Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1994 Feb;62(2):733–737. doi: 10.1128/iai.62.2.733-737.1994

Immunization against experimental coccidiosis produces contrasting results in inbred mice of differing susceptibility to infection.

M E Rose 1, P Hesketh 1, D Wakelin 1
PMCID: PMC186169  PMID: 8300235

Abstract

Pretreatment of inbred mice with intravenous and/or intraperitoneal injection of an antigen prepared from sporozoites of Eimeria vermiformis modulated the course of infection with the parasite in a manner that depended on the resistance-susceptibility phenotype of the host. Mice with a resistant background (BALB) produced more oocysts and those with a susceptible background (C57BL) produced fewer oocysts than their respective controls. The optimum conditions for producing these effects were established, and evidence is presented which suggests that the phenomenon might also apply in the target host, the chicken.

Full text

PDF
736

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bumstead N., Millard B. Genetics of resistance to coccidiosis: response of inbred chicken lines to infection by Eimeria tenella and Eimeria maxima. Br Poult Sci. 1987 Dec;28(4):705–715. doi: 10.1080/00071668708417006. [DOI] [PubMed] [Google Scholar]
  2. Doherty T. M., Coffman R. L. Leishmania antigens presented by GM-CSF-derived macrophages protect susceptible mice against challenge with Leishmania major. J Immunol. 1993 Jun 15;150(12):5476–5483. [PubMed] [Google Scholar]
  3. Joysey H. S., Wakelin D., Rose M. E. Resistance to infection with Eimeria vermiformis in mouse radiation chimeras is determined by donor bone-marrow cells. Infect Immun. 1988 May;56(5):1399–1401. doi: 10.1128/iai.56.5.1399-1401.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Klesius P. H., Hinds S. E. Strain-dependent differences in murine susceptibility to coccidia. Infect Immun. 1979 Dec;26(3):1111–1115. doi: 10.1128/iai.26.3.1111-1115.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kramer J. D., Bogitsh B. J. Schistosoma japonicum: biochemistry and cytochemistry of dipeptidyl aminopeptidase-II-like activity in adults. Exp Parasitol. 1985 Oct;60(2):163–170. doi: 10.1016/0014-4894(85)90019-0. [DOI] [PubMed] [Google Scholar]
  6. Liew F. Y. Functional heterogeneity of CD4+ T cells in leishmaniasis. Immunol Today. 1989 Feb;10(2):40–45. doi: 10.1016/0167-5699(89)90302-2. [DOI] [PubMed] [Google Scholar]
  7. Liew F. Y., Hale C., Howard J. G. Prophylactic immunization against experimental leishmaniasis. IV. Subcutaneous immunization prevents the induction of protective immunity against fatal Leishmania major infection. J Immunol. 1985 Sep;135(3):2095–2101. [PubMed] [Google Scholar]
  8. Lillehoj H. S., Jenkins M. C., Bacon L. D. Effects of major histocompatibility genes and antigen delivery on induction of protective mucosal immunity to E. acervulina following immunization with a recombinant merozoite antigen. Immunology. 1990 Sep;71(1):127–132. [PMC free article] [PubMed] [Google Scholar]
  9. Lillehoj H. S., Jenkins M. C., Bacon L. D., Fetterer R. H., Briles W. E. Eimeria acervulina: evaluation of the cellular and antibody responses to the recombinant coccidial antigens in B-congenic chickens. Exp Parasitol. 1988 Dec;67(2):148–158. doi: 10.1016/0014-4894(88)90062-8. [DOI] [PubMed] [Google Scholar]
  10. Long P. L., Millard B. J., Joyner L. P., Norton C. C. A guide to laboratory techniques used in the study and diagnosis of avian coccidiosis. Folia Vet Lat. 1976 Jul-Sep;6(3):201–217. [PubMed] [Google Scholar]
  11. Mahrt J. L., Shi Y. F. Murine major histocompatibility complex and immune response to Eimeria falciformis. Infect Immun. 1988 Jan;56(1):270–271. doi: 10.1128/iai.56.1.270-271.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rose M. E. Eimeria tenella: skin hypersensitivity to injected antigen in the fowl. Exp Parasitol. 1977 Jun;42(1):129–141. doi: 10.1016/0014-4894(77)90070-4. [DOI] [PubMed] [Google Scholar]
  13. Rose M. E., Hesketh P. Eimeria tenella: effects of immunity on sporozoites within the lumen of the small intestine. Exp Parasitol. 1987 Jun;63(3):337–344. doi: 10.1016/0014-4894(87)90181-0. [DOI] [PubMed] [Google Scholar]
  14. Rose M. E., Owen D. G., Hesketh P. Susceptibility to coccidiosis: effect of strain of mouse on reproduction of Eimeria vermiformis. Parasitology. 1984 Feb;88(Pt 1):45–54. doi: 10.1017/s0031182000054330. [DOI] [PubMed] [Google Scholar]
  15. Rose M. E., Smith A. L., Wakelin D. Gamma interferon-mediated inhibition of Eimeria vermiformis growth in cultured fibroblasts and epithelial cells. Infect Immun. 1991 Feb;59(2):580–586. doi: 10.1128/iai.59.2.580-586.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rose M. E., Wakelin D., Hesketh P. Eimeria vermiformis: differences in the course of primary infection can be correlated with lymphocyte responsiveness in the BALB/c and C57BL/6 mouse, Mus musculus. Exp Parasitol. 1990 Oct;71(3):276–283. doi: 10.1016/0014-4894(90)90032-8. [DOI] [PubMed] [Google Scholar]
  17. Rose M. E., Wakelin D., Joysey H. S., Hesketh P. Immunity to coccidiosis: adoptive transfer in NIH mice challenged with Eimeria vermiformis. Parasite Immunol. 1988 Jan;10(1):59–69. doi: 10.1111/j.1365-3024.1988.tb00203.x. [DOI] [PubMed] [Google Scholar]
  18. Scott P. The role of TH1 and TH2 cells in experimental cutaneous leishmaniasis. Exp Parasitol. 1989 Apr;68(3):369–372. doi: 10.1016/0014-4894(89)90120-3. [DOI] [PubMed] [Google Scholar]
  19. Stockdale P. G., Stockdale M. J., Rickard M. D., Mitchell G. F. Mouse strain variation and effects of oocyst dose in infection of mice with Eimeria falciformis, a coccidian parasite of the large intestine. Int J Parasitol. 1985 Aug;15(4):447–452. doi: 10.1016/0020-7519(85)90032-3. [DOI] [PubMed] [Google Scholar]
  20. Wakelin D., Mitchell L. A., Donachie A. M., Grencis R. K. Genetic control of immunity to Trichinella spiralis in mice. Response of rapid- and slow-responder strains to immunization with parasite antigens. Parasite Immunol. 1986 Mar;8(2):159–170. doi: 10.1111/j.1365-3024.1986.tb00842.x. [DOI] [PubMed] [Google Scholar]
  21. Wakelin D., Rose M. E., Hesketh P., Else K. J., Grencis R. K. Immunity to coccidiosis: genetic influences on lymphocyte and cytokine responses to infection with Eimeria vermiformis in inbred mice. Parasite Immunol. 1993 Jan;15(1):11–19. doi: 10.1111/j.1365-3024.1993.tb00567.x. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES