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. 1973 Sep;72(3):521–540.

Studies on Cellular Autophagocytosis

Cyclic AMP- and Dibutyryl Cyclic AMP-Stimulated Autophagy in Rat Liver

J D Shelburne, A U Arstila, B F Trump
PMCID: PMC1904032  PMID: 4125701

Abstract

Intraperitoneal injections of either cyclic AMP or dibutyryl cyclic AMP are capable of producing a wave of autophagy in rat liver which resembles closely that stimulated by glucagon. These autophagic vacuoles are acid-phosphatase-positive and appear to arise via the envelopment of organelles by double-walled cisterna. At later times these autophagic vacuoles are usually surrounded by a single membrane. Injection of equimolar amounts of 5′-AMP failed to produce a wave of autophagy. These findings constitute preliminary evidence that glucagon-stimulated autophagy is mediated at least in part by cyclic AMP.

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These references are in PubMed. This may not be the complete list of references from this article.

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