Abstract
"Blood vessels have the power to increase within themselves which is according to the necessity whether natural or diseased. As a further proof that this is a general principle, we find that all growing parts are much more vascular than those that are come to their full growth; because growth is an operation beyond the simple support of the part. This is the reason why young animals are more vascular than those that are full grown. This is not peculiar to the natural operation of growth, but applies also to disease and restoration."
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- Abraham J. A., Mergia A., Whang J. L., Tumolo A., Friedman J., Hjerrild K. A., Gospodarowicz D., Fiddes J. C. Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor. Science. 1986 Aug 1;233(4763):545–548. doi: 10.1126/science.2425435. [DOI] [PubMed] [Google Scholar]
- Alvarez J. A., Baird A., Tatum A., Daucher J., Chorsky R., Gonzalez A. M., Stopa E. G. Localization of basic fibroblast growth factor and vascular endothelial growth factor in human glial neoplasms. Mod Pathol. 1992 May;5(3):303–307. [PubMed] [Google Scholar]
- Antonelli-Orlidge A., Saunders K. B., Smith S. R., D'Amore P. A. An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4544–4548. doi: 10.1073/pnas.86.12.4544. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Arita N., Hayakawa T., Izumoto S., Taki T., Ohnishi T., Yamamoto H., Bitoh S., Mogami H. Epidermal growth factor receptor in human glioma. J Neurosurg. 1989 Jun;70(6):916–919. doi: 10.3171/jns.1989.70.6.0916. [DOI] [PubMed] [Google Scholar]
- Ausprunk D. H., Folkman J. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res. 1977 Jul;14(1):53–65. doi: 10.1016/0026-2862(77)90141-8. [DOI] [PubMed] [Google Scholar]
- Badet J., Soncin F., Guitton J. D., Lamare O., Cartwright T., Barritault D. Specific binding of angiogenin to calf pulmonary artery endothelial cells. Proc Natl Acad Sci U S A. 1989 Nov;86(21):8427–8431. doi: 10.1073/pnas.86.21.8427. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Baird A., Durkin T. Inhibition of endothelial cell proliferation by type beta-transforming growth factor: interactions with acidic and basic fibroblast growth factors. Biochem Biophys Res Commun. 1986 Jul 16;138(1):476–482. doi: 10.1016/0006-291x(86)90305-0. [DOI] [PubMed] [Google Scholar]
- Barrett T. B., Gajdusek C. M., Schwartz S. M., McDougall J. K., Benditt E. P. Expression of the sis gene by endothelial cells in culture and in vivo. Proc Natl Acad Sci U S A. 1984 Nov;81(21):6772–6774. doi: 10.1073/pnas.81.21.6772. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Basilico C., Moscatelli D. The FGF family of growth factors and oncogenes. Adv Cancer Res. 1992;59:115–165. doi: 10.1016/s0065-230x(08)60305-x. [DOI] [PubMed] [Google Scholar]
- Battegay E. J., Rupp J., Iruela-Arispe L., Sage E. H., Pech M. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors. J Cell Biol. 1994 May;125(4):917–928. doi: 10.1083/jcb.125.4.917. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Beitz J. G., Kim I. S., Calabresi P., Frackelton A. R., Jr Human microvascular endothelial cells express receptors for platelet-derived growth factor. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):2021–2025. doi: 10.1073/pnas.88.5.2021. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Berkman R. A., Merrill M. J., Reinhold W. C., Monacci W. T., Saxena A., Clark W. C., Robertson J. T., Ali I. U., Oldfield E. H. Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. J Clin Invest. 1993 Jan;91(1):153–159. doi: 10.1172/JCI116165. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bigner S. H., Burger P. C., Wong A. J., Werner M. H., Hamilton S. R., Muhlbaier L. H., Vogelstein B., Bigner D. D. Gene amplification in malignant human gliomas: clinical and histopathologic aspects. J Neuropathol Exp Neurol. 1988 May;47(3):191–205. doi: 10.1097/00005072-198805000-00001. [DOI] [PubMed] [Google Scholar]
- Bigner S. H., Vogelstein B. Cytogenetics and molecular genetics of malignant gliomas and medulloblastoma. Brain Pathol. 1990 Sep;1(1):12–18. doi: 10.1111/j.1750-3639.1990.tb00633.x. [DOI] [PubMed] [Google Scholar]
- Bodmer S., Huber D., Heid I., Fontana A. Human glioblastoma cell derived transforming growth factor-beta 2: evidence for secretion of both high and low molecular weight biologically active forms. J Neuroimmunol. 1991 Oct;34(1):33–42. doi: 10.1016/0165-5728(91)90096-p. [DOI] [PubMed] [Google Scholar]
- Bodmer S., Strommer K., Frei K., Siepl C., de Tribolet N., Heid I., Fontana A. Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2. J Immunol. 1989 Nov 15;143(10):3222–3229. [PubMed] [Google Scholar]
- Bonthron D. T., Sultan P., Collins T. Structure of the murine c-sis proto-oncogene (Sis, PDGFB) encoding the B chain of platelet-derived growth factor. Genomics. 1991 May;10(1):287–292. doi: 10.1016/0888-7543(91)90515-g. [DOI] [PubMed] [Google Scholar]
- Breier G., Albrecht U., Sterrer S., Risau W. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development. 1992 Feb;114(2):521–532. doi: 10.1242/dev.114.2.521. [DOI] [PubMed] [Google Scholar]
- Brem S. S., Zagzag D., Tsanaclis A. M., Gately S., Elkouby M. P., Brien S. E. Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor. Am J Pathol. 1990 Nov;137(5):1121–1142. [PMC free article] [PubMed] [Google Scholar]
- Brem S., Cotran R., Folkman J. Tumor angiogenesis: a quantitative method for histologic grading. J Natl Cancer Inst. 1972 Feb;48(2):347–356. [PubMed] [Google Scholar]
- Brem S. The role of vascular proliferation in the growth of brain tumors. Clin Neurosurg. 1976;23:440–453. doi: 10.1093/neurosurgery/23.cn_suppl_1.440. [DOI] [PubMed] [Google Scholar]
- Brem S., Tsanaclis A. M., Gately S., Gross J. L., Herblin W. F. Immunolocalization of basic fibroblast growth factor to the microvasculature of human brain tumors. Cancer. 1992 Dec 1;70(11):2673–2680. doi: 10.1002/1097-0142(19921201)70:11<2673::aid-cncr2820701118>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
- Brooks P. C., Clark R. A., Cheresh D. A. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science. 1994 Apr 22;264(5158):569–571. doi: 10.1126/science.7512751. [DOI] [PubMed] [Google Scholar]
- Burger P. C., Vogel F. S., Green S. B., Strike T. A. Glioblastoma multiforme and anaplastic astrocytoma. Pathologic criteria and prognostic implications. Cancer. 1985 Sep 1;56(5):1106–1111. doi: 10.1002/1097-0142(19850901)56:5<1106::aid-cncr2820560525>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
- Burgess A. W. Epidermal growth factor and transforming growth factor alpha. Br Med Bull. 1989 Apr;45(2):401–424. doi: 10.1093/oxfordjournals.bmb.a072331. [DOI] [PubMed] [Google Scholar]
