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. 1973 Dec;73(3):727–734.

Lysosomes in Aortic Smooth Muscle Cells

Effects of Hypertension

Harvey Wolinsky, Sidney Goldfischer, Bernice Schiller, Lisa E Kasak
PMCID: PMC1904092  PMID: 4767260

Abstract

Hypertension induces hypertrophy and increased turnover of aortic smooth muscle cells along with an accumulation of connective tissue in the aortic wall. We identified the lysosomes in normal and hypertensive aortic muscle cells by light and electron microscopy, utilizing cytochemical staining for acid phosphatase activity. Lysosomes were found to be more numerous in hypertensive vessels. Biochemical assays of two specific lysosomal enzymes revealed a doubling of acid phosphatase and a more than threefold increase in β-N-acetyl-glucosaminidase activities in hypertensive aortas.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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