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. 1989 Sep;135(3):529–540.

Uniform lineage of oligodendrogliomas.

S M de la Monte 1
PMCID: PMC1879866  PMID: 2675625

Abstract

Experimental observations provide evidence that galactocerebroside-containing (GC+) oligodendrocytes and glial fibrillary acidic protein-containing (GFAP+) type 2 astrocytes are derived from A2B5+ progenitor cells. Because the cytomorphologic features of oligodendrogliomas resemble those of non-neoplastic oligodendrocytes, it was speculated that neoplastic oligodendroglial cells also have A2B5+ lineage. This hypothesis was investigated by immunostaining histopathologic sections with monoclonal antibodies to GC, A2B5, and GFAP. In 28 tumors, ubiquitous immunolabeling of neoplastic cells with anti-GC and anti-A2B5 was observed. In addition, GFAP+/A2B5+ astrocytes were present in most mixed glial tumors. The findings suggest that oligodendrogliomas, whether or not they contain foci of astrocytoma, are uniformly derived from A2B5+ progenitor cells.

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Selected References

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