Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1983 Feb;23(2):252–255. doi: 10.1128/aac.23.2.252

Single-dose pharmacokinetics of intravenous clavulanic acid with amoxicillin in pediatric patients.

U B Schaad, P A Casey, D L Cooper
PMCID: PMC186032  PMID: 6838187

Abstract

Pharmacokinetics of a parenteral formulation comprised of 5 parts of amoxicillin and 1 part of clavulanic acid were determined in 12 pediatric patients, 2 to 14 years of age. A single dose amounting to 25 mg of amoxicillin and 5 mg of clavulanic acid per kg of body weight was infused intravenously over 2 min. Mean plasma concentrations 5 min after dosing were 89.4 micrograms of amoxicillin per ml and 19.5 micrograms of clavulanic acid per ml. Terminal phase plasma half-lives were 1.2 and 0.8 h, respectively. The data acquired in this study indicate that amoxicillin and clavulanic acid are pharmacokinetically compatible. Moreover, taken with assessment of microbiological activities by others, the present data suggest that intravenous administration of 25 mg of amoxicillin plus 5 mg of clavulanic acid per kg every 6 h is a reasonable starting regimen for assessing the activity of the combined drug formulation in noninvasive childhood diseases caused by Haemophilus influenzae, Staphylococcus aureus, Streptococci spp., Neisseria spp., Branhamella catarrhalis, and other susceptible organisms.

Full text

PDF
255

Images in this article

254Image
on p.254

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ball A. P., Geddes A. M., Davey P. G., Farrell I. D., Brookes G. R. Clavulanic acid and amoxycillin: a clinical, bacteriological, and pharmacological study. Lancet. 1980 Mar 22;1(8169):620–623. doi: 10.1016/s0140-6736(80)91118-6. [DOI] [PubMed] [Google Scholar]
  2. Beeuwkes H., Rutgers V. H. A combination of amoxicillin and clavulanic acid in the treatment of respiratory tract infections caused by amoxicillin-resistant haemophilus influenzae. Infection. 1981;9(5):244–248. doi: 10.1007/BF01640725. [DOI] [PubMed] [Google Scholar]
  3. Boon R. J., Beale A. S., Comber K. R., Pierce C. V., Sutherland R. Distribution of amoxicillin and clavulanic acid in infected animals and efficacy against experimental infections. Antimicrob Agents Chemother. 1982 Sep;22(3):369–375. doi: 10.1128/aac.22.3.369. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Craft J. C., Feldman W. E., Nelson J. D. Clinicopharmacological evaluation of amoxicillin and probenecid against bacterial meningitis. Antimicrob Agents Chemother. 1979 Sep;16(3):346–352. doi: 10.1128/aac.16.3.346. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hunter P. A., Coleman K., Fisher J., Taylor D. In vitro synergistic properties of clavulanic acid, with ampicillin, amoxycillin and ticarcillin. J Antimicrob Chemother. 1980 Jul;6(4):455–470. doi: 10.1093/jac/6.4.455. [DOI] [PubMed] [Google Scholar]
  6. Nelson J. D., Kusmiesz H., Shelton S. Pharmacokinetics of potassium clavulanate in combination with amoxicillin in pediatric patients. Antimicrob Agents Chemother. 1982 Apr;21(4):681–682. doi: 10.1128/aac.21.4.681. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Neu H. C., Fu K. P. Clavulanic acid, a novel inhibitor of beta-lactamases. Antimicrob Agents Chemother. 1978 Nov;14(5):650–655. doi: 10.1128/aac.14.5.650. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ninane G., Joly J., Kraytman M., Piot P. Bronchopulmonary infection due to beta-lactamase-producing Branhamella catarrhalis treated with amoxycillin/clavulanic-acid. Lancet. 1978 Jul 29;2(8083):257–257. doi: 10.1016/s0140-6736(78)91763-4. [DOI] [PubMed] [Google Scholar]
  9. Peters G., Pulverer G., Neugebauer M. In vitro-activity of clavulanic acid and amoxicillin combined against amoxicillin-resistant bacteria. Infection. 1980;8(3):104–106. doi: 10.1007/BF01641472. [DOI] [PubMed] [Google Scholar]
  10. Rudoy R. C., Goto N., Pettit D., Uemura H. Pharmacokinetics of intravenous amoxicillin in pediatric patients. Antimicrob Agents Chemother. 1979 Apr;15(4):628–629. doi: 10.1128/aac.15.4.628. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Washburn R. G., Durack D. T. Efficacy of ampicillin plus a beta-lactamase inhibitor (CP-45,899) in experimental endocarditis due to Staphylococcus aureus. J Infect Dis. 1981 Sep;144(3):237–243. doi: 10.1093/infdis/144.3.237. [DOI] [PubMed] [Google Scholar]
  12. Yogev R., Melick C., Kabat W. J. In vitro and in vivo synergism between amoxicillin and clavulanic acid against ampicillin-resistant Haemophilus influenzae type b. Antimicrob Agents Chemother. 1981 Jun;19(6):993–996. doi: 10.1128/aac.19.6.993. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES