Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1964 Feb;44(2):319–347.

An Electron Microscopic Study of the Homograft Reaction

Joseph Wiener, David Spiro, Paul S Russell
PMCID: PMC1906995  PMID: 14119173

Full text

PDF
321

Images in this article

333Fig. 1
on p.333
333Fig. 2
on p.333
335Fig. 3
on p.335
335Fig. 4
on p.335
337Fig. 5
on p.337
337Fig. 6
on p.337
339Fig. 7
on p.339
339Fig. 8
on p.339
340Fig. 9
on p.340
340Fig. 10
on p.340
341Fig. 11
on p.341
342Fig. 12
on p.342
343Fig. 13
on p.343
345Fig. 14
on p.345
347Fig. 15
on p.347
347Fig. 16
on p.347

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALGIRE G. H. Vascular reactions of normal and malignant tissues in vivo. VII. Observations on vascular reactions in destruction of tumor homografts. J Natl Cancer Inst. 1954 Dec;15(3):483–491. [PubMed] [Google Scholar]
  2. ALGIRE G. H., WEAVER J. M., PREHN R. T. Studies on tissue homotransplantation in mice, using diffusion-chamber methods. Ann N Y Acad Sci. 1957 Mar 22;64(5):1009–1013. doi: 10.1111/j.1749-6632.1957.tb52492.x. [DOI] [PubMed] [Google Scholar]
  3. AMOS D. B., DAY E. D. Passive immunity against four mouse leukoses by means of isoimmune sera. Ann N Y Acad Sci. 1957 Mar 22;64(5):851–858. doi: 10.1111/j.1749-6632.1957.tb52479.x. [DOI] [PubMed] [Google Scholar]
  4. AMOS D. B., GORER P. A., MIKULSKA B. M., BILLINGHAM R. E., SPARROW E. M. An antibody response to skin homografts in mice. Br J Exp Pathol. 1954 Apr;35(2):203–208. [PMC free article] [PubMed] [Google Scholar]
  5. ARNASON B. G., JANKOVIC B. D., WAKSMAN B. H., WENNERSTEN C. Role of the thymus in immune reactions in rats. II. Suppressive effect of thymectomy at birth on reactions of delayed (cellular) hypersensitivity and the circulating small lymphocyte. J Exp Med. 1962 Aug 1;116:177–186. doi: 10.1084/jem.116.2.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BERRIAN J. H., BRENT L. Cell-bound antibodies in transplantation immunity. Ann N Y Acad Sci. 1958 Oct 7;73(3):654–662. doi: 10.1111/j.1749-6632.1959.tb40841.x. [DOI] [PubMed] [Google Scholar]
  7. BESSIS M. C. Ultrastructure of lymphoid and plasma cells in realtion to globulin and antibody formation. Lab Invest. 1961 Nov-Dec;10:1040–1067. [PubMed] [Google Scholar]
  8. BILLINGHAM R. E., BRENT L., MEDAWAR P. B. Quantitative studies on tissue transplantation immunity. II. The origin, strength and duration of actively and adoptively acquired immunity. Proc R Soc Lond B Biol Sci. 1954 Dec 15;143(910):58–80. doi: 10.1098/rspb.1954.0054. [DOI] [PubMed] [Google Scholar]
  9. BILLINGHAM R. E., REYNOLDS J. Transplantation studies on sheets of pure epidermal epithelium and on epidermal cell suspensions. Br J Plast Surg. 1952 Apr;5(1):25–36. doi: 10.1016/s0007-1226(52)80004-9. [DOI] [PubMed] [Google Scholar]
  10. BILLINGHAM R. E., SILVERS W. K., WILSON D. B. Adoptive transfer of transplantation immunity by means of blood-borne cells. Lancet. 1962 Mar 10;1(7228):512–515. doi: 10.1016/s0140-6736(62)91484-8. [DOI] [PubMed] [Google Scholar]
  11. BINET J. L., MATHE G. Optical and electron microscope studies of 'immunologically competent cells' in graft reactions. Nature. 1962 Mar 10;193:992–993. doi: 10.1038/193992a0. [DOI] [PubMed] [Google Scholar]
  12. BRAUNSTEINER H., FELLINGER K., PAKESCH F. Demonstration of a cytoplasmic structure in plasma cells. Blood. 1953 Oct;8(10):916–922. [PubMed] [Google Scholar]
  13. BRENT L., BROWN J., MEDAWAR P. B. Skin transplantation immunity in relation to hypersensitivity. Lancet. 1958 Sep 13;2(7046):561–564. doi: 10.1016/s0140-6736(58)90202-2. [DOI] [PubMed] [Google Scholar]
  14. BRENT L. Tissue transplantation immunity. Prog Allergy. 1958;5:271–348. [PubMed] [Google Scholar]
