Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1987 Aug;128(2):217–224.

Immunohistochemical study of basement membrane antigens in bronchioloalveolar carcinoma.

W F Grigioni, G Biagini, S Garbisa, A D'Errico, M Milani, M Mastrorilli, V Vasi, V Villanacci, G Gozzetti, A M Mancini
PMCID: PMC1899618  PMID: 3039848

Abstract

Bronchioloalveolar carcinoma (BAC), not yet completely defined as a biologic entity, has recently been classified into two different types. Immunohistochemical investigations, aimed at characterizing basement membrane (BM) behavior in the two types of BAC, revealed different distribution patterns. The first (Type I BAC) showed a linear staining for laminin and Type IV collagen similar to normal lung. Fibronectin was widely present in the septal interstitium and patchily distributed along the BM. The second (Type II BAC) showed a variable reaction for Type IV collagen and fibronectin, whereas laminin was absent or appeared as short, interrupted tracts around the epithelial neoplastic population, similar to conventional adenocarcinoma of the lung. These results suggest that only Type I BAC shows structural characteristics different from those of conventional adenocarcinoma of the lung.

Full text

PDF
219

Images in this article

219Figure 1 and 2
on p.219
220Figure 3
on p.220
220Figure 4
on p.220
221Figure 5
on p.221
222Figure 6 and 7
on p.222
223Figure 8
on p.223

