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. 1990 Aug;137(2):259–262.

Osteosarcomas in transgenic mice expressing an alpha-amylase-SV40 T-antigen hybrid gene.

B B Knowles 1, J McCarrick 1, N Fox 1, D Solter 1, I Damjanov 1
PMCID: PMC1877617  PMID: 2386195

Abstract

Mice of a transgenic mouse lineage 501, produced by zygotic injection of the parotid alpha-amylase promoter-SV40 T-antigen hybrid gene, developed osteosarcomas at about 15 months of age. The tumors predominantly involved the axial skeleton, were sometimes multiple, and metastasized to the liver. A cell line derived from a primary tumor produced osteosarcomas on transfer to nude mice. The 501 transgenic lineage thus provides a valuable new model for studying the histogenesis of osteosarcomas.

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Selected References

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