  15. BRODY I. An ultrastructural study on the role of the keratohyalin granules in the keratinization process. J Ultrastruct Res. 1959 Oct;3:84–104. doi: 10.1016/s0022-5320(59)80018-6. [DOI] [PubMed] [Google Scholar]
  16. CAULFIELD J. B. Effects of varying the vehicle for OsO4 in tissue fixation. J Biophys Biochem Cytol. 1957 Sep 25;3(5):827–830. doi: 10.1083/jcb.3.5.827. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. CLARK W. H., Jr, HIBBS R. G. Electron microscope studies of the human epidermis: the clear cell of Masson (dendritic cell or melanocyte). J Biophys Biochem Cytol. 1958 Nov 25;4(6):679–684. doi: 10.1083/jcb.4.6.679. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. FAWCETT D. W. The membranes of the cytoplasm. Lab Invest. 1961 Nov-Dec;10:1162–1188. [PubMed] [Google Scholar]
  19. FELDMAN M., ELSON D., GLOBERSON A. Antibodies in ribonucleoproteins. Nature. 1960 Jan 30;185:317–319. doi: 10.1038/185317a0. [DOI] [PubMed] [Google Scholar]
  20. FLOREY H. W., GRANT L. H. Leucocyte migration from small blood vessels stimulated with ultraviolet light: an electron-microscope study. J Pathol Bacteriol. 1961 Jul;82:13–17. doi: 10.1002/path.1700820103. [DOI] [PubMed] [Google Scholar]
  21. GORER P. A. Some recent work on tumor immunity. Adv Cancer Res. 1956;4:149–186. doi: 10.1016/s0065-230x(08)60724-1. [DOI] [PubMed] [Google Scholar]
  22. GORER P. A. The antibody response to skin homografts in mice. Ann N Y Acad Sci. 1955 Jan 24;59(3):365–373. doi: 10.1111/j.1749-6632.1955.tb45948.x. [DOI] [PubMed] [Google Scholar]
  23. HIBBS R. G., CLARK W. H., Jr Electron microscope studies of the human epidermis; the cell boundaries and topography of the stratum malpighii. J Biophys Biochem Cytol. 1959 Aug;6(1):71–76. doi: 10.1083/jcb.6.1.71. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. HILL F. Fibre composition of tough and tender muscles of meat animals. Nature. 1962 Oct 6;196:65–66. doi: 10.1038/196065a0. [DOI] [PubMed] [Google Scholar]
  25. KANDUTSCH A. A., REINERT-WENCK U. Studies on a substance that promotes tumor homograft survival (the enhancing substance); its distribution and some properties. J Exp Med. 1957 Feb 1;105(2):125–139. doi: 10.1084/jem.105.2.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. LAWRENCE H. S. Homograft sensitivity. An expression of the immunologic origins and consequences of individuality. Physiol Rev. 1959 Oct;39:811–859. doi: 10.1152/physrev.1959.39.4.811. [DOI] [PubMed] [Google Scholar]
  27. MARTINEZ C., KERSEY J., PAPERMASTER B. W., GOOD R. A. Skin homograft survival in thymectomized mice. Proc Soc Exp Biol Med. 1962 Jan;109:193–196. doi: 10.3181/00379727-109-27149. [DOI] [PubMed] [Google Scholar]
  28. MILLER J. F. Immunological function of the thymus. Lancet. 1961 Sep 30;2(7205):748–749. doi: 10.1016/s0140-6736(61)90693-6. [DOI] [PubMed] [Google Scholar]
  29. MITCHISON N. A. Passive transfer of transplantation immunity. Proc R Soc Lond B Biol Sci. 1954 Feb 18;142(906):72–87. doi: 10.1098/rspb.1954.0007. [DOI] [PubMed] [Google Scholar]
  30. McBride R. A., Wheeler H. B., Smith L. L., Moore F. D., Dammin G. J. Homotransplantation of the Canine Liver as an Orthotopic Vascularized Graft: Histologic and Functional Correlations During Residence in the New Host. Am J Pathol. 1962 Nov;41(5):501–519. [PMC free article] [PubMed] [Google Scholar]
  31. Medawar P. B. The behaviour and fate of skin autografts and skin homografts in rabbits: A report to the War Wounds Committee of the Medical Research Council. J Anat. 1944 Oct;78(Pt 5):176–199. [PMC free article] [PubMed] [Google Scholar]