- Caday C. G., Klagsbrun M., Fanning P. J., Mirzabegian A., Finklestein S. P. Fibroblast growth factor (FGF) levels in the developing rat brain. Brain Res Dev Brain Res. 1990 Mar 1;52(1-2):241–246. doi: 10.1016/0165-3806(90)90240-y. [DOI] [PubMed] [Google Scholar]
- Carpenter G. Epidermal growth factor: biology and receptor metabolism. J Cell Sci Suppl. 1985;3:1–9. doi: 10.1242/jcs.1985.supplement_3.1. [DOI] [PubMed] [Google Scholar]
- Chailleux E., Dabouis G., Pioche D., de Lajartre M., de Lajartre A. Y., Rembeaux A., Germaud P. Prognostic factors in diffuse malignant pleural mesothelioma. A study of 167 patients. Chest. 1988 Jan;93(1):159–162. doi: 10.1378/chest.93.1.159. [DOI] [PubMed] [Google Scholar]
- Challa V. R., Moody D. M., Marshall R. B., Kelly D. L., Jr The vascular component in meningiomas associated with severe cerebral edema. Neurosurgery. 1980 Oct;7(4):363–368. doi: 10.1227/00006123-198010000-00009. [DOI] [PubMed] [Google Scholar]
- Clark W. C., Bressler J. Transforming growth factor-beta-like activity in tumors of the central nervous system. J Neurosurg. 1988 Jun;68(6):920–924. doi: 10.3171/jns.1988.68.6.0920. [DOI] [PubMed] [Google Scholar]
- Conn G., Bayne M. L., Soderman D. D., Kwok P. W., Sullivan K. A., Palisi T. M., Hope D. A., Thomas K. A. Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2628–2632. doi: 10.1073/pnas.87.7.2628. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Conn G., Soderman D. D., Schaeffer M. T., Wile M., Hatcher V. B., Thomas K. A. Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1323–1327. doi: 10.1073/pnas.87.4.1323. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Connolly D. T., Heuvelman D. M., Nelson R., Olander J. V., Eppley B. L., Delfino J. J., Siegel N. R., Leimgruber R. M., Feder J. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest. 1989 Nov;84(5):1470–1478. doi: 10.1172/JCI114322. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Connolly D. T., Olander J. V., Heuvelman D., Nelson R., Monsell R., Siegel N., Haymore B. L., Leimgruber R., Feder J. Human vascular permeability factor. Isolation from U937 cells. J Biol Chem. 1989 Nov 25;264(33):20017–20024. [PubMed] [Google Scholar]
- D'Amore P. A., Thompson R. W. Mechanisms of angiogenesis. Annu Rev Physiol. 1987;49:453–464. doi: 10.1146/annurev.ph.49.030187.002321. [DOI] [PubMed] [Google Scholar]
- DRAKE C. G., McGEE D. Apoplexy associated with brain tumours. Can Med Assoc J. 1961 Feb 11;84:303–305. [PMC free article] [PubMed] [Google Scholar]
- Daumas-Duport C., Scheithauer B., O'Fallon J., Kelly P. Grading of astrocytomas. A simple and reproducible method. Cancer. 1988 Nov 15;62(10):2152–2165. doi: 10.1002/1097-0142(19881115)62:10<2152::aid-cncr2820621015>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
- DeClerck Y. A., Laug W. E. Inhibition of tumor cell collagenolytic activity by bovine endothelial cells. Cancer Res. 1986 Jul;46(7):3580–3586. [PubMed] [Google Scholar]
- Deane B. R., Lantos P. L. The vasculature of experimental brain tumours. Part 1. A sequential light and electron microscope study of angiogenesis. J Neurol Sci. 1981 Jan;49(1):55–66. doi: 10.1016/0022-510x(81)90188-x. [DOI] [PubMed] [Google Scholar]
- Del Maestro R. F., Megyesi J. F., Farrell C. L. Mechanisms of tumor-associated edema: a review. Can J Neurol Sci. 1990 May;17(2):177–183. doi: 10.1017/s0317167100030419. [DOI] [PubMed] [Google Scholar]
- DiCorleto P. E., Bowen-Pope D. F. Cultured endothelial cells produce a platelet-derived growth factor-like protein. Proc Natl Acad Sci U S A. 1983 Apr;80(7):1919–1923. doi: 10.1073/pnas.80.7.1919. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eccleston P. A., Gunton D. J., Silberberg D. H. Requirements for brain cell attachment, survival and growth in serum-free medium: effects of extracellular matrix, epidermal growth factor and fibroblast growth factor. Dev Neurosci. 1985;7(5-6):308–322. doi: 10.1159/000112299. [DOI] [PubMed] [Google Scholar]
- Eccleston P. A., Silberberg D. H. Fibroblast growth factor is a mitogen for oligodendrocytes in vitro. Brain Res. 1985 Aug;353(2):315–318. doi: 10.1016/0165-3806(85)90221-4. [DOI] [PubMed] [Google Scholar]
- Ekstrand A. J., James C. D., Cavenee W. K., Seliger B., Pettersson R. F., Collins V. P. Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res. 1991 Apr 15;51(8):2164–2172. [PubMed] [Google Scholar]
- FEIGIN I., ALLEN L. B., LIPKIN L., GROSS S. W. The endothelial hyperplasia of the cerebral blood vessels with brain tumors, and its sarcomatous transformation. Cancer. 1958 Mar-Apr;11(2):264–277. doi: 10.1002/1097-0142(195803/04)11:2<264::aid-cncr2820110207>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
- Fallon J. H., Seroogy K. B., Loughlin S. E., Morrison R. S., Bradshaw R. A., Knaver D. J., Cunningham D. D. Epidermal growth factor immunoreactive material in the central nervous system: location and development. Science. 1984 Jun 8;224(4653):1107–1109. doi: 10.1126/science.6144184. [DOI] [PubMed] [Google Scholar]
- Ferrara N., Henzel W. J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun. 1989 Jun 15;161(2):851–858. doi: 10.1016/0006-291x(89)92678-8. [DOI] [PubMed] [Google Scholar]
- Ferrara N., Houck K. A., Jakeman L. B., Winer J., Leung D. W. The vascular endothelial growth factor family of polypeptides. J Cell Biochem. 1991 Nov;47(3):211–218. doi: 10.1002/jcb.240470305. [DOI] [PubMed] [Google Scholar]
- Ferrara N., Houck K., Jakeman L., Leung D. W. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev. 1992 Feb;13(1):18–32. doi: 10.1210/edrv-13-1-18. [DOI] [PubMed] [Google Scholar]
- Finkelstein S. D., Black P., Nowak T. P., Hand C. M., Christensen S., Finch P. W. Histological characteristics and expression of acidic and basic fibroblast growth factor genes in intracerebral xenogeneic transplants of human glioma cells. Neurosurgery. 1994 Jan;34(1):136–143. [PubMed] [Google Scholar]
- Finklestein S. P., Apostolides P. J., Caday C. G., Prosser J., Philips M. F., Klagsbrun M. Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds. Brain Res. 1988 Sep 20;460(2):253–259. doi: 10.1016/0006-8993(88)90370-8. [DOI] [PubMed] [Google Scholar]
- Flamme I., Risau W. Induction of vasculogenesis and hematopoiesis in vitro. Development. 1992 Oct;116(2):435–439. doi: 10.1242/dev.116.2.435. [DOI] [PubMed] [Google Scholar]
- Flanders K. C., Lüdecke G., Engels S., Cissel D. S., Roberts A. B., Kondaiah P., Lafyatis R., Sporn M. B., Unsicker K. Localization and actions of transforming growth factor-beta s in the embryonic nervous system. Development. 1991 Sep;113(1):183–191. doi: 10.1242/dev.113.1.183. [DOI] [PubMed] [Google Scholar]
- Flaumenhaft R., Abe M., Mignatti P., Rifkin D. B. Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity. J Cell Biol. 1992 Aug;118(4):901–909. doi: 10.1083/jcb.118.4.901. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Florkiewicz R. Z., Sommer A. Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons. Proc Natl Acad Sci U S A. 1989 Jun;86(11):3978–3981. doi: 10.1073/pnas.86.11.3978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Folkman J., Klagsbrun M. Angiogenic factors. Science. 1987 Jan 23;235(4787):442–447. doi: 10.1126/science.2432664. [DOI] [PubMed] [Google Scholar]
