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. 1976 Nov 6;115(9):871–873.

Miliary tuberculosis presenting with hyponatremia and thrombocytopenia.

D W Cockcroft, R E Donevan, G M Copland, J W Ibbott
PMCID: PMC1879092  PMID: 991033

Abstract

A 74-year-old woman with miliary tuberculosis had moderately severe hyponatremia due to inappropriate secretion of antidiuretic hormone (SIADH) and very severe thrombocytopenia without other hematologic abnormalities. She was treated with isoniazid, rifampin, ethambutol, prednisone, vincristine and fluid restriction and recovered completely. The SIADH may have been a response by the posterior pituitary to a decrease in intravascular volume resulting from the extensive pulmonary disease or associated hypoxia, or the tuberculous lung may have released ADH or an ADH-like substance. The thrombocytopenia may have resulted from a direct or indirect toxic effect of infection or, less likely, the tuberculosis may have activated latent idiopathic thrombocytopenic purpura.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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