Skip to main content
PMC home page
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1983 Jul 15;129(2):132–135.

Utilisation des céphalosporines comme antibioprophylaxie lors de césariennes.

Use of cephalosporins as antibiotic prophylaxis in cesarean section

P Fugère, P Turgeon, M Boucher, G Verschelden, M Lemay
PMCID: PMC1875263  PMID: 6344970

Abstract

Cefoxitin, a second-generation cephalosporin, was compared with cefazolin, a first-generation cephalosporin, and a placebo in a prospective, double-blind study of antibiotic prophylaxis in women undergoing nonelective cesarean section. In the groups that received cefazolin or the placebo there eas no statistically significant change in colonization of the cervix by aerobic bacteria by the fourth day after the operation, but there was a statistically significant increase in colonization by anaerobes. Cefoxitin had the opposite effect. Of the 14 postoperative infections in 11 patients, significantly more were in patients who had received the placebo; the numbers were too small to show a difference in effectiveness between the two antibiotics. Of the microorganisms implicated as the infectious agents, group B Streptococcus was the most frequent aerobe, and Peptostreptococcus and Bacteroides bivius were the most frequent anaerobes. Among the 15 patients for whom at least one perioperative specimen yielded positive culture results, a postoperative infection developed in 5 of the 6 who received the placebo, 2 of the 4 who received cefazolin and 1 of the 5 who received cefoxitin.

Full text

PDF
134

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chow A. W. Antimicrobial therapy of gynaecological infections: an overview. J Antimicrob Chemother. 1982 Jan;9 (Suppl A):139–147. doi: 10.1093/jac/9.suppl_a.139. [DOI] [PubMed] [Google Scholar]
  2. Cunningham F. G., Hauth J. C., Strong J. D., Kappus S. S. Infectious morbidity following cesarean section. Comparison of two treatment regimens. Obstet Gynecol. 1978 Dec;52(6):656–661. [PubMed] [Google Scholar]
  3. D'Angelo L. J., Sokol R. J. Short- versus long-course prophylactic antibiotic treatment in Cesarean section patients. Obstet Gynecol. 1980 May;55(5):583–586. [PubMed] [Google Scholar]
  4. De Palma R. T., Leveno K. J., Cunningham F. G., Pope T., Kappus S. S., Roark M. L., Nobles B. J. Identification and management of women at high risk for pelvic infection following cesarean section. Obstet Gynecol. 1980 May;55(5 Suppl):185S–192S. doi: 10.1097/00006250-198003001-00047. [DOI] [PubMed] [Google Scholar]
  5. Dillon W. P., Seigel M. S., Lele A. S., O'Leary J. A. Evaluation of cefoxitin prophylaxis for cesarean section. Int J Gynaecol Obstet. 1981 Apr;19(2):133–139. doi: 10.1016/0020-7292(81)90052-7. [DOI] [PubMed] [Google Scholar]
  6. Gibbs R. S., Hunt J. E., Schwarz R. H. A follow-up study on prophylactic antibiotics in cesarean section. Am J Obstet Gynecol. 1973 Oct 1;117(3):419–422. doi: 10.1016/0002-9378(73)90050-1. [DOI] [PubMed] [Google Scholar]
  7. Gibbs R. S., St Clair P. J., Castillo M. S., Castaneda Y. S. Bacteriologic effects of antibiotic prophylaxis in high-risk cesarean section. Obstet Gynecol. 1981 Mar;57(3):277–282. [PubMed] [Google Scholar]
  8. Harger J. H., English D. H. Selection of patients for antibiotic prophylaxis in cesarean sections. Am J Obstet Gynecol. 1981 Dec 1;141(7):752–758. doi: 10.1016/0002-9378(81)90699-2. [DOI] [PubMed] [Google Scholar]
  9. Itskovitz J., Paldi E., Katz M. The effect of prophylactic antibiotics on febrile morbidity following cesarean section. Obstet Gynecol. 1979 Feb;53(2):162–165. [PubMed] [Google Scholar]
  10. Kreutner A. K., Del Bene V. E., Delamar D., Bodden J. L., Loadholt C. B. Perioperative cephalosporin prophylaxis in cesarean section: effect on endometritis in the high-risk patient. Am J Obstet Gynecol. 1979 Aug 15;134(8):925–935. doi: 10.1016/0002-9378(79)90868-8. [DOI] [PubMed] [Google Scholar]
  11. Kreutner A. K., del Bene V. E., Delamar D., Huguley V., Harmon P. M., Mitchell K. S. Perioperative antibiotic prophylaxis is cesarean section. Obstet Gynecol. 1978 Sep;52(3):279–284. [PubMed] [Google Scholar]
  12. Moro M., Andrews M. Prophylactic antibiotics in cesarean section. Obstet Gynecol. 1974 Nov;44(5):688–692. [PubMed] [Google Scholar]
  13. Stiver H. G., Forward K. R., Livingstone R. A., Fugère P., Lemay M., Verschelden G., Hunter J. D., Carson G. D., Beresford P., Tyrrell D. L. Multicenter comparison of cefoxitin versus cefazolin for prevention of infectious morbidity after nonelective cesarean section. Am J Obstet Gynecol. 1983 Jan 15;145(2):158–163. doi: 10.1016/0002-9378(83)90483-0. [DOI] [PubMed] [Google Scholar]
  14. Wong R., Gee C. L., Ledger W. J. Prophylactic use of cefazolin in monitored obstetric patients undergoing cesarean section. Obstet Gynecol. 1978 Apr;51(4):407–411. doi: 10.1097/00006250-197804000-00004. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES