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. 1973 Nov;73(2):457–476.

The Development of the Pathologic Changes of Alzheimer's Disease and Senile Dementia in Patients with Down's Syndrome

Peter C Burger, F Stephen Vogel
PMCID: PMC1904076  PMID: 4271339

Abstract

Senile plaques, neurofibrillary change and granulovacuolar degeneration characterize Alzheimer's disease (presenile dementia) and senile dementia and are also seen in the aged human brain. The development of these lesions was studied in 13 patients with Down's syndrome, ages 12 to 65, with the purpose of defining similarities and dissimilarities, if any, between their morphologies in these four conditions. Evaluation by light and, when applied, electron microscopy established apparent identities. The findings suggest that Down's syndrome, with its partially characterized genotypic and phenotypic abnormalities, is an appropriate model for the study of the pathogenesis of these lesions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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