Schwann cell remyelination and recurrent demyelination in the central nervous system of mice infected with attenuated Theiler's virus.

Abstract

Theiler's murine encephalomyelitis virus (TMEV) infection produces a chronic demyelinating disease in mice, and myelin breakdown appears to be immune-mediated. By using an attenuated TMEC strain, WW virus, to infect mice, the course of the disease was slowed and the severity of the inflammatory and glial responses were reduced. In this circumstance, most of the demyelinating lesions showed extensive remyelination, predominantly by Schwann cells. In addition, it was demonstrated that there was recurrent demyelinating activity in the central nervous system (CNS) of infected animals. It is suggested that the rapidity and intensity of demyelinating lesions may influence the potential for remyelination and that Schwann cell participation may be a more important mechanism of myelin repair than it is now thought to be. The fact that there is a recurrent demyelination in TMEV infection increases its relevance as an experimental animal model for multiple sclerosis.

Full text

PDF

• Previous
• 101
• …
• 115
• 116
• 117
• …
• 122
• Next

Images in this article

Figure 11
on p.116

Figure 12
on p.117

Figure 13
on p.117

Figure 14
on p.119

Figure 15
on p.119

Figure 1
on p.111

Figure 2
on p.111

Figure 3
on p.112

Figure 4
on p.112

Figure 16
on p.121

Figure 17
on p.121

Figure 5
on p.113

Figure 6
on p.113

Figure 18
on p.122

Figure 7
on p.114

Figure 8
on p.114

Figure 9
on p.115

Figure 10
on p.115