- Fràter-Schröder M., Müller G., Birchmeier W., Böhlen P. Transforming growth factor-beta inhibits endothelial cell proliferation. Biochem Biophys Res Commun. 1986 May 29;137(1):295–302. doi: 10.1016/0006-291x(86)91209-x. [DOI] [PubMed] [Google Scholar]
- Fràter-Schröder M., Risau W., Hallmann R., Gautschi P., Böhlen P. Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5277–5281. doi: 10.1073/pnas.84.15.5277. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fulling K. H., Garcia D. M. Anaplastic astrocytoma of the adult cerebrum. Prognostic value of histologic features. Cancer. 1985 Mar 1;55(5):928–931. doi: 10.1002/1097-0142(19850301)55:5<928::aid-cncr2820550503>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
- Gill G. N., Bertics P. J., Santon J. B. Epidermal growth factor and its receptor. Mol Cell Endocrinol. 1987 Jun;51(3):169–186. doi: 10.1016/0303-7207(87)90027-x. [DOI] [PubMed] [Google Scholar]
- Goldman C. K., Kim J., Wong W. L., King V., Brock T., Gillespie G. Y. Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell. 1993 Jan;4(1):121–133. doi: 10.1091/mbc.4.1.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gospodarowicz D., Bialecki H., Thakral T. K. The angiogenic activity of the fibroblast and epidermal growth factor. Exp Eye Res. 1979 May;28(5):501–514. doi: 10.1016/0014-4835(79)90038-1. [DOI] [PubMed] [Google Scholar]
- Gospodarowicz D., Brown K. D., Birdwell C. R., Zetter B. R. Control of proliferation of human vascular endothelial cells. Characterization of the response of human umbilical vein endothelial cells to fibroblast growth factor, epidermal growth factor, and thrombin. J Cell Biol. 1978 Jun;77(3):774–788. doi: 10.1083/jcb.77.3.774. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gospodarowicz D., Moran J. S. Mitogenic effect of fibroblast growth factor on early passage cultures of human and murine fibroblasts. J Cell Biol. 1975 Aug;66(2):451–457. doi: 10.1083/jcb.66.2.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goto F., Goto K., Weindel K., Folkman J. Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. Lab Invest. 1993 Nov;69(5):508–517. [PubMed] [Google Scholar]
- Gross J. L., Behrens D. L., Mullins D. E., Kornblith P. L., Dexter D. L. Plasminogen activator and inhibitor activity in human glioma cells and modulation by sodium butyrate. Cancer Res. 1988 Jan 15;48(2):291–296. [PubMed] [Google Scholar]
- Grothe C., Zachmann K., Unsicker K. Basic FGF-like immunoreactivity in the developing and adult rat brainstem. J Comp Neurol. 1991 Mar 8;305(2):328–336. doi: 10.1002/cne.903050213. [DOI] [PubMed] [Google Scholar]
- Gómez-Pinilla F., Knauer D. J., Nieto-Sampedro M. Epidermal growth factor receptor immunoreactivity in rat brain. Development and cellular localization. Brain Res. 1988 Jan 12;438(1-2):385–390. doi: 10.1016/0006-8993(88)91369-8. [DOI] [PubMed] [Google Scholar]
- Haudenschild C. C., Zahniser D., Folkman J., Klagsbrun M. Human vascular endothelial cells in culture. Lack of response to serum growth factors. Exp Cell Res. 1976 Mar 1;98(1):175–183. doi: 10.1016/0014-4827(76)90477-8. [DOI] [PubMed] [Google Scholar]
- Heimark R. L., Twardzik D. R., Schwartz S. M. Inhibition of endothelial regeneration by type-beta transforming growth factor from platelets. Science. 1986 Sep 5;233(4768):1078–1080. doi: 10.1126/science.3461562. [DOI] [PubMed] [Google Scholar]
- Helseth E., Dalen A., Unsgaard G., Vik R. Type beta transforming growth factor and epidermal growth factor suppress the plasminogen activator activity in a human glioblastoma cell line. J Neurooncol. 1988 Nov;6(3):277–283. doi: 10.1007/BF00163713. [DOI] [PubMed] [Google Scholar]
- Helseth E., Unsgaard G., Dalen A., Vik R. The effects of type beta transforming growth factor on proliferation and epidermal growth factor receptor expression in a human glioblastoma cell line. J Neurooncol. 1988 Nov;6(3):269–276. doi: 10.1007/BF00163712. [DOI] [PubMed] [Google Scholar]
- Hermanson M., Funa K., Hartman M., Claesson-Welsh L., Heldin C. H., Westermark B., Nistér M. Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res. 1992 Jun 1;52(11):3213–3219. [PubMed] [Google Scholar]
- Hermansson M., Nistér M., Betsholtz C., Heldin C. H., Westermark B., Funa K. Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7748–7752. doi: 10.1073/pnas.85.20.7748. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Herron G. S., Banda M. J., Clark E. J., Gavrilovic J., Werb Z. Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors. J Biol Chem. 1986 Feb 25;261(6):2814–2818. [PubMed] [Google Scholar]
- Honegger P., Guentert-Lauber B. Epidermal growth factor (EGF) stimulation of cultured brain cells. I. Enhancement of the developmental increase in glial enzymatic activity. Brain Res. 1983 Dec;313(2):245–251. doi: 10.1016/0165-3806(83)90222-5. [DOI] [PubMed] [Google Scholar]
- Horst H. A., Scheithauer B. W., Kelly P. J., Kovach J. S. Distribution of transforming growth factor-beta 1 in human astrocytomas. Hum Pathol. 1992 Nov;23(11):1284–1288. doi: 10.1016/0046-8177(92)90297-g. [DOI] [PubMed] [Google Scholar]
- Hutchins J. B., Jefferson V. E. Developmental distribution of platelet-derived growth factor in the mouse central nervous system. Brain Res Dev Brain Res. 1992 Jun 19;67(2):121–135. doi: 10.1016/0165-3806(92)90213-g. [DOI] [PubMed] [Google Scholar]
- Höckel M., Jung W., Vaupel P., Rabes H., Khaledpour C., Wissler J. H. Purified monocyte-derived angiogenic substance (angiotropin) induces controlled angiogenesis associated with regulated tissue proliferation in rabbit skin. J Clin Invest. 1988 Sep;82(3):1075–1090. doi: 10.1172/JCI113664. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ignotz R. A., Massagué J. Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem. 1986 Mar 25;261(9):4337–4345. [PubMed] [Google Scholar]
- Ishikawa F., Miyazono K., Hellman U., Drexler H., Wernstedt C., Hagiwara K., Usuki K., Takaku F., Risau W., Heldin C. H. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature. 1989 Apr 13;338(6216):557–562. doi: 10.1038/338557a0. [DOI] [PubMed] [Google Scholar]
- Jakeman L. B., Winer J., Bennett G. L., Altar C. A., Ferrara N. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest. 1992 Jan;89(1):244–253. doi: 10.1172/JCI115568. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jennings J. C., Mohan S., Linkhart T. A., Widstrom R., Baylink D. J. Comparison of the biological actions of TGF beta-1 and TGF beta-2: differential activity in endothelial cells. J Cell Physiol. 1988 Oct;137(1):167–172. doi: 10.1002/jcp.1041370120. [DOI] [PubMed] [Google Scholar]
- Jennings M. T., Maciunas R. J., Carver R., Bascom C. C., Juneau P., Misulis K., Moses H. L. TGF beta 1 and TGF beta 2 are potential growth regulators for low-grade and malignant gliomas in vitro: evidence in support of an autocrine hypothesis. Int J Cancer. 1991 Aug 19;49(1):129–139. doi: 10.1002/ijc.2910490124. [DOI] [PubMed] [Google Scholar]
- Johnson M. D., Federspiel C. F., Gold L. I., Moses H. L. Transforming growth factor-beta and transforming growth factor beta-receptor expression in human meningioma cells. Am J Pathol. 1992 Sep;141(3):633–642. [PMC free article] [PubMed] [Google Scholar]
- Johnson M. D., Jennings M. T., Gold L. I., Moses H. L. Transforming growth factor-beta in neural embryogenesis and neoplasia. Hum Pathol. 1993 May;24(5):457–462. doi: 10.1016/0046-8177(93)90156-b. [DOI] [PubMed] [Google Scholar]
- Kalebic T., Garbisa S., Glaser B., Liotta L. A. Basement membrane collagen: degradation by migrating endothelial cells. Science. 1983 Jul 15;221(4607):281–283. doi: 10.1126/science.6190230. [DOI] [PubMed] [Google Scholar]
- Kanno H., Kuwabara T., Shinonaga M., Chang C. C., Tanaka Y., Sugio Y., Morita H., Yasumitsu H., Umeda M., Nagashima Y. Establishment of a human glioma cell line bearing a homogeneously staining chromosomal region and releasing alpha- and beta-type transforming growth factors. Acta Neuropathol. 1989;79(1):30–36. doi: 10.1007/BF00308954. [DOI] [PubMed] [Google Scholar]
- Kanno H., Kuwabara T., Yasumitsu H., Umeda M. Transforming growth factors in urine from patients with primary brain tumors. J Neurosurg. 1988 May;68(5):775–780. doi: 10.3171/jns.1988.68.5.0775. [DOI] [PubMed] [Google Scholar]
- Keck P. J., Hauser S. D., Krivi G., Sanzo K., Warren T., Feder J., Connolly D. T. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science. 1989 Dec 8;246(4935):1309–1312. doi: 10.1126/science.2479987. [DOI] [PubMed] [Google Scholar]
- Kelly P. J., Daumas-Duport C., Kispert D. B., Kall B. A., Scheithauer B. W., Illig J. J. Imaging-based stereotaxic serial biopsies in untreated intracranial glial neoplasms. J Neurosurg. 1987 Jun;66(6):865–874. doi: 10.3171/jns.1987.66.6.0865. [DOI] [PubMed] [Google Scholar]
- Kelly P. J., Suddith R. L., Hutchison H. T., Werrbach K., Haber B. Endothelial growth factor present in tissue culture of CNS tumors. J Neurosurg. 1976 Mar;44(3):342–346. doi: 10.3171/jns.1976.44.3.0342. [DOI] [PubMed] [Google Scholar]
- Kieser A., Weich H. A., Brandner G., Marmé D., Kolch W. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene. 1994 Mar;9(3):963–969. [PubMed] [Google Scholar]
- Kim K. J., Li B., Winer J., Armanini M., Gillett N., Phillips H. S., Ferrara N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature. 1993 Apr 29;362(6423):841–844. doi: 10.1038/362841a0. [DOI] [PubMed] [Google Scholar]
- Klagsbrun M., D'Amore P. A. Regulators of angiogenesis. Annu Rev Physiol. 1991;53:217–239. doi: 10.1146/annurev.ph.53.030191.001245. [DOI] [PubMed] [Google Scholar]
- Klagsbrun M., Knighton D., Folkman J. Tumor angiogenesis activity in cells grown in tissue culture. Cancer Res. 1976 Jan;36(1):110–114. [PubMed] [Google Scholar]
- Klagsbrun M., Soker S. VEGF/VPF: the angiogenesis factor found? Curr Biol. 1993 Oct 1;3(10):699–702. doi: 10.1016/0960-9822(93)90073-w. [DOI] [PubMed] [Google Scholar]
- Klein S., Giancotti F. G., Presta M., Albelda S. M., Buck C. A., Rifkin D. B. Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells. Mol Biol Cell. 1993 Oct;4(10):973–982. doi: 10.1091/mbc.4.10.973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Koch A. E., Polverini P. J., Kunkel S. L., Harlow L. A., DiPietro L. A., Elner V. M., Elner S. G., Strieter R. M. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science. 1992 Dec 11;258(5089):1798–1801. doi: 10.1126/science.1281554. [DOI] [PubMed] [Google Scholar]
- Lang F. F., Miller D. C., Koslow M., Newcomb E. W. Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors. J Neurosurg. 1994 Sep;81(3):427–436. doi: 10.3171/jns.1994.81.3.0427. [DOI] [PubMed] [Google Scholar]
- Lee D. C., Rochford R., Todaro G. J., Villarreal L. P. Developmental expression of rat transforming growth factor-alpha mRNA. Mol Cell Biol. 1985 Dec;5(12):3644–3646. doi: 10.1128/mcb.5.12.3644. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leibovich S. J., Polverini P. J., Shepard H. M., Wiseman D. M., Shively V., Nuseir N. Macrophage-induced angiogenesis is mediated by tumour necrosis factor-alpha. Nature. 1987 Oct 15;329(6140):630–632. doi: 10.1038/329630a0. [DOI] [PubMed] [Google Scholar]
- Lens P. F., Altena B., Nusse R. Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea. Mol Cell Biol. 1986 Oct;6(10):3537–3540. doi: 10.1128/mcb.6.10.3537. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leung D. W., Cachianes G., Kuang W. J., Goeddel D. V., Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989 Dec 8;246(4935):1306–1309. doi: 10.1126/science.2479986. [DOI] [PubMed] [Google Scholar]
- Li V. W., Folkerth R. D., Watanabe H., Yu C., Rupnick M., Barnes P., Scott R. M., Black P. M., Sallan S. E., Folkman J. Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours. Lancet. 1994 Jul 9;344(8915):82–86. doi: 10.1016/s0140-6736(94)91280-7. [DOI] [PubMed] [Google Scholar]
- Libermann T. A., Friesel R., Jaye M., Lyall R. M., Westermark B., Drohan W., Schmidt A., Maciag T., Schlessinger J. An angiogenic growth factor is expressed in human glioma cells. EMBO J. 1987 Jun;6(6):1627–1632. doi: 10.1002/j.1460-2075.1987.tb02410.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Libermann T. A., Nusbaum H. R., Razon N., Kris R., Lax I., Soreq H., Whittle N., Waterfield M. D., Ullrich A., Schlessinger J. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature. 1985 Jan 10;313(5998):144–147. doi: 10.1038/313144a0. [DOI] [PubMed] [Google Scholar]
- Liotta L. A., Steeg P. S., Stetler-Stevenson W. G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell. 1991 Jan 25;64(2):327–336. doi: 10.1016/0092-8674(91)90642-c. [DOI] [PubMed] [Google Scholar]
- Liwnicz B. H., Wu S. Z., Tew J. M., Jr The relationship between the capillary structure and hemorrhage in gliomas. J Neurosurg. 1987 Apr;66(4):536–541. doi: 10.3171/jns.1987.66.4.0536. [DOI] [PubMed] [Google Scholar]
- Logan A., Berry M., Thomas G. H., Gregson N. A., Logan S. D. Identification and partial purification of fibroblast growth factor from the brains of developing rats and leucodystrophic mutant mice. Neuroscience. 1985 Aug;15(4):1239–1246. doi: 10.1016/0306-4522(85)90266-0. [DOI] [PubMed] [Google Scholar]
- Long D. M. Capillary ultrastructure and the blood-brain barrier in human malignant brain tumors. J Neurosurg. 1970 Feb;32(2):127–144. doi: 10.3171/jns.1970.32.2.0127. [DOI] [PubMed] [Google Scholar]
- Louis D. N. The p53 gene and protein in human brain tumors. J Neuropathol Exp Neurol. 1994 Jan;53(1):11–21. doi: 10.1097/00005072-199401000-00002. [DOI] [PubMed] [Google Scholar]
- Madri J. A., Pratt B. M., Tucker A. M. Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix. J Cell Biol. 1988 Apr;106(4):1375–1384. doi: 10.1083/jcb.106.4.1375. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Majack R. A., Cook S. C., Bornstein P. Platelet-derived growth factor and heparin-like glycosaminoglycans regulate thrombospondin synthesis and deposition in the matrix by smooth muscle cells. J Cell Biol. 1985 Sep;101(3):1059–1070. doi: 10.1083/jcb.101.3.1059. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mapstone T. B. Expression of platelet-derived growth factor and transforming growth factor and their correlation with cellular morphology in glial tumors. J Neurosurg. 1991 Sep;75(3):447–451. doi: 10.3171/jns.1991.75.3.0447. [DOI] [PubMed] [Google Scholar]
- Marquardt H., Hunkapiller M. W., Hood L. E., Todaro G. J. Rat transforming growth factor type 1: structure and relation to epidermal growth factor. Science. 1984 Mar 9;223(4640):1079–1082. doi: 10.1126/science.6320373. [DOI] [PubMed] [Google Scholar]
- Mascarelli F., Raulais D., Counis M. F., Courtois Y. Characterization of acidic and basic fibroblast growth factors in brain, retina and vitreous chick embryo. Biochem Biophys Res Commun. 1987 Jul 31;146(2):478–486. doi: 10.1016/0006-291x(87)90554-7. [DOI] [PubMed] [Google Scholar]
- Massagué J. Receptors for the TGF-beta family. Cell. 1992 Jun 26;69(7):1067–1070. doi: 10.1016/0092-8674(92)90627-o. [DOI] [PubMed] [Google Scholar]
- Massagué J. The TGF-beta family of growth and differentiation factors. Cell. 1987 May 22;49(4):437–438. doi: 10.1016/0092-8674(87)90443-0. [DOI] [PubMed] [Google Scholar]
- Maxwell M., Galanopoulos T., Hedley-Whyte E. T., Black P. M., Antoniades H. N. Human meningiomas co-express platelet-derived growth factor (PDGF) and PDGF-receptor genes and their protein products. Int J Cancer. 1990 Jul 15;46(1):16–21. doi: 10.1002/ijc.2910460106. [DOI] [PubMed] [Google Scholar]
- Maxwell M., Galanopoulos T., Neville-Golden J., Antoniades H. N. Effect of the expression of transforming growth factor-beta 2 in primary human glioblastomas on immunosuppression and loss of immune surveillance. J Neurosurg. 1992 May;76(5):799–804. doi: 10.3171/jns.1992.76.5.0799. [DOI] [PubMed] [Google Scholar]
- Maxwell M., Naber S. P., Wolfe H. J., Galanopoulos T., Hedley-Whyte E. T., Black P. M., Antoniades H. N. Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance. J Clin Invest. 1990 Jul;86(1):131–140. doi: 10.1172/JCI114675. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Maxwell M., Naber S. P., Wolfe H. J., Hedley-Whyte E. T., Galanopoulos T., Neville-Golden J., Antoniades H. N. Expression of angiogenic growth factor genes in primary human astrocytomas may contribute to their growth and progression. Cancer Res. 1991 Feb 15;51(4):1345–1351. [PubMed] [Google Scholar]
- McAuslan B. R., Bender V., Reilly W., Moss B. A. New functions of epidermal growth factor: stimulation of capillary endothelial cell migration and matrix dependent proliferation. Cell Biol Int Rep. 1985 Feb;9(2):175–182. doi: 10.1016/0309-1651(85)90092-x. [DOI] [PubMed] [Google Scholar]
- McKinnon R. D., Matsui T., Dubois-Dalcq M., Aaronson S. A. FGF modulates the PDGF-driven pathway of oligodendrocyte development. Neuron. 1990 Nov;5(5):603–614. doi: 10.1016/0896-6273(90)90215-2. [DOI] [PubMed] [Google Scholar]
- Mercola M., Stiles C. D. Growth factor superfamilies and mammalian embryogenesis. Development. 1988 Mar;102(3):451–460. doi: 10.1242/dev.102.3.451. [DOI] [PubMed] [Google Scholar]
- Merwin J. R., Newman W., Beall L. D., Tucker A., Madri J. Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro. Am J Pathol. 1991 Jan;138(1):37–51. [PMC free article] [PubMed] [Google Scholar]
- Mignatti P., Tsuboi R., Robbins E., Rifkin D. B. In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases. J Cell Biol. 1989 Feb;108(2):671–682. doi: 10.1083/jcb.108.2.671. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Millauer B., Shawver L. K., Plate K. H., Risau W., Ullrich A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature. 1994 Feb 10;367(6463):576–579. doi: 10.1038/367576a0. [DOI] [PubMed] [Google Scholar]
- Millauer B., Wizigmann-Voos S., Schnürch H., Martinez R., Møller N. P., Risau W., Ullrich A. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell. 1993 Mar 26;72(6):835–846. doi: 10.1016/0092-8674(93)90573-9. [DOI] [PubMed] [Google Scholar]
- Miyazono K., Heldin C. H. Role for carbohydrate structures in TGF-beta 1 latency. Nature. 1989 Mar 9;338(6211):158–160. doi: 10.1038/338158a0. [DOI] [PubMed] [Google Scholar]
- Montesano R., Vassalli J. D., Baird A., Guillemin R., Orci L. Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci U S A. 1986 Oct;83(19):7297–7301. doi: 10.1073/pnas.83.19.7297. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mooradian D. L., Lucas R. C., Weatherbee J. A., Furcht L. T. Transforming growth factor-beta 1 binds to immobilized fibronectin. J Cell Biochem. 1989 Dec;41(4):189–200. doi: 10.1002/jcb.240410404. [DOI] [PubMed] [Google Scholar]
- Moringlane J. R., Spinas R., Böhlen P. Acidic fibroblast growth factor (aFGF) is present in the fluid of brain tumour pseudocysts. Acta Neurochir (Wien) 1990;107(3-4):88–92. doi: 10.1007/BF01405785. [DOI] [PubMed] [Google Scholar]
- Morrison R. S., Gross J. L., Herblin W. F., Reilly T. M., LaSala P. A., Alterman R. L., Moskal J. R., Kornblith P. L., Dexter D. L. Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line. Cancer Res. 1990 Apr 15;50(8):2524–2529. [PubMed] [Google Scholar]
- Morrison R. S., Sharma A., de Vellis J., Bradshaw R. A. Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture. Proc Natl Acad Sci U S A. 1986 Oct;83(19):7537–7541. doi: 10.1073/pnas.83.19.7537. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morrison R. S. Suppression of basic fibroblast growth factor expression by antisense oligodeoxynucleotides inhibits the growth of transformed human astrocytes. J Biol Chem. 1991 Jan 15;266(2):728–734. [PubMed] [Google Scholar]
- Morrison R. S., Yamaguchi F., Bruner J. M., Tang M., McKeehan W., Berger M. S. Fibroblast growth factor receptor gene expression and immunoreactivity are elevated in human glioblastoma multiforme. Cancer Res. 1994 May 15;54(10):2794–2799. [PubMed] [Google Scholar]
- Moscatelli D., Presta M., Rifkin D. B. Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration. Proc Natl Acad Sci U S A. 1986 Apr;83(7):2091–2095. doi: 10.1073/pnas.83.7.2091. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moscatelli D., Rifkin D. B. Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis. Biochim Biophys Acta. 1988 Aug 3;948(1):67–85. doi: 10.1016/0304-419x(88)90005-4. [DOI] [PubMed] [Google Scholar]
