Abstract
In a study of the morphologic effects of various steroid hormones on human uterine endometrium and endometriotic tissue, specimens from 6 women were transplanted subcutaneously into 24 nude mice. In each case, specimens collected simultaneously were transplanted to 4 mice, endometrium to one lateral abdominal wall and endometriotic tissue to the other. All mice were given polyestradiol phosphate subcutaneously the first day after operation. After a 2-week interval, of each 4 mice, 1 mouse was given polyestradiol phosphate, 1 medroxyprogesterone acetate, 1 danazol, and 1 no further injections. This treatment continued for 8 weeks, after which the mice were killed and the grafts extirpated. Histologic changes in the grafts varied according to the treatment schedule but were very similar in both types of tissue. Our findings suggest that histologic differences between endometrium and endometriotic tissue seen under natural conditions may, at least partly, be due to variations in environmental factors.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bergqvist A., Jeppsson S., Kullander S., Ljungberg O. Human endometrium transplanted into nude mice. Histologic effects of various steroid hormones. Am J Pathol. 1985 May;119(2):336–344. [PMC free article] [PubMed] [Google Scholar]
- Dizerega G. S., Barber D. L., Hodgen G. D. Endometriosis: role of ovarian steroids in initiation, maintenance, and suppression. Fertil Steril. 1980 Jun;33(6):649–653. doi: 10.1016/s0015-0282(16)44780-1. [DOI] [PubMed] [Google Scholar]
- Giovanella B. C., Stehlin J. S., Jr, Williams L. J., Jr, Lee S. S., Shepard R. C. Heterotransplantation of human cancers into nude mice: a model system for human cancer chemotherapy. Cancer. 1978 Nov;42(5):2269–2281. doi: 10.1002/1097-0142(197811)42:5<2269::aid-cncr2820420527>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
- Jones R. C. The effect of a luteinizing hormone releasing hormone (LRH) agonist (Wy-40,972), levonorgestrel, danazol and ovariectomy on experimental endometriosis in the rat. Acta Endocrinol (Copenh) 1984 Jun;106(2):282–288. doi: 10.1530/acta.0.1060282. [DOI] [PubMed] [Google Scholar]
- Merenda C., Sordat B., Mach J. P., Carrel S. Human endometrial carcinomas serially transplanted in nude mice and established in continuous cell lines. Int J Cancer. 1975 Oct 15;16(4):559–570. doi: 10.1002/ijc.2910160406. [DOI] [PubMed] [Google Scholar]
- Pantelouris E. M., Hair J. Thymus dysgenesis in nude (nu nu) mice. J Embryol Exp Morphol. 1970 Nov;24(3):615–623. [PubMed] [Google Scholar]
- Povlsen C. O. Heterotransplants of human tumors in nude mice. Antibiot Chemother (1971) 1980;28:15–20. doi: 10.1159/000386054. [DOI] [PubMed] [Google Scholar]
- SCOTT R. B., WHARTON L. R., Jr The effect of estrone and progesterone on the growth of experimental endometriosis in rhesus monkeys. Am J Obstet Gynecol. 1957 Oct;74(4):852–865. doi: 10.1016/0002-9378(57)90061-3. [DOI] [PubMed] [Google Scholar]
- Shimosato Y., Kameya T., Nagai K., Hirohashi S., Koide T., Hayashi H., Nomura T. Transplantation of human tumors in nude mice. J Natl Cancer Inst. 1976 Jun;56(6):1251–1260. doi: 10.1093/jnci/56.6.1251. [DOI] [PubMed] [Google Scholar]
- Sussdorf D. H., McCann R. L. Serum concentrations of four immunoglobulins in non-immunized and immunized athymic ('nude') mice. Immunochemistry. 1975 Jul;12(6-7):607–609. doi: 10.1016/0019-2791(75)90094-4. [DOI] [PubMed] [Google Scholar]
- TE LINDE R. W., SCOTT R. B. Experimental endometriosis. Am J Obstet Gynecol. 1950 Nov;60(5):1147–1173. doi: 10.1016/0002-9378(50)90517-5. [DOI] [PubMed] [Google Scholar]
- Van Steenbrugge G. J., Blankenstein M. A., Bolt-de Vries J., Romijn J. C., Schröder F. H., Vihko P. Effect of hormone treatment on prostatic acid phosphatase in a serially transplantable human prostatic adenocarcinoma (PC-82). J Urol. 1983 Mar;129(3):630–633. doi: 10.1016/s0022-5347(17)52267-3. [DOI] [PubMed] [Google Scholar]
- Wortis H. H. Immunological responses of 'nude' mice. Clin Exp Immunol. 1971 Feb;8(2):305–317. [PMC free article] [PubMed] [Google Scholar]
- Zamah N. M., Dodson M. G., Stephens L. C., Buttram V. C., Jr, Besch P. K., Kaufman R. H. Transplantation of normal and ectopic human endometrial tissue into athymic nude mice. Am J Obstet Gynecol. 1984 Jul 15;149(6):591–597. doi: 10.1016/0002-9378(84)90240-0. [DOI] [PubMed] [Google Scholar]