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. 1973 Feb;70(2):175–198.

Renewal of Alveolar Epithelium in the Rat Following Exposure to NO2

Michael J Evans, Linda J Cabral, Robert J Stephens, Gustave Freeman
PMCID: PMC1903972  PMID: 4566990

Abstract

This research was undertaken to study the kinetics of Type 2 cell division and the fate of the Type 2 sister cell following exposure to NO2. To accomplish this, male rats were exposed to NO2. Dividing cells were labeled with 3H-TdR and studied with autoradiographic technics in the light and electron microscopes for up to 72 hours after labeling. The kinetics of cell division were determined from a curve constructed from the percent of labeled mitotic figures. The fate of the Type 2 sister cells was determined by studying tissues at 24, 48 and 72 hours after labeling with 3H-TdR. The results show that Type 2 cells may divide and the sister cells transform into Type 1 cells. These data support an interpretation of the mechanism for cell renewal of the alveolar epithelium in which Type 2 cells are the progenitor cells for Type 1 cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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