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. 1988 Jul;132(1):167–172.

beta-amyloid protein of Alzheimer's disease is found in cerebral and spinal cord vascular malformations.

M N Hart 1, P Merz 1, J Bennett-Gray 1, A H Menezes 1, J A Goeken 1, R L Schelper 1, H M Wisniewski 1
PMCID: PMC1880626  PMID: 3293463

Abstract

Congo/Red deposition with birefringence to polarized light was demonstrated focally in cerebrovascular malformations removed surgically from 4 older patients (ages 85, 74, 74, and 63), and in a spinal cord vascular malformation in a 76-year-old patient. Lesser degrees of Congophilic change were observed in cerebrovascular malformations screened from 4 of 10 patients between the ages of 30 and 59. No Congophilic change was seen in 10 cerebrovascular malformations removed from patients under 30 years of age. Congophilic areas in all cases decorated with W-2 and 85/45 polyclonal antibodies raised to peptide sequences of cerebrovascular beta-amyloid and beta-amyloid of senile plaques from patients with Alzheimer's disease. Thus, the amyloid in these vascular malformations is immunologically related to beta-amyloid protein. This finding provides another indication that vascular beta-amyloid deposition is not specific for Alzheimer's disease and suggests that an existing abnormality of vessels may be a predisposing factor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bahmanyar S., Higgins G. A., Goldgaber D., Lewis D. A., Morrison J. H., Wilson M. C., Shankar S. K., Gajdusek D. C. Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease. Science. 1987 Jul 3;237(4810):77–80. doi: 10.1126/science.3299701. [DOI] [PubMed] [Google Scholar]
  2. Eikelenboom P., Stam F. C. An immunohistochemical study on cerebral vascular and senile plaque amyloid in Alzheimer's dementia. Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;47(1):17–25. doi: 10.1007/BF02890185. [DOI] [PubMed] [Google Scholar]
  3. Glenner G. G. Alzheimer's disease. The commonest form of amyloidosis. Arch Pathol Lab Med. 1983 Jun;107(6):281–282. [PubMed] [Google Scholar]
  4. Glenner G. G., Wong C. W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun. 1984 May 16;120(3):885–890. doi: 10.1016/s0006-291x(84)80190-4. [DOI] [PubMed] [Google Scholar]
  5. Goldgaber D., Lerman M. I., McBride O. W., Saffiotti U., Gajdusek D. C. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science. 1987 Feb 20;235(4791):877–880. doi: 10.1126/science.3810169. [DOI] [PubMed] [Google Scholar]
  6. Goust J. M., Mangum M., Powers J. M. An immunologic assessment of brain-associated IgG in senile cerebral amyloidosis. J Neuropathol Exp Neurol. 1984 Sep;43(5):481–488. doi: 10.1097/00005072-198409000-00003. [DOI] [PubMed] [Google Scholar]
  7. Hsu S. M., Raine L., Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981 Apr;29(4):577–580. doi: 10.1177/29.4.6166661. [DOI] [PubMed] [Google Scholar]
  8. Kitamoto T., Tashima T., Tateishi J. Novel histochemical approaches to the prealbumin-related senile and familial forms of systemic amyloidosis. Am J Pathol. 1986 Jun;123(3):407–412. [PMC free article] [PubMed] [Google Scholar]
  9. Löfberg H., Grubb A. O., Nilsson E. K., Jensson O., Gudmundsson G., Blöndal H., Arnason A., Thorsteinsson L. Immunohistochemical characterization of the amyloid deposits and quantitation of pertinent cerebrospinal fluid proteins in hereditary cerebral hemorrhage with amyloidosis. Stroke. 1987 Mar-Apr;18(2):431–440. doi: 10.1161/01.str.18.2.431. [DOI] [PubMed] [Google Scholar]
  10. Mandybur T. I. Cerebral amyloid angiopathy: possible relationship to rheumatoid vasculitis. Neurology. 1979 Oct;29(10):1336–1340. doi: 10.1212/wnl.29.10.1336. [DOI] [PubMed] [Google Scholar]
  11. Mandybur T. I., Gore I. Amyloid in late postirradiation necrosis of brain. Neurology. 1969 Oct;19(10):983–992. doi: 10.1212/wnl.19.10.983. [DOI] [PubMed] [Google Scholar]