  32. NAJARIAN J. S., FELDMAN J. D. Passive transfer of transplantation immunity. I. Tritiated lymphoid cells. II. Lymphoid cells in millipore chambers. J Exp Med. 1962 May 1;115:1083–1093. doi: 10.1084/jem.115.5.1083. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. ODLAND G. F. The fine structure of the interrelationship of cells in the human epidermis. J Biophys Biochem Cytol. 1958 Sep 25;4(5):529–538. [PMC free article] [PubMed] [Google Scholar]
  34. ROGERS B. O., CONVERSE J. M., TAYLOR A. C., CAMPBELL R. M. Eosinophile in human skin homografting. Proc Soc Exp Biol Med. 1953 Mar;82(3):523–526. doi: 10.3181/00379727-82-20167. [DOI] [PubMed] [Google Scholar]
  35. SCOTHORNE R. J., MCGREGOR I. A. Cellular changes in lymph nodes and spleen following skin homografting in the rabbit. J Anat. 1955 Jul;89(3):283–292. [PMC free article] [PubMed] [Google Scholar]
  36. SCOTHORNE R. J., McGREGOR I. A. The vascularization of autografts and homografts of rabbit skin. J Anat. 1953 Oct;87(4):379–386. [PMC free article] [PubMed] [Google Scholar]
  37. SCOTHORNE R. J. Studies on the response of the regional lymph node to skin homografts. Ann N Y Acad Sci. 1957 Mar 22;64(5):1028-38; discussion, 1038-9. doi: 10.1111/j.1749-6632.1957.tb52494.x. [DOI] [PubMed] [Google Scholar]
  38. SCOTHORNE R. J., TOUGH J. S. Histochemical studies of human skin autografts and homografts. Br J Plast Surg. 1952 Oct;5(3):161–170. doi: 10.1016/s0007-1226(52)80016-5. [DOI] [PubMed] [Google Scholar]
  39. SELBY C. C. An electron microscope study of the epidermis of mammalian skin in thin sections. I. Dermo-epidermal junction and basal cell layer. J Biophys Biochem Cytol. 1955 Sep 25;1(5):429–444. doi: 10.1083/jcb.1.5.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. SNELL G. D. Incompatibility reactions to tumor homotransplants with particular reference to the role of the tumor; a review. Cancer Res. 1957 Jan;17(1):2–10. [PubMed] [Google Scholar]
  41. SNELL G. D. The homograft reaction. Annu Rev Microbiol. 1957;11:439–458. doi: 10.1146/annurev.mi.11.100157.002255. [DOI] [PubMed] [Google Scholar]
  42. STETSON C. A., Jr, DEMOPOULOS R. Reactions of skin homografts with specific immune sera. Ann N Y Acad Sci. 1958 Oct 7;73(3):687–692. doi: 10.1111/j.1749-6632.1959.tb40845.x. [DOI] [PubMed] [Google Scholar]
  43. TERASAKI P. I., BOLD E. J., CANNON J. A., LONGMIRE W. P., Jr Antibody response to homografts. VI. In vitro cytotoxins produced by skin homografts in rabbits. Proc Soc Exp Biol Med. 1961 Jan;106:133–136. doi: 10.3181/00379727-106-26261. [DOI] [PubMed] [Google Scholar]
  44. TOOLAN H. W. Studies of adult and embryonic skin homografts on conditioned or normal rabbits, with emphasis on the possible role of the ground substance. Ann N Y Acad Sci. 1958 Oct 7;73(3):546–560. doi: 10.1111/j.1749-6632.1959.tb40831.x. [DOI] [PubMed] [Google Scholar]
  45. VOISIN G. A., MAUER P. Studies on the role of antibodies in the failure of homografts. Ann N Y Acad Sci. 1957 Mar 22;64(5):1053-70; discussion, 1070-3. doi: 10.1111/j.1749-6632.1957.tb52496.x. [DOI] [PubMed] [Google Scholar]
  46. WAKSMAN B. H., ARNASON B. G., JANKOVIC B. D. Role of the thymus in immune reactions in rats. III. Changes in the lymphoid organs of thymectomized rats. J Exp Med. 1962 Aug 1;116:187–206. doi: 10.1084/jem.116.2.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. WIENER J., SPIRO D. Electron microscope studies in experimental thrombosis. Exp Mol Pathol. 1962 Dec;1:554–572. doi: 10.1016/0014-4800(62)90042-4. [DOI] [PubMed] [Google Scholar]
  48. WILLIAMSON J. R., GRISHAM J. W. Electron microscopy of leukocytic margination and emigration in acute inflammation in dog pancreas. Am J Pathol. 1961 Aug;39:239–256. [PMC free article] [PubMed] [Google Scholar]
  49. ZELICKSON A. S. Normal human keratinization processes as demonstrated by electron microscopy. J Invest Dermatol. 1961 Nov;37:369–379. [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES