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. 1996 May;148(5):1331–1337.

Molecular analysis of the pathological autoimmune antigens of Heymann nephritis.

M G Farquhar 1
PMCID: PMC1861576  PMID: 8623903

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Selected References

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  1. Bachinsky D. R., Zheng G., Niles J. L., McLaughlin M., Abbate M., Andres G., Brown D., McCluskey R. T. Detection of two forms of GP330. Their role in Heymann nephritis. Am J Pathol. 1993 Aug;143(2):598–611. [PMC free article] [PubMed] [Google Scholar]
  2. Battey F. D., Gåfvels M. E., FitzGerald D. J., Argraves W. S., Chappell D. A., Strauss J. F., 3rd, Strickland D. K. The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor. J Biol Chem. 1994 Sep 16;269(37):23268–23273. [PubMed] [Google Scholar]
  3. Biemesderfer D., Dekan G., Aronson P. S., Farquhar M. G. Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ER. Am J Physiol. 1993 Jun;264(6 Pt 2):F1011–F1020. doi: 10.1152/ajprenal.1993.264.6.F1011. [DOI] [PubMed] [Google Scholar]
  4. Caulfield J. P., Farquhar M. G. The permeability of glomerular capillaries to graded dextrans. Identification of the basement membrane as the primary filtration barrier. J Cell Biol. 1974 Dec;63(3):883–903. doi: 10.1083/jcb.63.3.883. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cavallo T. Membranous nephropathy. Insights from Heymann nephritis. Am J Pathol. 1994 Apr;144(4):651–658. [PMC free article] [PubMed] [Google Scholar]
  6. Christensen E. I., Gliemann J., Moestrup S. K. Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein. J Histochem Cytochem. 1992 Oct;40(10):1481–1490. doi: 10.1177/40.10.1382088. [DOI] [PubMed] [Google Scholar]
  7. Couser W. G. Mediation of immune glomerular injury. J Am Soc Nephrol. 1990 Jul;1(1):13–29. doi: 10.1681/ASN.V1113. [DOI] [PubMed] [Google Scholar]
  8. Edgington T. S., Glassock R. J., Dixon F. J. Autologous immune-complex pathogenesis of experimental allergic glomerulonephritis. Science. 1967 Mar 17;155(3768):1432–1434. doi: 10.1126/science.155.3768.1432. [DOI] [PubMed] [Google Scholar]
  9. FARQUHAR M. G., PALADE G. E. Glomerular permeability. II. Ferritin transfer across the glomerular capillary wall in nephrotic rats. J Exp Med. 1961 Nov 1;114:699–716. doi: 10.1084/jem.114.5.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Farquhar M. G., Saito A., Kerjaschki D., Orlando R. A. The Heymann nephritis antigenic complex: megalin (gp330) and RAP. J Am Soc Nephrol. 1995 Jul;6(1):35–47. doi: 10.1681/ASN.V6135. [DOI] [PubMed] [Google Scholar]
  11. Farquhar M. G. The unfolding story of megalin (gp330): now recognized as a drug receptor. J Clin Invest. 1995 Sep;96(3):1184–1184. doi: 10.1172/JCI118149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Grupe W. E., Kaplan M. H. Demonstration of an antibody to proximal tubular antigen in the pathogenesis of experimental autoimmune nephrosis in rats. J Lab Clin Med. 1969 Sep;74(3):400–409. [PubMed] [Google Scholar]
  13. HEYMANN W., HACKEL D. B., HARWOOD S., WILSON S. G., HUNTER J. L. Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions. Proc Soc Exp Biol Med. 1959 Apr;100(4):660–664. doi: 10.3181/00379727-100-24736. [DOI] [PubMed] [Google Scholar]
  14. Kanalas J. J., Makker S. P. Identification of the rat Heymann nephritis autoantigen (GP330) as a receptor site for plasminogen. J Biol Chem. 1991 Jun 15;266(17):10825–10829. [PubMed] [Google Scholar]
  15. Kerjaschki D., Farquhar M. G. Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats. J Exp Med. 1983 Feb 1;157(2):667–686. doi: 10.1084/jem.157.2.667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Kerjaschki D., Farquhar M. G. The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci U S A. 1982 Sep;79(18):5557–5561. doi: 10.1073/pnas.79.18.5557. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Kerjaschki D., Miettinen A., Farquhar M. G. Initial events in the formation of immune deposits in passive Heymann nephritis. gp330-anti-gp330 immune complexes form in epithelial coated pits and rapidly become attached to the glomerular basement membrane. J Exp Med. 1987 Jul 1;166(1):109–128. doi: 10.1084/jem.166.1.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kerjaschki D., Noronha-Blob L., Sacktor B., Farquhar M. G. Microdomains of distinctive glycoprotein composition in the kidney proximal tubule brush border. J Cell Biol. 1984 Apr;98(4):1505–1513. doi: 10.1083/jcb.98.4.1505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Kerjaschki D., Ullrich R., Diem K., Pietromonaco S., Orlando R. A., Farquhar M. G. Identification of a pathogenic epitope involved in initiation of Heymann nephritis. Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11179–11183. doi: 10.1073/pnas.89.23.11179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Kounnas M. Z., Argraves W. S., Strickland D. K. The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330. J Biol Chem. 1992 Oct 15;267(29):21162–21166. [PubMed] [Google Scholar]
  21. Krieger M., Herz J. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem. 1994;63:601–637. doi: 10.1146/annurev.bi.63.070194.003125. [DOI] [PubMed] [Google Scholar]
  22. Medh J. D., Fry G. L., Bowen S. L., Pladet M. W., Strickland D. K., Chappell D. A. The 39-kDa receptor-associated protein modulates lipoprotein catabolism by binding to LDL receptors. J Biol Chem. 1995 Jan 13;270(2):536–540. doi: 10.1074/jbc.270.2.536. [DOI] [PubMed] [Google Scholar]
  23. Miettinen A., Törnroth T., Tikkanen I., Virtanen I., Linder E. Heymann nephritis induced by kidney brush border glycoproteins. Lab Invest. 1980 Dec;43(6):547–555. [PubMed] [Google Scholar]
  24. Moestrup S. K., Christensen E. I., Nielsen S., Jørgensen K. E., Bjørn S. E., Røigaard H., Gliemann J. Binding and endocytosis of proteins mediated by epithelial gp330. Ann N Y Acad Sci. 1994 Sep 10;737:124–137. doi: 10.1111/j.1749-6632.1994.tb44306.x. [DOI] [PubMed] [Google Scholar]
  25. Moestrup S. K., Nielsen S., Andreasen P., Jørgensen K. E., Nykjaer A., Røigaard H., Gliemann J., Christensen E. I. Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes. J Biol Chem. 1993 Aug 5;268(22):16564–16570. [PubMed] [Google Scholar]
  26. Orlando R. A., Farquhar M. G. Functional domains of the receptor-associated protein (RAP). Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3161–3165. doi: 10.1073/pnas.91.8.3161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Orlando R. A., Kerjaschki D., Farquhar M. G. Megalin (gp330) possesses an antigenic epitope capable of inducing passive Heymann nephritis independent of the nephritogenic epitope in receptor-associated protein. J Am Soc Nephrol. 1995 Jul;6(1):61–67. doi: 10.1681/ASN.V6161. [DOI] [PubMed] [Google Scholar]
  28. Orlando R. A., Kerjaschki D., Kurihara H., Biemesderfer D., Farquhar M. G. gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6698–6702. doi: 10.1073/pnas.89.15.6698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Pietromonaco S., Kerjaschki D., Binder S., Ullrich R., Farquhar M. G. Molecular cloning of a cDNA encoding a major pathogenic domain of the Heymann nephritis antigen gp330. Proc Natl Acad Sci U S A. 1990 Mar;87(5):1811–1815. doi: 10.1073/pnas.87.5.1811. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Raychowdhury R., Niles J. L., McCluskey R. T., Smith J. A. Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor. Science. 1989 Jun 9;244(4909):1163–1165. doi: 10.1126/science.2786251. [DOI] [PubMed] [Google Scholar]
  31. Raychowdhury R., Zheng G., Brown D., McCluskey R. T. Induction of Heymann nephritis with a gp330/megalin fusion protein. Am J Pathol. 1996 May;148(5):1613–1623. [PMC free article] [PubMed] [Google Scholar]
  32. Saito A., Pietromonaco S., Loo A. K., Farquhar M. G. Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9725–9729. doi: 10.1073/pnas.91.21.9725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Salant D. J., Quigg R. J., Cybulsky A. V. Heymann nephritis: mechanisms of renal injury. Kidney Int. 1989 Apr;35(4):976–984. doi: 10.1038/ki.1989.81. [DOI] [PubMed] [Google Scholar]
  34. Williams S. E., Ashcom J. D., Argraves W. S., Strickland D. K. A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein. J Biol Chem. 1992 May 5;267(13):9035–9040. [PubMed] [Google Scholar]
  35. Willnow T. E., Goldstein J. L., Orth K., Brown M. S., Herz J. Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. J Biol Chem. 1992 Dec 25;267(36):26172–26180. [PubMed] [Google Scholar]

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