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. 1986 Aug;124(2):253–262.

Distinct histologic patterns of acute, prolonged, and chronic rejection in vascularized rat pancreas allografts.

B Steiniger, J Klempnauer
PMCID: PMC1888289  PMID: 3526910

Abstract

In a model of pancreas whole organ transplantation in streptozotocin diabetic rats distinct histologic patterns of acute, prolonged and chronic rejection were defined by light microscopy. Allotransplantation between major histocompatibility complex (MHC) congenic and recombinant rat strains allowed an immunogenetic analysis of the effect of defined histocompatibility antigens on graft morphology. The impact of surgical techniques with preserved and suppressed exocrine secretion on graft histology was sequentially assessed in pancreas isograft recipients. MHC incompatibility was associated with acute rejection, non-MHC disparity with prolonged rejection and RT1.C mismatch with chronic rejection.

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Selected References

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  1. Edström C., Falkmer S. Pancreatic morphology and blood glucose level in rats at various intervals after duct ligation. Virchows Arch A Pathol Pathol Anat. 1968;345(2):139–153. doi: 10.1007/BF00548648. [DOI] [PubMed] [Google Scholar]
  2. Gooszen H. G., Bosman F. T., van Schilfgaarde R. The effect of duct obliteration on the histology and endocrine function of the canine pancreas. Transplantation. 1984 Jul;38(1):13–17. doi: 10.1097/00007890-198407000-00003. [DOI] [PubMed] [Google Scholar]
  3. Lindsey N. J., Nolan M. S., Slater D. N., Savas C. P., Boyle P. F., Herold A., Beck S., Fox M. Rat pancreas allotransplantation: a short term comparison of rejection patterns with different methods of exocrine drainage. J Pathol. 1983 Mar;139(3):259–274. doi: 10.1002/path.1711390304. [DOI] [PubMed] [Google Scholar]
  4. Orloff M. J., Lee S., Charters A. C., 3rd, Grambort D. E., Storck L. G., Knox D. Long term studies of pancreas transplantation in experimental diabetes mellitus. Ann Surg. 1975 Sep;182(3):198–206. doi: 10.1097/00000658-197509000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Pound A. W., Walker N. I. Involution of the pancreas after ligation of the pancreatic ducts. I: a histological study. Br J Exp Pathol. 1981 Dec;62(6):547–558. [PMC free article] [PubMed] [Google Scholar]
  6. Rausis C., Choudhury A., Ogata Y. Influence of pancreatic duct anastomosis on function of autotransplanted canine pancreatic segments. J Surg Res. 1970 Nov;10(11):551–557. doi: 10.1016/0022-4804(70)90081-8. [DOI] [PubMed] [Google Scholar]
  7. Shah K. H., Bitter-Suermann H., Save-Soderbergh J. Morphological findings in duct-ligated pancreas grafts in the rat. An analysis of isografts, allografts, and long-standing allografts in hosts conditioned by previous spleen allograft. Transplantation. 1980 Aug;30(2):83–89. [PubMed] [Google Scholar]
  8. Steiniger B., Klempnauer J., Wonigeit K. Altered distribution of class I and class II MHC antigens during acute pancreas allograft rejection in the rat. Transplantation. 1985 Sep;40(3):234–239. doi: 10.1097/00007890-198509000-00002. [DOI] [PubMed] [Google Scholar]
  9. Steiniger B., Klempnauer J., Wonigeit K. Phenotype and histological distribution of interstitial dendritic cells in the rat pancreas, liver, heart, and kidney. Transplantation. 1984 Aug;38(2):169–174. doi: 10.1097/00007890-198408000-00016. [DOI] [PubMed] [Google Scholar]
  10. Turner R. C., Mathews D. R., Holman R. R., Peto J. Relative contributions of insulin deficiency and insulin resistance in maturity-onset diabetes. Lancet. 1982 Mar 13;1(8272):596–598. doi: 10.1016/s0140-6736(82)91753-6. [DOI] [PubMed] [Google Scholar]
  11. Walker N. I., Pound A. W. An autoradiographic study of the cell proliferation during involution of the rat pancreas. J Pathol. 1983 Apr;139(4):407–418. doi: 10.1002/path.1711390402. [DOI] [PubMed] [Google Scholar]
  12. White E., Hildemann W. H., Mullen Y. Chronic kidney allograft reactions in rats. Transplantation. 1969 Nov;8(5):602–617. doi: 10.1097/00007890-196911000-00007. [DOI] [PubMed] [Google Scholar]

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