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. 1995 Dec;69(12):8076–8078. doi: 10.1128/jvi.69.12.8076-8078.1995

The leader peptide of Theiler's murine encephalomyelitis virus is a zinc-binding protein.

H H Chen 1, W P Kong 1, R P Roos 1
PMCID: PMC189757  PMID: 7494325

Abstract

The leader (L) peptide is located in the amino-terminal part of the polyprotein of members of the Cardiovirus (which includes Theiler's murine encephalomyelitis virus) and Aphthovirus genera of picornaviruses. Although the function of L is unknown, strain DA of Theiler's murine encephalomyelitis virus with a mutation of L produces a cell-specific restricted infection. We now report that the DA L peptide is a metalloprotein and that zinc binds to a Cys-His motif that is conserved among cardioviruses.

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Selected References

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