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. 1985 Jun;119(3):448–455.

Autoimmune vasculitis resulting from in vitro immunization of lymphocytes to smooth muscle.

M N Hart, S K Tassell, K L Sadewasser, R L Schelper, S A Moore
PMCID: PMC1888015  PMID: 4014434

Abstract

Lymphocytes sensitized in vitro to syngenic microvascular smooth muscle and transferred to syngeneic recipients produced in vivo microvessel vasculitis characterized by mononuclear cells which adhered to endothelium, infiltrated the vessel wall, and formed a perivascular cuff. A granulomatous type of vascular inflammation was seen in 20% of the affected recipients in which the vessel smooth muscle appeared to be preferentially attacked. These lesions bear a striking resemblance to certain human vasculitides, and the model provides an important means of studying vasculitis as well as general cellular autoimmune disease mechanisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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