- Moses H. L., Yang E. Y., Pietenpol J. A. TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights. Cell. 1990 Oct 19;63(2):245–247. doi: 10.1016/0092-8674(90)90155-8. [DOI] [PubMed] [Google Scholar]
- Murphy P. R., Myal Y., Sato Y., Sato R., West M., Friesen H. G. Elevated expression of basic fibroblast growth factor messenger ribonucleic acid in acoustic neuromas. Mol Endocrinol. 1989 Feb;3(2):225–231. doi: 10.1210/mend-3-2-225. [DOI] [PubMed] [Google Scholar]
- Murphy P. R., Sato R., Sato Y., Friesen H. G. Fibroblast growth factor messenger ribonucleic acid expression in a human astrocytoma cell line: regulation by serum and cell density. Mol Endocrinol. 1988 Jul;2(7):591–598. doi: 10.1210/mend-2-7-591. [DOI] [PubMed] [Google Scholar]
- Nicosia R. F., Madri J. A. The microvascular extracellular matrix. Developmental changes during angiogenesis in the aortic ring-plasma clot model. Am J Pathol. 1987 Jul;128(1):78–90. [PMC free article] [PubMed] [Google Scholar]
- Nishio S., Ohta M., Abe M., Kitamura K. Microvascular abnormalities in ethylnitrosourea (ENU)-induced rat brain tumors: structural basis for altered blood-brain barrier function. Acta Neuropathol. 1983;59(1):1–10. doi: 10.1007/BF00690311. [DOI] [PubMed] [Google Scholar]
- Nistér M., Libermann T. A., Betsholtz C., Pettersson M., Claesson-Welsh L., Heldin C. H., Schlessinger J., Westermark B. Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines. Cancer Res. 1988 Jul 15;48(14):3910–3918. [PubMed] [Google Scholar]
- Nitta T., Sato K., Okumura K. Transforming growth factor (TGF)-beta like activity of intracranial meningioma and its effect on cell growth. J Neurol Sci. 1991 Jan;101(1):19–23. doi: 10.1016/0022-510x(91)90014-x. [DOI] [PubMed] [Google Scholar]
- Noble M., Murray K., Stroobant P., Waterfield M. D., Riddle P. Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell. Nature. 1988 Jun 9;333(6173):560–562. doi: 10.1038/333560a0. [DOI] [PubMed] [Google Scholar]
- Nugent M. A., Edelman E. R. Transforming growth factor beta 1 stimulates the production of basic fibroblast growth factor binding proteoglycans in Balb/c3T3 cells. J Biol Chem. 1992 Oct 15;267(29):21256–21264. [PubMed] [Google Scholar]
- Olofsson A., Miyazono K., Kanzaki T., Colosetti P., Engström U., Heldin C. H. Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes. J Biol Chem. 1992 Sep 25;267(27):19482–19488. [PubMed] [Google Scholar]
- Overall C. M., Wrana J. L., Sodek J. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J Biol Chem. 1989 Jan 25;264(3):1860–1869. [PubMed] [Google Scholar]
- Pantazis P., Pelicci P. G., Dalla-Favera R., Antoniades H. N. Synthesis and secretion of proteins resembling platelet-derived growth factor by human glioblastoma and fibrosarcoma cells in culture. Proc Natl Acad Sci U S A. 1985 Apr;82(8):2404–2408. doi: 10.1073/pnas.82.8.2404. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Paulus W., Grothe C., Sensenbrenner M., Janet T., Baur I., Graf M., Roggendorf W. Localization of basic fibroblast growth factor, a mitogen and angiogenic factor, in human brain tumors. Acta Neuropathol. 1990;79(4):418–423. doi: 10.1007/BF00308718. [DOI] [PubMed] [Google Scholar]
- Pelton R. W., Saxena B., Jones M., Moses H. L., Gold L. I. Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. J Cell Biol. 1991 Nov;115(4):1091–1105. doi: 10.1083/jcb.115.4.1091. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pepper M. S., Belin D., Montesano R., Orci L., Vassalli J. D. Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. J Cell Biol. 1990 Aug;111(2):743–755. doi: 10.1083/jcb.111.2.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pepper M. S., Ferrara N., Orci L., Montesano R. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun. 1991 Dec 16;181(2):902–906. doi: 10.1016/0006-291x(91)91276-i. [DOI] [PubMed] [Google Scholar]
- Pertovaara L., Kaipainen A., Mustonen T., Orpana A., Ferrara N., Saksela O., Alitalo K. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J Biol Chem. 1994 Mar 4;269(9):6271–6274. [PubMed] [Google Scholar]
- Plate K. H., Breier G., Farrell C. L., Risau W. Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas. Lab Invest. 1992 Oct;67(4):529–534. [PubMed] [Google Scholar]
- Plate K. H., Breier G., Millauer B., Ullrich A., Risau W. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res. 1993 Dec 1;53(23):5822–5827. [PubMed] [Google Scholar]
- Plate K. H., Breier G., Weich H. A., Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature. 1992 Oct 29;359(6398):845–848. doi: 10.1038/359845a0. [DOI] [PubMed] [Google Scholar]
- Plouët J., Gospodarowicz D. Transforming growth factor beta-1 positively modulates the bioactivity of fibroblast growth factor on corneal endothelial cells. J Cell Physiol. 1989 Nov;141(2):392–399. doi: 10.1002/jcp.1041410221. [DOI] [PubMed] [Google Scholar]
- Postlethwaite A. E., Keski-Oja J., Moses H. L., Kang A. H. Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta. J Exp Med. 1987 Jan 1;165(1):251–256. doi: 10.1084/jem.165.1.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Quirion R., Araujo D., Nair N. P., Chabot J. G. Visualization of growth factor receptor sites in rat forebrain. Synapse. 1988;2(3):212–218. doi: 10.1002/syn.890020307. [DOI] [PubMed] [Google Scholar]
- Raff M. C. Glial cell diversification in the rat optic nerve. Science. 1989 Mar 17;243(4897):1450–1455. doi: 10.1126/science.2648568. [DOI] [PubMed] [Google Scholar]
- Raff M. C., Lillien L. E., Richardson W. D., Burne J. F., Noble M. D. Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture. Nature. 1988 Jun 9;333(6173):562–565. doi: 10.1038/333562a0. [DOI] [PubMed] [Google Scholar]
- Rao J. S., Steck P. A., Mohanam S., Stetler-Stevenson W. G., Liotta L. A., Sawaya R. Elevated levels of M(r) 92,000 type IV collagenase in human brain tumors. Cancer Res. 1993 May 15;53(10 Suppl):2208–2211. [PubMed] [Google Scholar]
- Reibman J., Meixler S., Lee T. C., Gold L. I., Cronstein B. N., Haines K. A., Kolasinski S. L., Weissmann G. Transforming growth factor beta 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways. Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6805–6809. doi: 10.1073/pnas.88.15.6805. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reid H. H., Wilks A. F., Bernard O. Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1596–1600. doi: 10.1073/pnas.87.4.1596. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reynolds B. A., Tetzlaff W., Weiss S. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J Neurosci. 1992 Nov;12(11):4565–4574. doi: 10.1523/JNEUROSCI.12-11-04565.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reynolds R., Wilkin G. P. Development of macroglial cells in rat cerebellum. II. An in situ immunohistochemical study of oligodendroglial lineage from precursor to mature myelinating cell. Development. 1988 Feb;102(2):409–425. doi: 10.1242/dev.102.2.409. [DOI] [PubMed] [Google Scholar]