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bedrossian C. W., Weilbaecher D. G., Bentinck D. C., Greenberg S. D. Ultrastructure of human bronchiolo-alveolar cell carcinoma. Cancer. 1975 Oct;36(4):1399–1413. doi: 10.1002/1097-0142(197510)36:4<1399::aid-cncr2820360432>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  2. Bennett D. E., Sasser W. F. Bronchiolar carcinoma: a valid clinicopathologic entity? A study of 30 cases. Cancer. 1969 Nov;24(5):876–887. doi: 10.1002/1097-0142(196911)24:5<876::aid-cncr2820240504>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  3. Bonikos D. S., Hendrickson M., Bensch K. G. Pulmonary alveolar cell carcinoma. Fine structural and in vitro study of a case and critical review of this entity. Am J Surg Pathol. 1977 Jun;1(2):93–108. [PubMed] [Google Scholar]
  4. D'Errico A., Biagini G., Garbisa S., Milani M., Rizzoli R., Vasi V., Villanacci V., Grigioni W. F., Mancini A. M. Detection of extracellular matrix antigens (fibronectin, laminin, type IV in collagen) in paraffin embedded sections by avidin-biotin-peroxidase complex labelling. Basic Appl Histochem. 1986;30(3):325–332. [PubMed] [Google Scholar]
  5. Dunn D., Hertel B., Norwood W., Nicoloff D. M. Bronchioloalveolar cell carcinoma of the lung: a clinicopathological study. Ann Thorac Surg. 1978 Sep;26(3):241–249. doi: 10.1016/s0003-4975(10)63677-6. [DOI] [PubMed] [Google Scholar]
  6. Edgerton F., Rao U., Takita H., Vincent R. G. Bronchio-alveolar carcinoma. A clinical overview and bibliography. Oncology. 1981;38(5):269–273. doi: 10.1159/000225568. [DOI] [PubMed] [Google Scholar]
  7. Forster S. J., Talbot I. C., Critchley D. R. Laminin and fibronectin in rectal adenocarcinoma: relationship to tumour grade, stage and metastasis. Br J Cancer. 1984 Jul;50(1):51–61. doi: 10.1038/bjc.1984.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Geller S. A., Toker C. Pulmonary adenomatosis and peripheral adenocarcinoma of the lung. An ultrastructural demonstration of common morphologic features. Arch Pathol. 1969 Aug;88(2):148–154. [PubMed] [Google Scholar]
  9. Gospodarowicz D., Greenburg G., Birdwell C. R. Determination of cellular shape by the extracellular matrix and its correlation with the control of cellular growth. Cancer Res. 1978 Nov;38(11 Pt 2):4155–4171. [PubMed] [Google Scholar]
  10. Greenberg S. D., Smith M. N., Spjut H. J. Bronchiolo-alveolar carcinoma-cell of origin. Am J Clin Pathol. 1975 Feb;63(2):153–167. doi: 10.1093/ajcp/63.2.153. [DOI] [PubMed] [Google Scholar]
  11. Grigioni W. F., Biagini G., Errico A. D., Milani M., Villanacci V., Garbisa S., Mattioli S., Gozzetti G., Mancini A. M. Behaviour of basement membrane antigens in gastric and colorectal cancer. Immunohistochemical study. Acta Pathol Jpn. 1986 Feb;36(2):173–184. doi: 10.1111/j.1440-1827.1986.tb01471.x. [DOI] [PubMed] [Google Scholar]
  12. Hsu S. M., Raine L., Fanger H. The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. Am J Clin Pathol. 1981 Jun;75(6):816–821. doi: 10.1093/ajcp/75.6.816. [DOI] [PubMed] [Google Scholar]
  13. Hsu S. M., Raine L., Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981 Apr;29(4):577–580. doi: 10.1177/29.4.6166661. [DOI] [PubMed] [Google Scholar]
  14. Jacques J., Currie W. Bronchiolo-alveolar carcinoma: a Clara cell tumor? Cancer. 1977 Nov;40(5):2171–2180. doi: 10.1002/1097-0142(197711)40:5<2171::aid-cncr2820400527>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  15. Kimula Y. A histochemical and ultrastructural study of adenocarcinoma of the lung. Am J Surg Pathol. 1978 Sep;2(3):253–264. doi: 10.1097/00000478-197809000-00002. [DOI] [PubMed] [Google Scholar]
  16. Kuhn C. Fine structure of bronchiolo-alveolar cell carcinoma. Cancer. 1972 Oct;30(4):1107–1118. doi: 10.1002/1097-0142(197210)30:4<1107::aid-cncr2820300432>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  17. LIEBOW A. A. Bronchiolo-alveolar carcinoma. Adv Intern Med. 1960;10:329–358. [PubMed] [Google Scholar]
  18. Liotta L. A., Rao C. N., Barsky S. H. Tumor invasion and the extracellular matrix. Lab Invest. 1983 Dec;49(6):636–649. [PubMed] [Google Scholar]
  19. Manning J. T., Jr, Spjut H. J., Tschen J. A. Bronchioloalveolar carcinoma: The significance of two histopathologic types. Cancer. 1984 Aug 1;54(3):525–534. doi: 10.1002/1097-0142(19840801)54:3<525::aid-cncr2820540324>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  20. Martinez-Hernandez A., Amenta P. S. The basement membrane in pathology. Lab Invest. 1983 Jun;48(6):656–677. [PubMed] [Google Scholar]
  21. Marzano M. J., Deschler T., Mintzer R. A. Alveolar cell carcinoma. Chest. 1984 Jul;86(1):123–128. doi: 10.1378/chest.86.1.123. [DOI] [PubMed] [Google Scholar]
  22. McCarthy J. B., Furcht L. T. Laminin and fibronectin promote the haptotactic migration of B16 mouse melanoma cells in vitro. J Cell Biol. 1984 Apr;98(4):1474–1480. doi: 10.1083/jcb.98.4.1474. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Miller W. T., Husted J., Freiman D., Atkinson B., Pietra G. G. Bronchioloalveolar carcinoma: two clinical entities with one pathologic diagnosis. AJR Am J Roentgenol. 1978 May;130(5):905–912. doi: 10.2214/ajr.130.5.905. [DOI] [PubMed] [Google Scholar]
  24. Nash G., Langlinais P. C., Greenawald K. A. Alveolar cell carcinoma: does it exist? Cancer. 1972 Feb;29(2):322–326. doi: 10.1002/1097-0142(197202)29:2<322::aid-cncr2820290209>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  25. Rosenblatt M. B., Lisa J. R., Collier F. Primary and metastatic bronciolo-alveolar carcinoma. Dis Chest. 1967 Aug;52(2):147–152. doi: 10.1378/chest.52.2.147. [DOI] [PubMed] [Google Scholar]
  26. Singh G., Katyal S. L., Ordonez N. G., Dail D. H., Negishi Y., Weedn V. W., Marcus P. B., Weldon-Linne C. M., Axiotis C. A., Alvarez-Fernandez E. Type II pneumocytes in pulmonary tumors. Implications for histogenesis. Arch Pathol Lab Med. 1984 Jan;108(1):44–48. [PubMed] [Google Scholar]
  27. Tao L. C., Delarue N. C., Sanders D., Weisbrod G. Bronchiolo-alveolar carcinoma: a correlative clinical and cytologic study. Cancer. 1978 Dec;42(6):2759–2767. doi: 10.1002/1097-0142(197812)42:6<2759::aid-cncr2820420635>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  28. Zolliker A. S., Jacques J. Clara cell carcinoma of the lung. Hum Pathol. 1981 Aug;12(8):748–750. doi: 10.1016/s0046-8177(81)80177-3. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES