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. 1974 Jul;28(1):52–57. doi: 10.1128/am.28.1.52-57.1974

Step of Dichlorvos Inhibition in the Pathway of Aflatoxin Biosynthesis

Raymond C Yao 1, Dennis P H Hsieh 1
PMCID: PMC186587  PMID: 4844267

Abstract

Dichlorvos (dimethyl 2,2-dichlorovinyl phosphate) inhibits the biosynthesis of aflatoxin by Aspergillus parasiticus. Cultures treated with dichlorvos excrete an orange pigment which can be converted into aflatoxin B1 by the untreated mycelia. The orange pigment was partially identified as an acetyl derivative of versiconol-type compound. In the presence of dichlorvos, sterigmatocystin is converted into aflatoxin B1 without being interfered, but averufin is converted into the orange pigment instead of aflatoxin B1. Therefore, dichlorvos appears to block an enzymatic step in the aflatoxin biosynthetic pathway, which lies beyond averufin but before sterigmatocystin, at the formation of the orange pigment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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