- Rifkin D. B., Moscatelli D. Recent developments in the cell biology of basic fibroblast growth factor. J Cell Biol. 1989 Jul;109(1):1–6. doi: 10.1083/jcb.109.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Risau W. Developing brain produces an angiogenesis factor. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3855–3859. doi: 10.1073/pnas.83.11.3855. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Risau W., Drexler H., Mironov V., Smits A., Siegbahn A., Funa K., Heldin C. H. Platelet-derived growth factor is angiogenic in vivo. Growth Factors. 1992;7(4):261–266. doi: 10.3109/08977199209046408. [DOI] [PubMed] [Google Scholar]
- Risau W., Gautschi-Sova P., Böhlen P. Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor. EMBO J. 1988 Apr;7(4):959–962. doi: 10.1002/j.1460-2075.1988.tb02901.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Risau W., Lemmon V. Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis. Dev Biol. 1988 Feb;125(2):441–450. doi: 10.1016/0012-1606(88)90225-4. [DOI] [PubMed] [Google Scholar]
- Roberts A. B., Sporn M. B., Assoian R. K., Smith J. M., Roche N. S., Wakefield L. M., Heine U. I., Liotta L. A., Falanga V., Kehrl J. H. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A. 1986 Jun;83(12):4167–4171. doi: 10.1073/pnas.83.12.4167. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roberts A. B., Sporn M. B. Transforming growth factors. Cancer Surv. 1985;4(4):683–705. [PubMed] [Google Scholar]
- Rogelj S., Weinberg R. A., Fanning P., Klagsbrun M. Basic fibroblast growth factor fused to a signal peptide transforms cells. Nature. 1988 Jan 14;331(6152):173–175. doi: 10.1038/331173a0. [DOI] [PubMed] [Google Scholar]
- Ryken T. C., Traynelis V. C., Lim R. Interaction of acidic fibroblast growth factor and transforming growth factor-beta in normal and transformed glia in vitro. J Neurosurg. 1992 May;76(5):850–855. doi: 10.3171/jns.1992.76.5.0850. [DOI] [PubMed] [Google Scholar]
- Saksela O., Moscatelli D., Rifkin D. B. The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells. J Cell Biol. 1987 Aug;105(2):957–963. doi: 10.1083/jcb.105.2.957. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saksela O., Rifkin D. B. Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity. J Cell Biol. 1990 Mar;110(3):767–775. doi: 10.1083/jcb.110.3.767. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Samuels V., Barrett J. M., Bockman S., Pantazis C. G., Allen M. B., Jr Immunocytochemical study of transforming growth factor expression in benign and malignant gliomas. Am J Pathol. 1989 Apr;134(4):894–902. [PMC free article] [PubMed] [Google Scholar]
- Sasahara A., Kott J. N., Sasahara M., Raines E. W., Ross R., Westrum L. E. Platelet-derived growth factor B-chain-like immunoreactivity in the developing and adult rat brain. Brain Res Dev Brain Res. 1992 Jul 24;68(1):41–53. doi: 10.1016/0165-3806(92)90246-s. [DOI] [PubMed] [Google Scholar]
- Sato N., Beitz J. G., Kato J., Yamamoto M., Clark J. W., Calabresi P., Raymond A., Frackelton A. R., Jr Platelet-derived growth factor indirectly stimulates angiogenesis in vitro. Am J Pathol. 1993 Apr;142(4):1119–1130. [PMC free article] [PubMed] [Google Scholar]
- Sato Y., Murphy P. R., Sato R., Friesen H. G. Fibroblast growth factor release by bovine endothelial cells and human astrocytoma cells in culture is density dependent. Mol Endocrinol. 1989 Apr;3(4):744–748. doi: 10.1210/mend-3-4-744. [DOI] [PubMed] [Google Scholar]
- Sato Y., Tsuboi R., Lyons R., Moses H., Rifkin D. B. Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system. J Cell Biol. 1990 Aug;111(2):757–763. doi: 10.1083/jcb.111.2.757. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schlessinger J. Regulation of cell growth and transformation by the epidermal growth factor receptor. Adv Exp Med Biol. 1988;234:65–73. doi: 10.1007/978-1-4757-1980-2_6. [DOI] [PubMed] [Google Scholar]
- Schnürch H., Risau W. Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development. Development. 1991 Apr;111(4):1143–1154. doi: 10.1242/dev.111.4.1143. [DOI] [PubMed] [Google Scholar]
- Schreiber A. B., Winkler M. E., Derynck R. Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor. Science. 1986 Jun 6;232(4755):1250–1253. doi: 10.1126/science.2422759. [DOI] [PubMed] [Google Scholar]
- Schultz-Cherry S., Murphy-Ullrich J. E. Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism. J Cell Biol. 1993 Aug;122(4):923–932. doi: 10.1083/jcb.122.4.923. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schöllmann C., Grugel R., Tatje D., Hoppe J., Folkman J., Marmé D., Weich H. A. Basic fibroblast growth factor modulates the mitogenic potency of the platelet-derived growth factor (PDGF) isoforms by specific upregulation of the PDGF alpha receptor in vascular smooth muscle cells. J Biol Chem. 1992 Sep 5;267(25):18032–18039. [PubMed] [Google Scholar]
- Senger D. R., Connolly D. T., Van de Water L., Feder J., Dvorak H. F. Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res. 1990 Mar 15;50(6):1774–1778. [PubMed] [Google Scholar]
- Shing Y. Heparin-copper biaffinity chromatography of fibroblast growth factors. J Biol Chem. 1988 Jun 25;263(18):9059–9062. [PubMed] [Google Scholar]
- Shiurba R. A., Buffinger N. S., Spencer E. M., Urich H. Basic fibroblast growth factor and somatomedin C in human medulloepithelioma. Cancer. 1991 Aug 15;68(4):798–808. doi: 10.1002/1097-0142(19910815)68:4<798::aid-cncr2820680423>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
- Shweiki D., Itin A., Soffer D., Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 1992 Oct 29;359(6398):843–845. doi: 10.1038/359843a0. [DOI] [PubMed] [Google Scholar]
- Simpson D. L., Morrison R., de Vellis J., Herschman H. R. Epidermal growth factor binding and mitogenic activity on purified populations of cells from the central nervous system. J Neurosci Res. 1982;8(2-3):453–462. doi: 10.1002/jnr.490080233. [DOI] [PubMed] [Google Scholar]
- Smith J. M., Sporn M. B., Roberts A. B., Derynck R., Winkler M. E., Gregory H. Human transforming growth factor-alpha causes precocious eyelid opening in newborn mice. Nature. 1985 Jun 6;315(6019):515–516. doi: 10.1038/315515a0. [DOI] [PubMed] [Google Scholar]
- Sriramarao P., Mendler M., Bourdon M. A. Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins. J Cell Sci. 1993 Aug;105(Pt 4):1001–1012. doi: 10.1242/jcs.105.4.1001. [DOI] [PubMed] [Google Scholar]
- Starksen N. F., Harsh G. R., 4th, Gibbs V. C., Williams L. T. Regulated expression of the platelet-derived growth factor A chain gene in microvascular endothelial cells. J Biol Chem. 1987 Oct 25;262(30):14381–14384. [PubMed] [Google Scholar]
- Steck P. A., Moser R. P., Bruner J. M., Liang L., Freidman A. N., Hwang T. L., Yung W. K. Altered expression and distribution of heparan sulfate proteoglycans in human gliomas. Cancer Res. 1989 Apr 15;49(8):2096–2103. [PubMed] [Google Scholar]
