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. 1996 Feb;148(2):355–360.

The Golgi apparatus and the pathogenesis of Alzheimer's disease.

M C Dal Canto 1
PMCID: PMC1861684  PMID: 8579097

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arriagada P. V., Growdon J. H., Hedley-Whyte E. T., Hyman B. T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology. 1992 Mar;42(3 Pt 1):631–639. doi: 10.1212/wnl.42.3.631. [DOI] [PubMed] [Google Scholar]
  2. Busciglio J., Gabuzda D. H., Matsudaira P., Yankner B. A. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2092–2096. doi: 10.1073/pnas.90.5.2092. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Caporaso G. L., Gandy S. E., Buxbaum J. D., Ramabhadran T. V., Greengard P. Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3055–3059. doi: 10.1073/pnas.89.7.3055. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Caporaso G. L., Takei K., Gandy S. E., Matteoli M., Mundigl O., Greengard P., De Camilli P. Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein. J Neurosci. 1994 May;14(5 Pt 2):3122–3138. doi: 10.1523/JNEUROSCI.14-05-03122.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Citron M., Oltersdorf T., Haass C., McConlogue L., Hung A. Y., Seubert P., Vigo-Pelfrey C., Lieberburg I., Selkoe D. J. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 1992 Dec 17;360(6405):672–674. doi: 10.1038/360672a0. [DOI] [PubMed] [Google Scholar]
  6. Citron M., Vigo-Pelfrey C., Teplow D. B., Miller C., Schenk D., Johnston J., Winblad B., Venizelos N., Lannfelt L., Selkoe D. J. Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11993–11997. doi: 10.1073/pnas.91.25.11993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Corder E. H., Saunders A. M., Risch N. J., Strittmatter W. J., Schmechel D. E., Gaskell P. C., Jr, Rimmler J. B., Locke P. A., Conneally P. M., Schmader K. E. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet. 1994 Jun;7(2):180–184. doi: 10.1038/ng0694-180. [DOI] [PubMed] [Google Scholar]
  8. Corder E. H., Saunders A. M., Strittmatter W. J., Schmechel D. E., Gaskell P. C., Small G. W., Roses A. D., Haines J. L., Pericak-Vance M. A. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993 Aug 13;261(5123):921–923. doi: 10.1126/science.8346443. [DOI] [PubMed] [Google Scholar]
  9. Farquhar M. G., Palade G. E. The Golgi apparatus (complex)-(1954-1981)-from artifact to center stage. J Cell Biol. 1981 Dec;91(3 Pt 2):77s–103s. doi: 10.1083/jcb.91.3.77s. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Felsenstein K. M., Ingalls K. M., Hunihan L. W., Roberts S. B. Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate. Neurosci Lett. 1994 Jun 20;174(2):173–176. doi: 10.1016/0304-3940(94)90014-0. [DOI] [PubMed] [Google Scholar]
  11. Glenner G. G., Wong C. W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun. 1984 May 16;120(3):885–890. doi: 10.1016/s0006-291x(84)80190-4. [DOI] [PubMed] [Google Scholar]
  12. Gonatas N. K. Rous-Whipple Award Lecture. Contributions to the physiology and pathology of the Golgi apparatus. Am J Pathol. 1994 Oct;145(4):751–761. [PMC free article] [PubMed] [Google Scholar]
  13. Haass C., Hung A. Y., Schlossmacher M. G., Oltersdorf T., Teplow D. B., Selkoe D. J. Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules. Ann N Y Acad Sci. 1993 Sep 24;695:109–116. doi: 10.1111/j.1749-6632.1993.tb23037.x. [DOI] [PubMed] [Google Scholar]
  14. Haass C., Selkoe D. J. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell. 1993 Dec 17;75(6):1039–1042. doi: 10.1016/0092-8674(93)90312-e. [DOI] [PubMed] [Google Scholar]
  15. Hammerschlag R., Stone G. C., Bolen F. A., Lindsey J. D., Ellisman M. H. Evidence that all newly synthesized proteins destined for fast axonal transport pass through the Golgi apparatus. J Cell Biol. 1982 Jun;93(3):568–575. doi: 10.1083/jcb.93.3.568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Kato T., Sasaki H., Katagiri T., Sasaki H., Koiwai K., Youki H., Totsuka S., Ishii T. The binding of basic fibroblast growth factor to Alzheimer's neurofibrillary tangles and senile plaques. Neurosci Lett. 1991 Jan 14;122(1):33–36. doi: 10.1016/0304-3940(91)90186-w. [DOI] [PubMed] [Google Scholar]
  17. Lucassen P. J., Ravid R., Gonatas N. K., Swaab D. F. Activation of the human supraoptic and paraventricular nucleus neurons with aging and in Alzheimer's disease as judged from increasing size of the Golgi apparatus. Brain Res. 1993 Dec 31;632(1-2):105–113. doi: 10.1016/0006-8993(93)91144-h. [DOI] [PubMed] [Google Scholar]
  18. Matsuo E. S., Shin R. W., Billingsley M. L., Van deVoorde A., O'Connor M., Trojanowski J. Q., Lee V. M. Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron. 1994 Oct;13(4):989–1002. doi: 10.1016/0896-6273(94)90264-x. [DOI] [PubMed] [Google Scholar]
