Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1994 Feb;62(2):747–750. doi: 10.1128/iai.62.2.747-750.1994

Conconavalin A-stimulated bovine T-cell supernatants inhibit growth of Cowdria ruminantium in bovine endothelial cells in vitro.

S M Mahan 1, G E Smith 1, B Byrom 1
PMCID: PMC186172  PMID: 8300237

Abstract

Conconavalin A-stimulated bovine T-cell supernatants inhibited the growth of Cowdria ruminantium in bovine endothelial cells in vitro but did not affect their entry. This finding represents one mechanism by which T cells may control C. ruminantium multiplication and hence affect the severity of disease.

Full text

PDF
748

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Byrom B., Yunker C. E. Improved culture conditions for Cowdria ruminantium (Rickettsiales), the agent of heartwater disease of domestic ruminants. Cytotechnology. 1990 Nov;4(3):285–290. doi: 10.1007/BF00563789. [DOI] [PubMed] [Google Scholar]
  2. Carl M., Dasch G. A. Characterization of human cytotoxic lymphocytes directed against cells infected with typhus group rickettsiae: evidence for lymphokine activation of effectors. J Immunol. 1986 Apr 1;136(7):2654–2661. [PubMed] [Google Scholar]
  3. Carl M., Robbins F. M., Hartzman R. J., Dasch G. A. Lysis of cells infected with typhus group rickettsiae by a human cytotoxic T cell clone. J Immunol. 1987 Dec 15;139(12):4203–4207. [PubMed] [Google Scholar]
  4. Cerretti D. P., McKereghan K., Larsen A., Cosman D., Gillis S., Baker P. E. Cloning, sequence, and expression of bovine interferon-gamma. J Immunol. 1986 Jun 15;136(12):4561–4564. [PubMed] [Google Scholar]
  5. Hanson B. Susceptibility of Rickettsia tsutsugamushi Gilliam to gamma interferon in cultured mouse cells. Infect Immun. 1991 Nov;59(11):4125–4133. doi: 10.1128/iai.59.11.4125-4133.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Li H., Jerrells T. R., Spitalny G. L., Walker D. H. Gamma interferon as a crucial host defense against Rickettsia conorii in vivo. Infect Immun. 1987 May;55(5):1252–1255. doi: 10.1128/iai.55.5.1252-1255.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MacMillan J. G., Rice R. M., Jerrells T. R. Development of antigen-specific cell-mediated immune responses after infection of cynomolgus monkeys (Macaca fascicularis) with Rickettsia tsutsugamushi. J Infect Dis. 1985 Oct;152(4):739–749. doi: 10.1093/infdis/152.4.739. [DOI] [PubMed] [Google Scholar]
  8. Mebus C. A., Logan L. L. Heartwater disease of domestic and wild ruminants. J Am Vet Med Assoc. 1988 Apr 1;192(7):950–952. [PubMed] [Google Scholar]
  9. Nacy C. A., Leonard E. J., Meltzer M. S. Macrophages in resistance to rickettsial infections: characterization of lymphokines that induce rickettsiacidal activity in macrophages. J Immunol. 1981 Jan;126(1):204–207. [PubMed] [Google Scholar]
  10. Palmer B. A., Hetrick F. M., Jerrells T. R. Gamma interferon production in response to homologous and heterologous strain antigens in mice chronically infected with Rickettsia tsutsugamushi. Infect Immun. 1984 Oct;46(1):237–244. doi: 10.1128/iai.46.1.237-244.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Patarca R., Freeman G. J., Singh R. P., Wei F. Y., Durfee T., Blattner F., Regnier D. C., Kozak C. A., Mock B. A., Morse H. C., 3rd Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection. J Exp Med. 1989 Jul 1;170(1):145–161. doi: 10.1084/jem.170.1.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Peter J. B., Stratton J. A., Stempel K. E., Yu D., Cardin C. Characteristics of a cytotoxin ("lymphotoxin") produced by stimulation of human lymphoid tissue. J Immunol. 1973 Sep;111(3):770–782. [PubMed] [Google Scholar]
  13. Turco J., Keysary A., Winkler H. H. Interferon-gamma- and rickettsia-induced killing of macrophage-like cells is inhibited by anti-rickettsial antibodies and does not require the respiratory burst. J Interferon Res. 1989 Oct;9(5):615–629. doi: 10.1089/jir.1989.9.615. [DOI] [PubMed] [Google Scholar]
  14. Turco J., Winkler H. H. Cloned mouse interferon-gamma inhibits the growth of Rickettsia prowazekii in cultured mouse fibroblasts. J Exp Med. 1983 Dec 1;158(6):2159–2164. doi: 10.1084/jem.158.6.2159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Turco J., Winkler H. H. Effect of mouse lymphokines and cloned mouse interferon-gamma on the interaction of Rickettsia prowazekii with mouse macrophage-like RAW264.7 cells. Infect Immun. 1984 Aug;45(2):303–308. doi: 10.1128/iai.45.2.303-308.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Turco J., Winkler H. H. Inhibition of the growth of Rickettsia prowazekii in cultured fibroblasts by lymphokines. J Exp Med. 1983 Mar 1;157(3):974–986. doi: 10.1084/jem.157.3.974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Uilenberg G. Heartwater (Cowdria ruminantium infection): current status. Adv Vet Sci Comp Med. 1983;27:427–480. [PubMed] [Google Scholar]
  18. Wisseman C. L., Jr, Waddell A. Interferonlike factors from antigen- and mitogen-stimulated human leukocytes with antirickettsial and cytolytic actions on Rickettsia prowazekii. Infected human endothelial cells, fibroblasts, and macrophages. J Exp Med. 1983 Jun 1;157(6):1780–1793. doi: 10.1084/jem.157.6.1780. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES