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. 1998 Jun;152(6):1531–1539.

Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy.

M Pérez 1, J M Valpuesta 1, E M de Garcini 1, C Quintana 1, M Arrasate 1, J L López Carrascosa 1, A Rábano 1, J García de Yébenes 1, J Avila 1
PMCID: PMC1858430  PMID: 9626057

Abstract

Tau-containing filaments purified from the brain of progressive supranuclear palsy (PSP) patients were isolated and characterized. These filaments co-purify with regular particles that biophysical and biochemical methods identified as ferritin shells. In vivo, brain tau accumulation in PSP co-localized with ferritin. These results suggest that ferritin/iron could modulate the formation of tau aggregates in PSP.

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Selected References

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