  19. Mourelatos Z., Adler H., Hirano A., Donnenfeld H., Gonatas J. O., Gonatas N. K. Fragmentation of the Golgi apparatus of motor neurons in amyotrophic lateral sclerosis revealed by organelle-specific antibodies. Proc Natl Acad Sci U S A. 1990 Jun;87(11):4393–4395. doi: 10.1073/pnas.87.11.4393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Mourelatos Z., Yachnis A., Rorke L., Mikol J., Gonatas N. K. The Golgi apparatus of motor neurons in amyotrophic lateral sclerosis. Ann Neurol. 1993 Jun;33(6):608–615. doi: 10.1002/ana.410330609. [DOI] [PubMed] [Google Scholar]
  21. Perry G., Siedlak S. L., Richey P., Kawai M., Cras P., Kalaria R. N., Galloway P. G., Scardina J. M., Cordell B., Greenberg B. D. Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease. J Neurosci. 1991 Nov;11(11):3679–3683. doi: 10.1523/JNEUROSCI.11-11-03679.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Salehi A., Lucassen P. J., Pool C. W., Gonatas N. K., Ravid R., Swaab D. F. Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus. Neuroscience. 1994 Apr;59(4):871–880. doi: 10.1016/0306-4522(94)90291-7. [DOI] [PubMed] [Google Scholar]
  23. Salehi A., Ravid R., Gonatas N. K., Swaab D. F. Decreased activity of hippocampal neurons in Alzheimer's disease is not related to the presence of neurofibrillary tangles. J Neuropathol Exp Neurol. 1995 Sep;54(5):704–709. doi: 10.1097/00005072-199509000-00013. [DOI] [PubMed] [Google Scholar]
  24. Saunders A. M., Strittmatter W. J., Schmechel D., George-Hyslop P. H., Pericak-Vance M. A., Joo S. H., Rosi B. L., Gusella J. F., Crapper-MacLachlan D. R., Alberts M. J. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 1993 Aug;43(8):1467–1472. doi: 10.1212/wnl.43.8.1467. [DOI] [PubMed] [Google Scholar]
  25. Selkoe D. J. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu Rev Cell Biol. 1994;10:373–403. doi: 10.1146/annurev.cb.10.110194.002105. [DOI] [PubMed] [Google Scholar]
  26. Seubert P., Vigo-Pelfrey C., Esch F., Lee M., Dovey H., Davis D., Sinha S., Schlossmacher M., Whaley J., Swindlehurst C. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature. 1992 Sep 24;359(6393):325–327. doi: 10.1038/359325a0. [DOI] [PubMed] [Google Scholar]
  27. Shin R. W., Lee V. M., Trojanowski J. Q. Aluminum modifies the properties of Alzheimer's disease PHF tau proteins in vivo and in vitro. J Neurosci. 1994 Nov;14(11 Pt 2):7221–7233. doi: 10.1523/JNEUROSCI.14-11-07221.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Shoji M., Golde T. E., Ghiso J., Cheung T. T., Estus S., Shaffer L. M., Cai X. D., McKay D. M., Tintner R., Frangione B. Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science. 1992 Oct 2;258(5079):126–129. doi: 10.1126/science.1439760. [DOI] [PubMed] [Google Scholar]
  29. Siedlak S. L., Cras P., Kawai M., Richey P., Perry G. Basic fibroblast growth factor binding is a marker for extracellular neurofibrillary tangles in Alzheimer disease. J Histochem Cytochem. 1991 Jul;39(7):899–904. doi: 10.1177/39.7.1865106. [DOI] [PubMed] [Google Scholar]
  30. Stieber A., Mourelatos Z., Gonatas N. K. In Alzheimer's disease the Golgi apparatus of a population of neurons without neurofibrillary tangles is fragmented and atrophic. Am J Pathol. 1996 Feb;148(2):415–426. [PMC free article] [PubMed] [Google Scholar]
  31. Strittmatter W. J., Saunders A. M., Schmechel D., Pericak-Vance M., Enghild J., Salvesen G. S., Roses A. D. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977–1981. doi: 10.1073/pnas.90.5.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Strittmatter W. J., Weisgraber K. H., Goedert M., Saunders A. M., Huang D., Corder E. H., Dong L. M., Jakes R., Alberts M. J., Gilbert J. R. Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp Neurol. 1994 Feb;125(2):163–174. doi: 10.1006/exnr.1994.1019. [DOI] [PubMed] [Google Scholar]
  33. Terry R. D., Masliah E., Salmon D. P., Butters N., DeTeresa R., Hill R., Hansen L. A., Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol. 1991 Oct;30(4):572–580. doi: 10.1002/ana.410300410. [DOI] [PubMed] [Google Scholar]
  34. Trojanowski J. Q., Lee V. M. Phosphorylation of neuronal cytoskeletal proteins in Alzheimer's disease and Lewy body dementias. Ann N Y Acad Sci. 1994 Dec 15;747:92–109. doi: 10.1111/j.1749-6632.1994.tb44403.x. [DOI] [PubMed] [Google Scholar]
  35. Trojanowski J. Q., Schmidt M. L., Shin R. W., Bramblett G. T., Rao D., Lee V. M. Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias. Brain Pathol. 1993 Jan;3(1):45–54. doi: 10.1111/j.1750-3639.1993.tb00725.x. [DOI] [PubMed] [Google Scholar]
  36. Wisniewski T., Frangione B. Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett. 1992 Feb 3;135(2):235–238. doi: 10.1016/0304-3940(92)90444-c. [DOI] [PubMed] [Google Scholar]
  37. Wisniewski T., Ghiso J., Frangione B. Alzheimer's disease and soluble A beta. Neurobiol Aging. 1994 Mar-Apr;15(2):143–152. doi: 10.1016/0197-4580(94)90105-8. [DOI] [PubMed] [Google Scholar]
  38. Xu H., Greengard P., Gandy S. Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein. J Biol Chem. 1995 Oct 6;270(40):23243–23245. doi: 10.1074/jbc.270.40.23243. [DOI] [PubMed] [Google Scholar]

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