  12. Masters C. L., Multhaup G., Simms G., Pottgiesser J., Martins R. N., Beyreuther K. Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J. 1985 Nov;4(11):2757–2763. doi: 10.1002/j.1460-2075.1985.tb04000.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Masters C. L., Simms G., Weinman N. A., Multhaup G., McDonald B. L., Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A. 1985 Jun;82(12):4245–4249. doi: 10.1073/pnas.82.12.4245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Murphy M. N., Sima A. A. Cerebral amyloid angiopathy associated with giant cell arteritis: a case report. Stroke. 1985 May-Jun;16(3):514–517. doi: 10.1161/01.str.16.3.514. [DOI] [PubMed] [Google Scholar]
  15. Nadeau S. E., Bebin J., Smith E. Nonspecific dementia, cortical blindness, and Congophilic angiopathy. A clinicopathological report. J Neurol. 1987 Jan;234(1):14–18. doi: 10.1007/BF00314002. [DOI] [PubMed] [Google Scholar]
  16. Probst A., Ulrich J. Amyloid angiopathy combined with granulomatous angiitis of the central nervous system: report on two patients. Clin Neuropathol. 1985 Nov-Dec;4(6):250–259. [PubMed] [Google Scholar]
  17. Schelper R. L., Adrian E. K., Jr Monocytes become macrophages; they do not become microglia: a light and electron microscopic autoradiographic study using 125-iododeoxyuridine. J Neuropathol Exp Neurol. 1986 Jan;45(1):1–19. doi: 10.1097/00005072-198601000-00001. [DOI] [PubMed] [Google Scholar]
  18. Selkoe D. J., Abraham C. R., Podlisny M. B., Duffy L. K. Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J Neurochem. 1986 Jun;46(6):1820–1834. doi: 10.1111/j.1471-4159.1986.tb08501.x. [DOI] [PubMed] [Google Scholar]
  19. Selkoe D. J., Bell D. S., Podlisny M. B., Price D. L., Cork L. C. Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science. 1987 Feb 20;235(4791):873–877. doi: 10.1126/science.3544219. [DOI] [PubMed] [Google Scholar]
  20. Shirahama T., Skinner M., Westermark P., Rubinow A., Cohen A. S., Brun A., Kemper T. L. Senile cerebral amyloid. Prealbumin as a common constituent in the neuritic plaque, in the neurofibrillary tangle, and in the microangiopathic lesion. Am J Pathol. 1982 Apr;107(1):41–50. [PMC free article] [PubMed] [Google Scholar]
  21. Tanzi R. E., Gusella J. F., Watkins P. C., Bruns G. A., St George-Hyslop P., Van Keuren M. L., Patterson D., Pagan S., Kurnit D. M., Neve R. L. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science. 1987 Feb 20;235(4791):880–884. doi: 10.1126/science.2949367. [DOI] [PubMed] [Google Scholar]
  22. Tanzi R. E., St George-Hyslop P. H., Haines J. L., Polinsky R. J., Nee L., Foncin J. F., Neve R. L., McClatchey A. I., Conneally P. M., Gusella J. F. The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene. Nature. 1987 Sep 10;329(6135):156–157. doi: 10.1038/329156a0. [DOI] [PubMed] [Google Scholar]
  23. Torack R. M., Lynch R. G. Cytochemistry of brain amyloid in adult dementia. Acta Neuropathol. 1981;53(3):189–196. doi: 10.1007/BF00688021. [DOI] [PubMed] [Google Scholar]
  24. Van Broeckhoven C., Genthe A. M., Vandenberghe A., Horsthemke B., Backhovens H., Raeymaekers P., Van Hul W., Wehnert A., Gheuens J., Cras P. Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families. Nature. 1987 Sep 10;329(6135):153–155. doi: 10.1038/329153a0. [DOI] [PubMed] [Google Scholar]
  25. Vinters H. V. Cerebral amyloid angiopathy. A critical review. Stroke. 1987 Mar-Apr;18(2):311–324. doi: 10.1161/01.str.18.2.311. [DOI] [PubMed] [Google Scholar]
  26. Wong C. W., Quaranta V., Glenner G. G. Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8729–8732. doi: 10.1073/pnas.82.24.8729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Wright J. R., Calkins E., Breen W. J., Stolte G., Schultz R. T. Relationship of amyloid to aging. Review of the literature and systematic study of 83 patients derived rom a general hospital population. Medicine (Baltimore) 1969 Jan;48(1):39–60. [PubMed] [Google Scholar]
  28. van Rijswijk M. H., van Heusden C. W. The potassium permanganate method. A reliable method for differentiating amyloid AA from other forms of amyloid in routine laboratory practice. Am J Pathol. 1979 Oct;97(1):43–58. [PMC free article] [PubMed] [Google Scholar]

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