- Stefanik D. F., Rizkalla L. R., Soi A., Goldblatt S. A., Rizkalla W. M. Acidic and basic fibroblast growth factors are present in glioblastoma multiforme. Cancer Res. 1991 Oct 15;51(20):5760–5765. [PubMed] [Google Scholar]
- Stoscheck C. M., King L. E., Jr Functional and structural characteristics of EGF and its receptor and their relationship to transforming proteins. J Cell Biochem. 1986;31(2):135–152. doi: 10.1002/jcb.240310206. [DOI] [PubMed] [Google Scholar]
- Stoscheck C. M., King L. E., Jr Role of epidermal growth factor in carcinogenesis. Cancer Res. 1986 Mar;46(3):1030–1037. [PubMed] [Google Scholar]
- Stromberg K., Hudgins W. R., Dorman L. S., Henderson L. E., Sowder R. C., Sherrell B. J., Mount C. D., Orth D. N. Human brain tumor-associated urinary high molecular weight transforming growth factor: a high molecular weight form of epidermal growth factor. Cancer Res. 1987 Feb 15;47(4):1190–1196. [PubMed] [Google Scholar]
- Takahashi J. A., Fukumoto M., Igarashi K., Oda Y., Kikuchi H., Hatanaka M. Correlation of basic fibroblast growth factor expression levels with the degree of malignancy and vascularity in human gliomas. J Neurosurg. 1992 May;76(5):792–798. doi: 10.3171/jns.1992.76.5.0792. [DOI] [PubMed] [Google Scholar]
- Takahashi J. A., Fukumoto M., Kozai Y., Ito N., Oda Y., Kikuchi H., Hatanaka M. Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor. FEBS Lett. 1991 Aug 19;288(1-2):65–71. doi: 10.1016/0014-5793(91)81004-r. [DOI] [PubMed] [Google Scholar]
- Takahashi J. A., Mori H., Fukumoto M., Igarashi K., Jaye M., Oda Y., Kikuchi H., Hatanaka M. Gene expression of fibroblast growth factors in human gliomas and meningiomas: demonstration of cellular source of basic fibroblast growth factor mRNA and peptide in tumor tissues. Proc Natl Acad Sci U S A. 1990 Aug;87(15):5710–5714. doi: 10.1073/pnas.87.15.5710. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Takahashi J. A., Suzui H., Yasuda Y., Ito N., Ohta M., Jaye M., Fukumoto M., Oda Y., Kikuchi H., Hatanaka M. Gene expression of fibroblast growth factor receptors in the tissues of human gliomas and meningiomas. Biochem Biophys Res Commun. 1991 May 31;177(1):1–7. doi: 10.1016/0006-291x(91)91939-a. [DOI] [PubMed] [Google Scholar]
- Tam J. P., Marquardt H., Rosberger D. F., Wong T. W., Todaro G. J. Synthesis of biologically active rat transforming growth factor I. Nature. 1984 May 24;309(5966):376–378. doi: 10.1038/309376a0. [DOI] [PubMed] [Google Scholar]
- Taraboletti G., Roberts D., Liotta L. A., Giavazzi R. Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor. J Cell Biol. 1990 Aug;111(2):765–772. doi: 10.1083/jcb.111.2.765. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Terman B. I., Dougher-Vermazen M., Carrion M. E., Dimitrov D., Armellino D. C., Gospodarowicz D., Böhlen P. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun. 1992 Sep 30;187(3):1579–1586. doi: 10.1016/0006-291x(92)90483-2. [DOI] [PubMed] [Google Scholar]
- Tsunawaki S., Sporn M., Ding A., Nathan C. Deactivation of macrophages by transforming growth factor-beta. Nature. 1988 Jul 21;334(6179):260–262. doi: 10.1038/334260a0. [DOI] [PubMed] [Google Scholar]
- Ueba T., Takahashi J. A., Fukumoto M., Ohta M., Ito N., Oda Y., Kikuchi H., Hatanaka M. Expression of fibroblast growth factor receptor-1 in human glioma and meningioma tissues. Neurosurgery. 1994 Feb;34(2):221–226. doi: 10.1227/00006123-199402000-00003. [DOI] [PubMed] [Google Scholar]
- Unemori E. N., Ferrara N., Bauer E. A., Amento E. P. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol. 1992 Dec;153(3):557–562. doi: 10.1002/jcp.1041530317. [DOI] [PubMed] [Google Scholar]
- Vallee B. L., Riordan J. F. Chemical and biochemical properties of human angiogenin. Adv Exp Med Biol. 1988;234:41–53. doi: 10.1007/978-1-4757-1980-2_4. [DOI] [PubMed] [Google Scholar]
- Vlodavsky I., Folkman J., Sullivan R., Fridman R., Ishai-Michaeli R., Sasse J., Klagsbrun M. Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix. Proc Natl Acad Sci U S A. 1987 Apr;84(8):2292–2296. doi: 10.1073/pnas.84.8.2292. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wahl S. M., Hunt D. A., Wakefield L. M., McCartney-Francis N., Wahl L. M., Roberts A. B., Sporn M. B. Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5788–5792. doi: 10.1073/pnas.84.16.5788. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weindel K., Moringlane J. R., Marmé D., Weich H. A. Detection and quantification of vascular endothelial growth factor/vascular permeability factor in brain tumor tissue and cyst fluid: the key to angiogenesis? Neurosurgery. 1994 Sep;35(3):439–449. doi: 10.1227/00006123-199409000-00012. [DOI] [PubMed] [Google Scholar]
- Westphal M., Brunken M., Rohde E., Herrmann H. D. Growth factors in cultured human glioma cells: differential effects of FGF, EGF and PDGF. Cancer Lett. 1988 Jan;38(3):283–296. doi: 10.1016/0304-3835(88)90020-1. [DOI] [PubMed] [Google Scholar]
- Wong A. J., Bigner S. H., Bigner D. D., Kinzler K. W., Hamilton S. R., Vogelstein B. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci U S A. 1987 Oct;84(19):6899–6903. doi: 10.1073/pnas.84.19.6899. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yeh H. J., Ruit K. G., Wang Y. X., Parks W. C., Snider W. D., Deuel T. F. PDGF A-chain gene is expressed by mammalian neurons during development and in maturity. Cell. 1991 Jan 11;64(1):209–216. doi: 10.1016/0092-8674(91)90222-k. [DOI] [PubMed] [Google Scholar]
- Zagzag D., Brem S., Robert F. Neovascularization and tumor growth in the rabbit brain. A model for experimental studies of angiogenesis and the blood-brain barrier. Am J Pathol. 1988 May;131(2):361–372. [PMC free article] [PubMed] [Google Scholar]
- Zagzag D., Miller D. C., Sato Y., Rifkin D. B., Burstein D. E. Immunohistochemical localization of basic fibroblast growth factor in astrocytomas. Cancer Res. 1990 Nov 15;50(22):7393–7398. [PubMed] [Google Scholar]
- Zuccarello M., Sawaya R., Ray M. B. Immunohistochemical demonstration of alpha-1-proteinase inhibitor in brain tumors. Cancer. 1987 Aug 15;60(4):804–809. doi: 10.1002/1097-0142(19870815)60:4<804::aid-cncr2820600416>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
- de Vries C., Escobedo J. A., Ueno H., Houck K., Ferrara N., Williams L. T. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science. 1992 Feb 21;255(5047):989–991. doi: 10.1126/science.1312256. [DOI] [PubMed] [Google Scholar]
- von Deimling A., Louis D. N., von Ammon K., Petersen I., Hoell T., Chung R. Y., Martuza R. L., Schoenfeld D. A., Yaşargil M. G., Wiestler O. D. Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme. J Neurosurg. 1992 Aug;77(2):295–301. doi: 10.3171/jns.1992.77.2.0295. [DOI] [PubMed] [Google Scholar]