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. 1994 Jun;62(6):2165–2168. doi: 10.1128/iai.62.6.2165-2168.1994

Pioneer oral streptococci produce immunoglobulin A1 protease.

M F Cole 1, M Evans 1, S Fitzsimmons 1, J Johnson 1, C Pearce 1, M J Sheridan 1, R Wientzen 1, G Bowden 1
PMCID: PMC186493  PMID: 8188337

Abstract

As part of a longitudinal study of the relationship between bacterial colonization and the secretory immune response, 367 isolates of pioneer viridans streptococci collected from 40 breast- and bottle-fed neonates within the first month postpartum were tested for the production of immunoglobulin A1 (IgA1) protease and glycosidases. Fifty percent of the streptococci isolated produced IgA1 protease, including all isolates of Streptococcus oralis and S. sanguis, 60.7% of S. mitis biovar 1 isolates, and some isolates that could not be identified. Three cleavage patterns of alpha 1 heavy chains were observed. Six isolates of S. mitis biovar 1 that did not produce IgA1 protease attacked the alpha 1 chain. Incubation of IgA1 protease-negative S. mitis biovar 1 isolates with IgA1, either prior to or together with S. sanguis, rendered the IgA1 paraprotein resistant to cleavage by the IgA1 protease of S. sanguis. The ability of some pioneer streptococci in the human oral cavity to produce IgA1 protease and of others to modify the susceptibility of IgA1 to cleavage by IgA1 protease perhaps enhances their ability to survive in this habitat.

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Selected References

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  1. Beighton D., Hardie J. M., Whiley R. A. A scheme for the identification of viridans streptococci. J Med Microbiol. 1991 Dec;35(6):367–372. doi: 10.1099/00222615-35-6-367. [DOI] [PubMed] [Google Scholar]
  2. Cole M. F., Hale C. A. Cleavage of chimpanzee secretory immunoglobulin A by Haemophilus influenzae IgA1 protease. Microb Pathog. 1991 Jul;11(1):39–46. doi: 10.1016/0882-4010(91)90092-o. [DOI] [PubMed] [Google Scholar]
  3. Delacroix D. L., Dive C., Rambaud J. C., Vaerman J. P. IgA subclasses in various secretions and in serum. Immunology. 1982 Oct;47(2):383–385. [PMC free article] [PubMed] [Google Scholar]
  4. Fitzsimmons S. P., Evans M. K., Pearce C. L., Sheridan M. J., Wientzen R., Cole M. F. Immunoglobulin A subclasses in infants' saliva and in saliva and milk from their mothers. J Pediatr. 1994 Apr;124(4):566–573. doi: 10.1016/s0022-3476(05)83135-x. [DOI] [PubMed] [Google Scholar]
  5. Frandsen E. V., Pedrazzoli V., Kilian M. Ecology of viridans streptococci in the oral cavity and pharynx. Oral Microbiol Immunol. 1991 Jun;6(3):129–133. doi: 10.1111/j.1399-302x.1991.tb00466.x. [DOI] [PubMed] [Google Scholar]
  6. Gibbons R. J., Hay D. I., Childs W. C., 3rd, Davis G. Role of cryptic receptors (cryptitopes) in bacterial adhesion to oral surfaces. Arch Oral Biol. 1990;35 (Suppl):107S–114S. doi: 10.1016/0003-9969(90)90139-2. [DOI] [PubMed] [Google Scholar]
  7. Hsu S. D., Cole M. F. Structural integrity of host defense factors in dental plaque. Infect Immun. 1985 Nov;50(2):398–402. doi: 10.1128/iai.50.2.398-402.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kilian M., Holmgren K. Ecology and nature of immunoglobulin A1 protease-producing streptococci in the human oral cavity and pharynx. Infect Immun. 1981 Mar;31(3):868–873. doi: 10.1128/iai.31.3.868-873.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kilian M., Mestecky J., Russell M. W. Defense mechanisms involving Fc-dependent functions of immunoglobulin A and their subversion by bacterial immunoglobulin A proteases. Microbiol Rev. 1988 Jun;52(2):296–303. doi: 10.1128/mr.52.2.296-303.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kilian M., Reinholdt J. A hypothetical model for the development of invasive infection due to IgA1 protease-producing bacteria. Adv Exp Med Biol. 1987;216B:1261–1269. [PubMed] [Google Scholar]
  11. Kilian M., Reinholdt J., Nyvad B., Frandsen E. V., Mikkelsen L. IgA1 proteases of oral streptococci: ecological aspects. Immunol Invest. 1989 Jan-May;18(1-4):161–170. doi: 10.3109/08820138909112235. [DOI] [PubMed] [Google Scholar]
  12. Reinholdt J., Friman V., Kilian M. Similar proportions of immunoglobulin A1 (IgA1) protease-producing streptococci in initial dental plaque of selectively IgA-deficient and normal individuals. Infect Immun. 1993 Sep;61(9):3998–4000. doi: 10.1128/iai.61.9.3998-4000.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Reinholdt J., Kilian M. Interference of IgA protease with the effect of secretory IgA on adherence of oral streptococci to saliva-coated hydroxyapatite. J Dent Res. 1987 Feb;66(2):492–497. doi: 10.1177/00220345870660021801. [DOI] [PubMed] [Google Scholar]
  14. Reinholdt J., Tomana M., Mortensen S. B., Kilian M. Molecular aspects of immunoglobulin A1 degradation by oral streptococci. Infect Immun. 1990 May;58(5):1186–1194. doi: 10.1128/iai.58.5.1186-1194.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Smith D. J., Anderson J. M., King W. F., van Houte J., Taubman M. A. Oral streptococcal colonization of infants. Oral Microbiol Immunol. 1993 Feb;8(1):1–4. doi: 10.1111/j.1399-302x.1993.tb00535.x. [DOI] [PubMed] [Google Scholar]
  16. Smith D. J., Taubman M. A., Ebersole J. L. Ontogeny and senescence of salivary immunity. J Dent Res. 1987 Feb;66(2):451–456. doi: 10.1177/00220345870660021101. [DOI] [PubMed] [Google Scholar]
  17. Syed S. A., Loesche W. J. Survival of human dental plaque flora in various transport media. Appl Microbiol. 1972 Oct;24(4):638–644. doi: 10.1128/am.24.4.638-644.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Whiley R. A., Fraser H., Hardie J. M., Beighton D. Phenotypic differentiation of Streptococcus intermedius, Streptococcus constellatus, and Streptococcus anginosus strains within the "Streptococcus milleri group". J Clin Microbiol. 1990 Jul;28(7):1497–1501. doi: 10.1128/jcm.28.7.1497-1501.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]

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