973 Aug;4(2):120–124. doi: 10.1128/aac.4.2.120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Watanakunakorn C. Penicillin combined with gentamicin or streptomycin: synergism against enterococci. J Infect Dis. 1971 Dec;124(6):581–586. doi: 10.1093/infdis/124.6.581. [DOI] [PubMed] [Google Scholar]
  6. Wise R., Andrews J. M., Patel N. N-formimidoyl-thienamycin a novel beta-lactam: an in-vitro comparison with other beta-lactam antibiotics. J Antimicrob Chemother. 1981 May;7(5):521–529. doi: 10.1093/jac/7.5.521. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES