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Journal of Virology logoLink to Journal of Virology
. 1996 Jan;70(1):217–222. doi: 10.1128/jvi.70.1.217-222.1996

Foamy virus vectors.

D W Russell 1, A D Miller 1
PMCID: PMC189807  PMID: 8523528

Abstract

Human foamy virus (HFV) is a retrovirus of the spumavirus family. We have constructed vectors based on HFV that encode neomycin phosphotransferase and alkaline phosphatase. These vectors are able to transduce a wide variety of vertebrate cells by integration of the vector genome. Unlike vectors based on murine leukemia virus, HFV vectors are not inactivated by human serum, and they transduce stationary-phase cultures more efficiently than murine leukemia virus vectors. These properties, as well as their large packaging capacity, make HFV vectors promising gene transfer vehicles.

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Selected References

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