Abstract
In this study, 30-day-old male Sprague-Dawley rats, were inoculated intraperitoneally with a single dose of 45, 90, and 180 mg/kg of N-ethyl-N-Nitrosourea (ENU). A wide spectrum of neoplasms occurred. The most common tumors were those of the mammary gland and of the nervous system. Although the incidence of mammary tumors was highest in the two high-dose groups (90 and 180 mg/kg ENU), the incidence of neurogenic tumors was highest in the 45 mg/kg dose group. Mammary tumor development led to early death and precluded development of tumors of the nervous system, which require a longer latency period. A variety of neoplasms of other organs have been associated particularly with high doses of ENU, including ameloblastic tumors, carcinomas of the thyroid, prostate, kidney, pancreas, intestine, and lung, hemilymphatic tumors, and sarcomas. It is concluded that large doses of ENU are capable of expanding the tumor spectrum in young male rats beyond the target organs generally affected with lower doses, as described in earlier reports.
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- Druckrey H., Ivanković S., Preussmann R. Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant rats. Nature. 1966 Jun 25;210(5043):1378–1379. doi: 10.1038/2101378a0. [DOI] [PubMed] [Google Scholar]
- Gart J. J., Chu K. C., Tarone R. E. Statistical issues in interpretation of chronic bioassay tests for carcinogenicity. J Natl Cancer Inst. 1979 Apr;62(4):957–974. [PubMed] [Google Scholar]
- Greiner J. W., Bryan A. H., Malan-Shibley L. B., Janss D. H. Aryl hydrocarbon hydroxylase and epoxide hydratase activities: age effects in mammary epithelial cells of Sprague-Dawley rats. J Natl Cancer Inst. 1980 May;64(5):1127–1133. [PubMed] [Google Scholar]
- Koestner A., Swenberg J. A., Wechsler W. Transplacental production with ethylnitrosourea of neoplasms of the nervous system in Sprague-Dawley rats. Am J Pathol. 1971 Apr;63(1):37–56. [PMC free article] [PubMed] [Google Scholar]
- Langham R. F., Mostosky U. V., Schirmer R. G. Ameloblastic odontoma in the dog. Am J Vet Res. 1969 Oct;30(10):1873–1876. [PubMed] [Google Scholar]
- Nagasawa H. Causes of age-dependency of mammary tumour induction by carcinogens in rats. Biomedicine. 1981 Feb;34(1):9–11. [PubMed] [Google Scholar]
- Russo J., Wilgus G., Tait L., Russo I. H. Influence of age and parity on the susceptibility of rat mammary gland epithelial cells in primary cultures to 7,12-dimethylbenz(a)anthracene. In Vitro. 1981 Oct;17(10):877–884. doi: 10.1007/BF02618283. [DOI] [PubMed] [Google Scholar]
- Slavin G., Cameron H. M. Ameloblastomas in Africans from Tanzania and Uganda. A report of 56 cases. Br J Cancer. 1969 Mar;23(1):31–38. doi: 10.1038/bjc.1969.5. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stoica G., Koestner A., Capen C. C. Characterization of N-ethyl-N-nitrosourea--induced mammary tumors in the rat. Am J Pathol. 1983 Feb;110(2):161–169. [PMC free article] [PubMed] [Google Scholar]
- Su C. M., Brash D. E., Chang M. J., Hart R. W., D'Ambrosio S. M. Induction of single-strand breaks plus alkali-labile bonds by N-nitrosoureas in rat tissues in vivo: ethylnitrosourea versus benzylnitrosourea. Mutat Res. 1983 Mar;108(1-3):1–12. doi: 10.1016/0027-5107(83)90105-7. [DOI] [PubMed] [Google Scholar]